In:
eLife, eLife Sciences Publications, Ltd, Vol. 5 ( 2016-02-02)
Abstract:
Small organs called lymph nodes are found throughout the body and help to filter out harmful particles and cells. Lymph nodes are packed with different types of immune cells, such as the T-cells that play a number of roles in detecting and destroying bacteria, viruses and other disease-causing microbes. Within the lymph node, T-cells crawl along a meshwork made up of cells called fibroblastic reticular cells. The T-cells appear to move in random patterns, but the signals that drive this movement remain ill-defined. Now, Takeda et al. reveal that a lipid called lysophosphatidic acid (LPA), which is produced by the fibroblastic reticular cells, is responsible for regulating how T-cells move around inside the lymph nodes. T-cells are able to detect LPA via certain receptor proteins on their surface. Takeda et al. engineered mice that were either unable to produce a particular LPA receptor on their T-cells, or that produced less LPA than normal. The T-cells of these mice moved around less than T-cells in normal mice. Further experiments revealed that LPA signaling also affects the signaling pathway that alters how well the T-cells stick to nearby surfaces. This suggests that LPA helps to optimize T-cell movement to allow the cells to navigate the small spaces found between the fibroblastic reticular cells. In the future, targeting the processes involved in LPA signaling could help to develop new treatments for disorders of the immune system.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.10561.001
DOI:
10.7554/eLife.10561.002
DOI:
10.7554/eLife.10561.003
DOI:
10.7554/eLife.10561.004
DOI:
10.7554/eLife.10561.005
DOI:
10.7554/eLife.10561.006
DOI:
10.7554/eLife.10561.007
DOI:
10.7554/eLife.10561.008
DOI:
10.7554/eLife.10561.009
DOI:
10.7554/eLife.10561.010
DOI:
10.7554/eLife.10561.011
DOI:
10.7554/eLife.10561.012
DOI:
10.7554/eLife.10561.013
DOI:
10.7554/eLife.10561.014
DOI:
10.7554/eLife.10561.015
DOI:
10.7554/eLife.10561.016
DOI:
10.7554/eLife.10561.017
DOI:
10.7554/eLife.10561.018
DOI:
10.7554/eLife.10561.019
DOI:
10.7554/eLife.10561.020
DOI:
10.7554/eLife.10561.021
DOI:
10.7554/eLife.10561.022
DOI:
10.7554/eLife.10561.023
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2016
detail.hit.zdb_id:
2687154-3
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