In:
JCPP Advances, Wiley, Vol. 2, No. 4 ( 2022-12)
Abstract:
To reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulnerability to future suicidal ideation and behaviors (SIBs) in adolescence and young adulthood. In an international collaboration, grey and white matter structure was investigated in adolescent and young adult females with future suicidal behaviors ( f SB) and ideation ( f SI), and without SIBs ( f nonSIB). Methods Structural ( n = 91) and diffusion‐weighted ( n = 88) magnetic resonance imaging scans at baseline and SIB measures at follow‐up on average two years later (standard deviation, SD = 1 year) were assessed in 92 females [age(SD) = 16.1(2.6) years] with bipolar disorder (BD, 28.3%) or major depressive disorder (MDD, 71.7%). One‐way analyses of covariance comparing baseline regional grey matter cortical surface area, thickness, subcortical grey volumes, or white matter tensor‐based fractional anisotropy across f SB ( n = 40, 43.5%), f SI ( n = 33, 35.9%) and f nonSIB ( n = 19, 20.6%) groups were followed by pairwise comparisons in significant regions ( p 〈 0.05). Results Compared to f nonSIBs, f SIs and f SBs showed significant decreases in cortical thickness of right inferior frontal gyrus pars orbitalis and middle temporal gyrus, f SIs of left inferior frontal gyrus, pars orbitalis. F SIs and f SBs showed lower fractional anisotropy in left uncinate fasciculus and corona radiata, and f SBs in right uncinate and superior fronto‐occipital fasciculi. Conclusions The study provides preliminary evidence of grey and white matter alterations in brain regions subserving emotional and behavioral regulation and perceptual processing in adolescent and young adult females with mood disorders with, versus without, future SIBs. Findings suggest potential targets to prevent SIBs in female adolescents and young adults.
Type of Medium:
Online Resource
ISSN:
2692-9384
,
2692-9384
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
3045365-3
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