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  • 1
    Online Resource
    Online Resource
    Gonadotrope Plasticity at Cellular and Population Levels
    The Endocrine Society ; 2012
    In:  Endocrinology Vol. 153, No. 10 ( 2012-10-01), p. 4729-4739
    Details
    In: Endocrinology, The Endocrine Society, Vol. 153, No. 10 ( 2012-10-01), p. 4729-4739
    Abstract: Hormone-secreting cells within the anterior pituitary gland may form organized and interdigitated networks that adapt to changing endocrine conditions in different physiological contexts. For gonadotropes, this might reflect a strategy to cope with acute changes throughout different female reproductive stages. The current study examined gonadotropes in female mice at characteristically different hormonal stages: prepubertal, postpubertal, and lactating. Gonadotrope plasticity was examined at the level of the whole population and single cells at different stages by imaging both fixed and live pituitary slices. The use of a model animal providing for the identification of selectively fluorescent gonadotropes allowed the particular advantage of defining cellular plasticity specifically for gonadotropes. In vivo analyses of gonadotropes relative to vasculature showed significantly different gonadotrope distributions across physiological states. Video microscopy studies using live slices ex vivo demonstrated pituitary cell plasticity in the form of movements and protrusions in response to GnRH. As positive feedback from rising estradiol levels is important for priming the anterior pituitary gland for the LH surge, experiments provide evidence of estradiol effects on GnRH signaling in gonadotropes. The experiments presented herein provide new insight into potential plasticity of gonadotropes within the anterior pituitary glands of female mice.
    Type of Medium: Online Resource
    ISSN: 0013-7227 , 1945-7170
    URL: Article
    DOI: 10.1210/en.2012-1360
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2012
    detail.hit.zdb_id: 2011695-0
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  • 2
    Online Resource
    Online Resource
    Theta Oscillations Organize Spiking Activity in Higher-Order Visual Thalamus during Sustained Attention
    Society for Neuroscience ; 2018
    In:  eneuro Vol. 5, No. 1 ( 2018-01), p. ENEURO.0384-17.2018-
    Details
    In: eneuro, Society for Neuroscience, Vol. 5, No. 1 ( 2018-01), p. ENEURO.0384-17.2018-
    Abstract: Higher-order visual thalamus plays a fundamental but poorly understood role in attention-demanding tasks. To investigate how neuronal dynamics in higher-order visual thalamus are modulated by sustained attention, we performed multichannel electrophysiological recordings in the lateral posterior-pulvinar complex (LP/pulvinar) in the ferret ( Mustela putorius furo ). We recorded single unit activity and local field potential (LFP) during the performance of the five-choice serial reaction time task (5-CSRTT), which is used in both humans and animals as an assay of sustained attention. We found that half of the units exhibited an increasing firing rate during the delay period before stimulus onset (attention-modulated units). In contrast, the non-attention-modulated units responded to the stimulus, but not during the delay period. Spike-field coherence (SFC) of only the attention-modulated neurons significantly increased from the start of the delay period until screen touch, predominantly in the θ frequency band. In addition, θ power and θ/γ phase amplitude coupling (PAC) were elevated throughout the delay period. Our findings suggest that the θ oscillation plays a central role in orchestrating thalamic signaling during sustained attention.
    Type of Medium: Online Resource
    ISSN: 2373-2822
    URL: Article
    DOI: 10.1523/ENEURO.0384-17.2018
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2018
    detail.hit.zdb_id: 2800598-3
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  • 3
    Online Resource
    Online Resource
    Dynamic reconfiguration of cortical functional connectivity across brain states
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-08-18)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-08-18)
    Abstract: Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfigures across states. Here, we investigate state-dependent shifts in cortical functional connectivity by recording local field potentials (LFPs) during spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticographic (µECoG) arrays positioned over occipital, parietal, and temporal cortical regions. To objectively classify brain state, we describe a data-driven approach that projects time-varying LFP spectral properties into brain state space. Distinct brain states displayed markedly different patterns of cross-frequency phase-amplitude coupling and inter-electrode phase synchronization across several LFP frequency bands. The largest across-state differences in functional connectivity were observed between periods of presumed slow-wave and rapid-eye-movement-sleep/active-state, which were characterized by the contrasting phenomena of cortical network fragmentation and global synchronization, respectively. Collectively, our data provide strong evidence that large-scale functional interactions in the brain dynamically reconfigure across behavioral states.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-017-08050-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 4
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    Online Resource
    Early Development of Network Oscillations in the Ferret Visual Cortex
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-12-19)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-12-19)
    Abstract: Although oscillations during development have been characterized in a wide range of neural systems, little is known about the interaction between these network oscillations and neuronal spiking, and the interactions among different oscillation frequencies. Here we recorded the spontaneous and visual-elicited local field potential (LFP) and multi-unit activity (MUA) in the visual cortex of freely-moving juvenile ferrets before and after eye-opening. We found that both the spontaneous and visually-elicited LFP power was increased after eye-opening, especially in higher frequency bands ( 〉 30 Hz). Spike LFP phase coupling was decreased for lower frequency bands (theta and alpha) but slightly increased for higher frequencies (high-gamma band). A similar shift towards faster frequencies also occurred for phase-amplitude coupling; with maturation, the coupling of the theta/alpha/beta band amplitude to the delta phase was decreased and the high-gamma amplitude coupling to theta/alpha phase was increased. This shift towards higher frequencies was also reflected in the visual responses; the LFP oscillation became more entrained by visual stimulation with higher frequencies ( 〉 10 Hz). Taken together, these results suggest gamma oscillation as a signature of the maturation of cortical circuitry.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-017-17502-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 5
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    Online Resource
    Intrinsic coupling modes reveal the functional architecture of cortico-tectal networks
    American Association for the Advancement of Science (AAAS) ; 2015
    In:  Science Advances Vol. 1, No. 7 ( 2015-08-07)
    Details
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 1, No. 7 ( 2015-08-07)
    Abstract: In the absence of sensory stimulation or motor output, the brain exhibits complex spatiotemporal patterns of intrinsically generated neural activity. Analysis of ongoing brain dynamics has identified the prevailing modes of cortico-cortical interaction; however, little is known about how such patterns of intrinsically generated activity are correlated between cortical and subcortical brain areas. We investigate the correlation structure of ongoing cortical and superior colliculus (SC) activity across multiple spatial and temporal scales. Ongoing cortico-tectal interaction was characterized by correlated fluctuations in the amplitude of delta, spindle, low gamma, and high-frequency oscillations ( 〉 100 Hz). Of these identified coupling modes, topographical patterns of high-frequency coupling were the most consistent with patterns of anatomical connectivity, reflecting synchronized spiking within cortico-tectal networks. Cortico-tectal coupling at high frequencies was temporally parcellated by the phase of slow cortical oscillations and was strongest for SC-cortex channel pairs that displayed overlapping visual spatial receptive fields. Despite displaying a high degree of spatial specificity, cortico-tectal coupling in lower-frequency bands did not match patterns of cortex-to-SC anatomical connectivity. Collectively, our findings demonstrate that neural activity is spontaneously coupled between cortex and SC, with high- and low-frequency modes of coupling reflecting direct and indirect cortico-tectal interactions, respectively.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    URL: Article
    DOI: 10.1126/sciadv.1500229
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2015
    detail.hit.zdb_id: 2810933-8
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  • 6
    Online Resource
    Online Resource
    Direct taxation and the single European market
    Elsevier BV ; 1991
    In:  European Management Journal Vol. 9, No. 3 ( 1991-9), p. 235-246
    Details
    In: European Management Journal, Elsevier BV, Vol. 9, No. 3 ( 1991-9), p. 235-246
    Type of Medium: Online Resource
    ISSN: 0263-2373
    URL: Article
    DOI: 10.1016/0263-2373(91)90003-9
    RVK:
    QA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1991
    detail.hit.zdb_id: 2013159-8
    detail.hit.zdb_id: 859497-1
    SSG: 3,2
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  • 7
    Online Resource
    Online Resource
    Nitrate regulates floral induction in Arabidopsis, acting independently of light, gibberellin and autonomous pathways
    Springer Science and Business Media LLC ; 2011
    In:  Planta Vol. 233, No. 3 ( 2011-3), p. 539-552
    Details
    In: Planta, Springer Science and Business Media LLC, Vol. 233, No. 3 ( 2011-3), p. 539-552
    Type of Medium: Online Resource
    ISSN: 0032-0935 , 1432-2048
    URL: Article
    DOI: 10.1007/s00425-010-1316-5
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 1463030-8
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform
    Springer Science and Business Media LLC ; 2021
    In:  Nature Communications Vol. 12, No. 1 ( 2021-05-25)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-05-25)
    Abstract: Computational modeling and human studies suggest that transcranial alternating current stimulation (tACS) modulates alpha oscillations by entrainment. Yet, a direct examination of how tACS interacts with neuronal spiking activity that gives rise to the alpha oscillation in the thalamo-cortical system has been lacking. Here, we demonstrate how tACS entrains endogenous alpha oscillations in head-fixed awake ferrets. We first show that endogenous alpha oscillations in the posterior parietal cortex drive the primary visual cortex and the higher-order visual thalamus. Spike-field coherence is largest for the alpha frequency band, and presumed fast-spiking inhibitory interneurons exhibit strongest coupling to this oscillation. We then apply alpha-tACS that results in a field strength comparable to what is commonly used in humans ( 〈 0.5 mV/mm). Both in these ferret experiments and in a computational model of the thalamo-cortical system, tACS entrains alpha oscillations by following the theoretically predicted Arnold tongue. Intriguingly, the fast-spiking inhibitory interneurons exhibit a stronger entrainment response to tACS in both the ferret experiments and the computational model, likely due to their stronger endogenous coupling to the alpha oscillation. Our findings demonstrate the in vivo mechanism of action for the modulation of the alpha oscillation by tACS.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-021-23021-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2553671-0
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  • 9
    Online Resource
    Online Resource
    Stimulus-specific regulation of visual oddball differentiation in posterior parietal cortex
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-08-18)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-08-18)
    Abstract: The frequency at which a stimulus is presented determines how it is interpreted. For example, a repeated image may be of less interest than an image that violates the prior sequence. This process involves integration of sensory information and internal representations of stimulus history, functions carried out in higher-order sensory areas such as the posterior parietal cortex (PPC). Thus far, there are few detailed reports investigating the single-neuron mechanisms for processing of stimulus presentation frequency in PPC. To address this gap in knowledge, we recorded PPC activity using 2-photon calcium imaging and electrophysiology during a visual oddball paradigm. Calcium imaging results reveal differentiation at the level of single neurons for frequent versus rare conditions which varied depending on whether the stimulus was preferred or non-preferred by the recorded neural population. Such differentiation of oddball conditions was mediated primarily by stimulus-independent adaptation in the frequent condition.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-70448-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 10
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    Online Resource
    The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis
    Association for Research in Vision and Ophthalmology (ARVO) ; 2003
    In:  Investigative Opthalmology & Visual Science Vol. 44, No. 10 ( 2003-10-01), p. 4457-
    Details
    In: Investigative Opthalmology & Visual Science, Association for Research in Vision and Ophthalmology (ARVO), Vol. 44, No. 10 ( 2003-10-01), p. 4457-
    Type of Medium: Online Resource
    ISSN: 1552-5783
    URL: Article
    DOI: 10.1167/iovs.02-1063
    Language: English
    Publisher: Association for Research in Vision and Ophthalmology (ARVO)
    Publication Date: 2003
    detail.hit.zdb_id: 2009858-3
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