In:
Angewandte Chemie, Wiley, Vol. 129, No. 3 ( 2017-01-16), p. 746-750
Abstract:
A method for the decarboxylative macrocyclization of peptides bearing N‐terminal Michael acceptors has been developed. This synthetic method enables the efficient synthesis of cyclic peptides containing γ‐amino acids and is tolerant of functionalities present in both natural and non‐proteinogenic amino acids. Linear precursors ranging from 3 to 15 amino acids cyclize effectively under this photoredox method. To demonstrate the preparative utility of this method in the context of bioactive molecules, we synthesized COR‐005, a somatostatin analogue that is currently in clinical trials.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201608207
Language:
English
Publisher:
Wiley
Publication Date:
2017
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514305-6
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505872-7
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1479266-7
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