In:
Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 21, No. 7 ( 2012-07-01), p. 1171-1175
Abstract:
Background: If height is a well-established risk factor for breast cancer, leg length and sitting height are usually considered as better candidate biomarkers of growth hormone exposure than height, respectively, in pre- and postpuberty. Methods: Risk of breast cancer associated with quartiles of height, sitting height, and leg length were estimated in the French E3N cohort (N = 50,704, including 2,065 breast cancer cases), stratified on both menopausal and hormone receptor statuses. Results: Height was associated with an increased postmenopausal breast cancer risk [HR = 1.22 (1.06–1.41) when comparing extreme categories, Ptrend = 0.002], which was exclusively driven by the association with leg length [HR = 1.21 (1.05–1.39), Ptrend = 0.013] and not sitting height [HR = 1.03 (0.89–1.18), Ptrend = 0.379]. Leg length was associated with an increased ER+ breast cancer risk in postmenopausal [HR = 1.24 (1.06–1.46), Ptrend = 0.004] , whereas sitting height was associated with a borderline decreased ER− premenopausal breast cancer risk [HR = 0.45 (0.20–1.01), Ptrend = 0.011]. The positive associations observed in the overall population between leg length and breast cancer risk were actually restricted to women who had a short birth length [HR = 1.82 (1.22–2.72), Ptrend = 0.022] and those with a low birth weight [HR = 1.43 (1.00–2.04), Ptrend = 0.054]. Conclusion: The two components of height risk are differentially associated with breast cancer risk: leg length with an increased risk of postmenopausal ER+ tumors and sitting height with a decreased risk of premenopausal ER− tumors. Impact: Future prospective studies should no longer consider height a single risk factor for breast cancer risk. Cancer Epidemiol Biomarkers Prev; 21(7); 1171–5. ©2012 AACR.
Type of Medium:
Online Resource
ISSN:
1055-9965
,
1538-7755
DOI:
10.1158/1055-9965.EPI-12-0130
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2012
detail.hit.zdb_id:
2036781-8
detail.hit.zdb_id:
1153420-5
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