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  • 1
    Online Resource
    Online Resource
    Peripheral Microneedle Patch for First‐Aid Hemostasis
    Wiley ; 2023
    In:  Advanced Healthcare Materials Vol. 12, No. 7 ( 2023-03)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 12, No. 7 ( 2023-03)
    Abstract: Despite the minimized puncture sizes and high efficiency, microneedle (MN) patches have not been used to inject hemostatic drugs into bleeding wounds because they easily destroy capillaries when a tissue is pierced. In this study, a shelf‐stable dissolving MN patch is developed to prevent rebleeding during an emergency treatment. A minimally and site‐selectively invasive hemostatic drug delivery system is established by using a peripheral MN (p‐MN) patch that does not directly intrude the wound site but enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is histologically examined by using a bleeding liver of a Sprague–Dawley (SD) rat as an extreme wound model in vivo. The skin penetration force is quantified to demonstrate that the administration of the p‐MN patch is milder than that of the conventional MN patch. Hemostatic performance is systematically studied by analyzing bleeding weight and time and comparing them with that of conventional hemostasis methods. The superior performance of a p‐MN for the heparin‐pretreated SD rat model is demonstrated by intravenous injection in vivo.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v12.7
    DOI: 10.1002/adhm.202201697
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 2
    Online Resource
    Online Resource
    In vitro synergistic potentials of novel antibacterial combination therapies against Salmonella enterica serovar Typhimurium
    Springer Science and Business Media LLC ; 2020
    In:  BMC Microbiology Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Microbiology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: The antibiotics generally used in farm animals are rapidly losing their effectiveness all over the world as bacteria develop antibiotic resistance. Like some other pathogenic bacteria multidrug-resistant strains of Salmonella enterica serovar Typhimurium ( S. Typhimurium) are also frequently found in animals and humans which poses a major public health concern. New strategies are needed to block the development of resistance and to prolong the life of traditional antibiotics. Thus, this study aimed to increase the efficacy of existing antibiotics against S. Typhimurium by combining them with opportunistic phenolic compounds gallic acid (GA), epicatechin, epicatechin gallate, epigallocatechin and hamamelitannin. Fractional inhibitory concentration indexes (FICI) of phenolic compound-antibiotic combinations against S. Typhimurium were determined. Based on the FICI and clinical importance, 1 combination (GA and ceftiofur) was selected for evaluating its effects on the virulence factors of this bacterium. Viability of Rattus norvegicus (IEC-6) cell in presence of this antibacterial combination was evaluated. Results Minimum inhibitory concentrations (MICs) of GA, epigallocatechin and hamamelitannin found against different strains of S. Typhimurium were 256, (512–1024), and (512–1024) μg/mL, respectively. Synergistic antibacterial effect was obtained from the combination of erythromycin-epicatechin gallate (FICI: 0.50) against S. Typhimurium. Moreover, additive effects (FICI: 0.502–0.750) were obtained from 16 combinations against this bacterium. The time-kill assay and ultrastructural morphology showed that GA-ceftiofur combination more efficiently inhibited the growth of S. Typhimurium compared to individual antimicrobials. Biofilm viability, and swimming and swarming motilities of S. Typhimurium in presence of GA-ceftiofur combination were more competently inhibited than individual antimicrobials. Viabilities of IEC-6 cells were more significantly enhanced by GA-ceftiofur combinations than these antibacterials alone. Conclusions This study suggests that GA-ceftiofur combination can be potential medication to treat S. Typhimurium-associated diarrhea and prevent S. Typhimurium-associated blood-stream infections (e.g.: fever) in farm animals, and ultimately its transmission from animal to human. Further in vivo study to confirm these effects and safety profiles in farm animal should be undertaken for establishing these combinations as medications.
    Type of Medium: Online Resource
    ISSN: 1471-2180
    URL: Article
    DOI: 10.1186/s12866-020-01810-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041505-9
    SSG: 12
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds against Escherichia coli
    MDPI AG ; 2020
    In:  Pathogens Vol. 9, No. 10 ( 2020-10-03), p. 811-
    Details
    In: Pathogens, MDPI AG, Vol. 9, No. 10 ( 2020-10-03), p. 811-
    Abstract: Pathogenic Escherichia coli (E. coli)-associated infections are becoming difficult to treat because of the rapid emergence of antibiotic-resistant strains. Novel approaches are required to prevent the progression of resistance and to extend the lifespan of existing antibiotics. This study was designed to improve the effectiveness of traditional antibiotics against E. coli using a combination of the gallic acid (GA), hamamelitannin, epicatechin gallate, epigallocatechin, and epicatechin. The fractional inhibitory concentration index (FICI) of each of the phenolic compound-antibiotic combinations against E. coli was ascertained. Considering the clinical significance and FICI, two combinations (hamamelitannin-erythromycin and GA-ampicillin) were evaluated for their impact on certain virulence factors of E. coli. Finally, the effects of hamamelitannin and GA on Rattus norvegicus (IEC-6) cell viability were investigated. The FICIs of the antibacterial combinations against E. coli were 0.281–1.008. The GA-ampicillin and hamamelitannin-erythromycin combinations more effectively prohibited the growth, biofilm viability, and swim and swarm motilities of E. coli than individual antibiotics. The concentration of hamamelitannin and GA required to reduce viability by 50% (IC50) in IEC-6 cells was 988.54 μM and 564.55 μM, correspondingly. GA-ampicillin and hamamelitannin-erythromycin may be potent combinations and promising candidates for eradicating pathogenic E. coli in humans and animals.
    Type of Medium: Online Resource
    ISSN: 2076-0817
    URL: Article
    DOI: 10.3390/pathogens9100811
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2695572-6
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  • 4
    Online Resource
    Online Resource
    ADC: Advanced document clustering using contextualized representations
    Elsevier BV ; 2019
    In:  Expert Systems with Applications Vol. 137 ( 2019-12), p. 157-166
    Details
    In: Expert Systems with Applications, Elsevier BV, Vol. 137 ( 2019-12), p. 157-166
    Type of Medium: Online Resource
    ISSN: 0957-4174
    URL: Article
    DOI: 10.1016/j.eswa.2019.06.068
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1041179-3
    detail.hit.zdb_id: 2017237-0
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  • 5
    Online Resource
    Online Resource
    Wafer-Scale Growth of a MoS2 Monolayer via One Cycle of Atomic Layer Deposition: An Adsorbate Control Method
    American Chemical Society (ACS) ; 2021
    In:  Chemistry of Materials Vol. 33, No. 11 ( 2021-06-08), p. 4099-4105
    Details
    In: Chemistry of Materials, American Chemical Society (ACS), Vol. 33, No. 11 ( 2021-06-08), p. 4099-4105
    Type of Medium: Online Resource
    ISSN: 0897-4756 , 1520-5002
    URL: Article
    URL: Article
    DOI: 10.1021/acs.chemmater.1c00729
    DOI: 10.1021/acs.chemmater.1c00729.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2021
    detail.hit.zdb_id: 1500399-1
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  • 6
    Online Resource
    Online Resource
    Electrosynthesis of Dihydropyrano[4,3‐ b ]indoles Based on a Double Oxidative [3+3] Cycloaddition
    Wiley ; 2020
    In:  Angewandte Chemie Vol. 132, No. 29 ( 2020-07-13), p. 11984-11989
    Details
    In: Angewandte Chemie, Wiley, Vol. 132, No. 29 ( 2020-07-13), p. 11984-11989
    Abstract: Oxidative [3+3] cycloadditions offer an efficient route for six‐membered‐ring formation. This approach has been realized based on an electrochemical oxidative coupling of indoles/enamines with active methylene compounds followed by tandem 6π‐electrocyclization leading to the synthesis of dihydropyrano[4,3‐ b ]indoles and 2,3‐dihydrofurans. The radical–radical cross‐coupling of the radical species generated by anodic oxidation combined with the cathodic generation of the base from O 2 allows for mild reaction conditions for the synthesis of structurally complex heterocycles.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v132.29
    DOI: 10.1002/ange.202003364
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 7
    Online Resource
    Online Resource
    Electrosynthesis of Dihydropyrano[4,3‐ b ]indoles Based on a Double Oxidative [3+3] Cycloaddition
    Wiley ; 2020
    In:  Angewandte Chemie International Edition Vol. 59, No. 29 ( 2020-07-13), p. 11886-11891
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 59, No. 29 ( 2020-07-13), p. 11886-11891
    Abstract: Oxidative [3+3] cycloadditions offer an efficient route for six‐membered‐ring formation. This approach has been realized based on an electrochemical oxidative coupling of indoles/enamines with active methylene compounds followed by tandem 6π‐electrocyclization leading to the synthesis of dihydropyrano[4,3‐ b ]indoles and 2,3‐dihydrofurans. The radical–radical cross‐coupling of the radical species generated by anodic oxidation combined with the cathodic generation of the base from O 2 allows for mild reaction conditions for the synthesis of structurally complex heterocycles.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v59.29
    DOI: 10.1002/anie.202003364
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 8
    Online Resource
    Online Resource
    Bi-modal near-infrared fluorescence and ultrasound imaging via a transparent ultrasound transducer for sentinel lymph node localization
    Optica Publishing Group ; 2022
    In:  Optics Letters Vol. 47, No. 2 ( 2022-01-15), p. 393-
    Details
    In: Optics Letters, Optica Publishing Group, Vol. 47, No. 2 ( 2022-01-15), p. 393-
    Abstract: Sentinel lymph node biopsy with an indocyanine green-based near-infrared fluorescence imaging system avoids the shortcomings of using a radioisotope or a combination of a blue dye and a radioactive tracer. To improve surgical precision, recent research has provided a depth profile of the sentinel lymph node by fusing fluorescence and ultrasound imaging. Here, we present a combined near-infrared fluorescence and ultrasound imaging system based on a transparent ultrasound transducer. The transparent ultrasound transducer enables seamless coaxial alignment of the fluorescence and ultrasound beam paths, allowing bi-modal observation of a single region of interest. Further, we demonstrate that the sentinel lymph node of mice injected with indocyanine green can be successfully localized and dissected based on information from the bi-modal imaging system.
    Type of Medium: Online Resource
    ISSN: 0146-9592 , 1539-4794
    URL: Article
    DOI: 10.1364/OL.446041
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2022
    detail.hit.zdb_id: 243290-0
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  • 9
    Online Resource
    Online Resource
    Where Are the Crosshairs in the Finderscope? Another activity using a cardboard telescope
    American Association of Physics Teachers (AAPT) ; 2021
    In:  The Physics Teacher Vol. 59, No. 8 ( 2021-11-01), p. 656-658
    Details
    In: The Physics Teacher, American Association of Physics Teachers (AAPT), Vol. 59, No. 8 ( 2021-11-01), p. 656-658
    Abstract: A Finderscope is a low-power telescope with a relatively large field of view. It has the same line of sight as the main telescope, helping the main telescope easily find the target. One of the differences between a telescope and a finder is that the finder has crosshairs to aid in accurately pointing at a target. You can see the crosshairs and the object together clearly through the finderscope. If you add crosshairs to the telescope, can you see it as in a finder? If so, where should you put the crosshairs?
    Type of Medium: Online Resource
    ISSN: 0031-921X , 1943-4928
    URL: Article
    DOI: 10.1119/10.0006922
    Language: English
    Publisher: American Association of Physics Teachers (AAPT)
    Publication Date: 2021
    detail.hit.zdb_id: 2066897-1
    detail.hit.zdb_id: 391692-3
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  • 10
    Online Resource
    Online Resource
    Opto-ultrasound biosensor for wearable and mobile devices: realization with a transparent ultrasound transducer
    Optica Publishing Group ; 2022
    In:  Biomedical Optics Express Vol. 13, No. 9 ( 2022-09-01), p. 4684-
    Details
    In: Biomedical Optics Express, Optica Publishing Group, Vol. 13, No. 9 ( 2022-09-01), p. 4684-
    Abstract: Mobile and wearable healthcare electronics are widely used for measuring bio-signals using various fusion sensors that employ photoplethysmograms, cameras, microphones, ultrasound (US) sensors, and accelerometers. However, the consumer demand for small form factors has significantly increased as the integration of multiple sensors is difficult in small mobile or wearable devices. This study proposes two novel opto-US sensors, namely (1) a wearable photoplethysmography (PPG)-US device and (2) a PPG sensor built-in mobile smartphone with a US sensor, seamlessly integrated using a transparent ultrasound transducer (TUT). The TUT exhibits a center frequency of 6 MHz with a 50% bandwidth and 82% optical transparency in visible and near-infrared regions. We developed an integrated wearable PPG-US device to demonstrate its feasibility and coupled the TUT sensor with a smartphone. We measured the heart rates optically and acoustically in human subjects and quantified the oxygen saturation optically by passing light through the TUT. The proposed proof-of-concept is a novel sensor fusion for mobile and wearable devices that require a small form factor and aim to improve digital healthcare. The results of this study can form the basis for innovative developments in sensor-based high-tech industrial applications, such as automobiles, robots, and drones, in addition to healthcare applications.
    Type of Medium: Online Resource
    ISSN: 2156-7085 , 2156-7085
    URL: Article
    DOI: 10.1364/BOE.468969
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2022
    detail.hit.zdb_id: 2572216-5
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