GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 10 ( 2019-7-19)
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606827-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    Cold Spring Harbor Laboratory ; 2006
    In:  RNA Vol. 12, No. 1 ( 2006-01), p. 177-184
    In: RNA, Cold Spring Harbor Laboratory, Vol. 12, No. 1 ( 2006-01), p. 177-184
    Abstract: RNA–RNA interactions play a crucial role at many different levels of the cellular metabolism such as plasmid replication control, viral encapsidation, or transcriptional and translational regulation. Therefore, methods are necessary to investigate the molecular determinants of given interactions, including their stabilities, or to screen for new interacting partners. We designed an RNA-hybrid system in S. cerevisiae , based on the yeast three-hybrid system. In this setup, the activation of a reporter gene is dependent on the interaction of two RNAs. A loop–loop interaction similar to the dimerization initiation site of the HIV genome was used as a model system, demonstrating that in this novel RNA-hybrid system only cognate RNAs promote the activation of the reporter gene. Levels of reporter activation correlate well with interaction stabilities determined in vitro by UV melting analyses, suggesting that conditions used for the analysis of in vitro structural stabilities translate well into the intracellular environment. Furthermore, the system was applicable for a screen against a test library. Nine out of ten selected clones were identified as predicted interaction partners for the bait RNA. In summary, we present a yeast reporter system depending on RNA–RNA interactions, which can be used alternatively for analysis of known interactions or for screening libraries in search for new interaction partners.
    Type of Medium: Online Resource
    ISSN: 1355-8382 , 1469-9001
    Language: English
    Publisher: Cold Spring Harbor Laboratory
    Publication Date: 2006
    detail.hit.zdb_id: 1475737-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 1997
    In:  Journal of Geophysical Research: Oceans Vol. 102, No. C2 ( 1997-02-15), p. 3371-3382
    In: Journal of Geophysical Research: Oceans, American Geophysical Union (AGU), Vol. 102, No. C2 ( 1997-02-15), p. 3371-3382
    Abstract: The Eurasian shelves supply water to the Nansen Basin intermediate layers in two ways: as buoyancy‐driven plumes of dense winter water and as permanent inflow of the Barents Sea branch of Atlantic Water. While the plumes are local and seasonal phenomena, the Barents Sea flow is part of the large‐scale circulation. Both interact with Atlantic Water, which enters the Arctic Ocean through Fram Strait and moves as a subsurface boundary current eastward along the continental slope. During the Polarstern cruise ARK IX/4 in summer 1993, the Fram Strait branch was observed as a narrow core within tens of kilometers of the Barents Sea shelf edge. Here, several patches of cold, low‐salinity water spread across the slope down to about 500 m depth. Their origin is assumed to be the northern Barents Sea. They mix with the warm, saline Fram Strait branch water (FSBW), so that the core properties of the latter become modified downstream. In the eastern Nansen Basin the Fram Strait branch is displaced toward the inner basin by inflow of the Barents Sea Branch of Atlantic Water (BSBW). This inflow appears as a broad (200 km) wedge extending from 200 to 1300 m depth. BSBW is colder and less saline than water of the Fram Strait branch, and it is less dense and less stratified than the ambient water. Both branches appear to undergo vigorous mixing while spreading eastward, so that any eastward continuation of the boundary flow transports about 50% BSBW and 50% FSBW above 600 m and about 80% BSBW and 20% FSBW below that level toward the Canadian Basin. According to available observations, the Barents and Kara Seas are the only source areas for shelf waters ventilating the Nansen Basin below the halocline, and these waters constitute a freshwater input rather than a salt input. Winter shelf water from the Laptev Sea cannot contribute to layers deeper than the upper halocline.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1997
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 3094104-0
    detail.hit.zdb_id: 2130824-X
    detail.hit.zdb_id: 2016813-5
    detail.hit.zdb_id: 2016810-X
    detail.hit.zdb_id: 2403298-0
    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 161666-3
    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 2969341-X
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094268-8
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 3094181-7
    detail.hit.zdb_id: 3094219-6
    detail.hit.zdb_id: 3094167-2
    detail.hit.zdb_id: 2220777-6
    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    In: Journal of Clinical Medicine, MDPI AG, Vol. 10, No. 22 ( 2021-11-22), p. 5464-
    Abstract: Transcutaneous spinal cord stimulation (tSCS) is a promising intervention that can benefit spasticity control and augment voluntary movement in spinal cord injury (SCI) and multiple sclerosis. Current applications require expert knowledge and rely on the thorough visual analysis of electromyographic (EMG) responses from lower-limb muscles to optimize attainable treatment effects. Here, we devised an automated tSCS setup by combining an electrode array placed over low-thoracic to mid-lumbar vertebrae, synchronized EMG recordings, and a self-operating stimulation protocol to systematically test various stimulation sites and amplitudes. A built-in calibration procedure classifies the evoked responses as reflexes or direct motor responses and identifies stimulation thresholds as recommendations for tSCS therapy. We tested our setup in 15 individuals (five neurologically intact, five SCI, and five Parkinson’s disease) and validated the results against blinded ratings from two clinical experts. Congruent results were obtained in 13 cases for electrode positions and in eight for tSCS amplitudes, with deviations of a maximum of one position and 5 to 10 mA in amplitude in the remaining cases. Despite these minor deviations, the calibration found clinically suitable tSCS settings in 13 individuals. In the remaining two cases, the automatic setup and both experts agreed that no reflex responses could be detected. The presented technological developments may facilitate the dissemination of tSCS into non-academic environments and broaden its use for diagnostic and therapeutic purposes.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662592-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    American Meteorological Society ; 2019
    In:  Journal of Physical Oceanography Vol. 49, No. 9 ( 2019-09), p. 2309-2321
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 49, No. 9 ( 2019-09), p. 2309-2321
    Abstract: Ocean water is freshwater with salt. The distribution of salt concentration in the ocean changes by addition and removal of freshwater in the form of precipitation, continental runoff, and evaporation, and by a flow of saline ocean water that gives rise to a salt flux divergence. Often, changes in salinity are described in terms of “freshwater content” changes and oceanic “freshwater transports,” defined as fractions of freshwater. But these freshwater fractions are arbitrary, because they are defined by a nonunique reference salinity. Also all temporal and spatial comparisons and anomalies of such freshwater fractions in the ocean depend on the choice of reference salinity in a nonlinear way, because in the definition of the fraction it appears in the denominator. Consequently, any conclusion based on the comparison of freshwater fractions is ambiguous. Since there is no definite physical constraint for a unique reference salinity, freshwater fractions are declared not useful for the assessment of the state of ocean regions and the associated changes. In the light of ongoing changes in the water cycle and the global nature of climate science, scientific results need to be expressed in a way so that they can be easily compared and integrated in a global perspective. To this end, we recommend to avoid freshwater fraction as a parameter describing the ocean state. Instead, one should use the terms of the salt budget to obtain unique results for quantifying and comparing salinity.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2019
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    In: Journal of Geophysical Research: Oceans, American Geophysical Union (AGU), Vol. 125, No. 5 ( 2020-05)
    Abstract: The Transpolar Drift is a source of shelf‐ and river‐derived elements to the central Arctic Ocean The TPD is rich in dissolved organic matter (DOM), which facilitates long‐range transport of trace metals that form complexes with DOM Margin trace element fluxes may increase with future Arctic warming due to DOM release from permafrost thaw and increasing river discharge
    Type of Medium: Online Resource
    ISSN: 2169-9275 , 2169-9291
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 3094219-6
    SSG: 16,13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 1997
    In:  Journal of Geophysical Research: Oceans Vol. 102, No. C4 ( 1997-04-15), p. 8467-8483
    In: Journal of Geophysical Research: Oceans, American Geophysical Union (AGU), Vol. 102, No. C4 ( 1997-04-15), p. 8467-8483
    Abstract: We combine results from hydrographic measurements and numerical models to investigate the circulation in the Arctic Ocean. Observations exhibit a marked difference in the temperature and salinity distribution west and east of the St. Anna Trough. West of the St. Anna Trough the warm and saline core of the Fram Strait branch is found close to the shelf break. East of the St. Anna Trough the highest temperatures and salinities are found further off shore. A colder, relatively fresh layer of Barents Sea outflow displaces the Fram Strait branch. The numerical model reproduces these hydrographic structures. It depicts the Barents Sea branch as the most important inflow into the Arctic with respect to heat, fresh water, and volume. The divergence of the heat transport in the Barents Sea is as great as the net heat transport into the Arctic Ocean. A large part of the freshwater input takes place in the area of the Barents/Kara Sea. The model transports associated with the Fram Strait branch are smaller because most of the Atlantic water recirculates in Fram Strait. Bottom topography plays a crucial role for the model circulation. Our results support previous conceptual models of the Atlantic layer circulation in the Arctic Ocean. The model circulation is mainly thermohaline driven. Ventilation times for the Eurasian and Canadian Basins below 1‐km depth are estimated as 220 and 420 years, respectively.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1997
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 3094104-0
    detail.hit.zdb_id: 2130824-X
    detail.hit.zdb_id: 2016813-5
    detail.hit.zdb_id: 2016810-X
    detail.hit.zdb_id: 2403298-0
    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 161666-3
    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 2969341-X
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094268-8
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 3094181-7
    detail.hit.zdb_id: 3094219-6
    detail.hit.zdb_id: 3094167-2
    detail.hit.zdb_id: 2220777-6
    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    In: Sarcoma, Hindawi Limited, Vol. 6, No. 4 ( 2002), p. 141-143
    Abstract: We describe a patient who underwent thoracic radiation therapy for biopsy-proven pulmonary spindle cell sarcoma in the left lower lobe, 15 months after birth. At the age of 37 she developed shoulder pain, fatigue, and progressive exertion dyspnoea. Chest X-ray revealed a pulmonary mass in the left lower lobe due to a cytology-proven malignant tumour.The patient underwent left pneumonectomy. Histology revealed a myosarcoma of the lung, similar to the previous sarcoma. Furthermore, the patient was diagnosed to have Turner syndrome mosaic and chromosomal analysis revealed a translocation t(1;13) in 3/50 metaphases. However a germline mutation of the p53 tumour suppressor gene was excluded. After 2 years of follow-up the patient is stable and there are no signs of recurrence of the tumour.We conclude a re-occurrence of this very rare malignant disorder of the lung after a 36-year interval in a patient with Turner syndrome mosaic. Following initial curative radiation therapy, with a remission over 36 years, lung resection was now successfully performed.
    Type of Medium: Online Resource
    ISSN: 1357-714X , 1369-1643
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2002
    detail.hit.zdb_id: 2011839-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    In: Deep Sea Research Part I: Oceanographic Research Papers, Elsevier BV, Vol. 79 ( 2013-09), p. 156-168
    Type of Medium: Online Resource
    ISSN: 0967-0637
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1500309-7
    detail.hit.zdb_id: 1146810-5
    SSG: 14
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    In: Deep Sea Research Part I: Oceanographic Research Papers, Elsevier BV, Vol. 58, No. 2 ( 2011-2), p. 173-185
    Type of Medium: Online Resource
    ISSN: 0967-0637
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 1500309-7
    detail.hit.zdb_id: 1146810-5
    SSG: 14
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...