In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 141, No. 3 ( 2006), p. 223-229
Abstract:
〈 i 〉 Background: 〈 /i 〉 The CTLA-4 molecule is an important negative regulator of T cell activation. It is encoded on chromosome 2q33 and found to be associated with several allergic phenotypes including asthma. However, the association of 〈 i 〉 CTLA-4 〈 /i 〉 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study. 〈 i 〉 Methods: 〈 /i 〉 By PCR-RFLP, the distribution of three single nucleotide polymorphisms (SNPs), –1147 C/T, –318 C/T, and +49 A/G, was examined in 219 Polish Caucasoid patients diagnosed with allergic asthma and in 102 ethnically matched healthy control individuals. (AT) 〈 sub 〉 n 〈 /sub 〉 microsatellite polymorphism was also tested in the same individuals. 〈 i 〉 Results: 〈 /i 〉 No statistically significant differences in SNPs or microsatellite allele, genotype or haplotype frequencies between patients and controls were found. 〈 i 〉 Conclusion: 〈 /i 〉 CTLA-4 polymorphisms do not seem to be a risk factor for allergic asthma in Poles.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
2006
detail.hit.zdb_id:
1482722-0
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