In:
Polymers and Polymer Composites, SAGE Publications, Vol. 21, No. 2 ( 2013-02), p. 79-84
Abstract:
To evaluate the biological safety of composite materials based on poly(L-lactide-co-glycolide) (PLGA) and bioactive glass (BG), which have a potential application in tissue engineering, the in-vivo biological properties were investigated by applying the micronucleus test, acute systemic toxicity test, haemolytic test and pyrogen measurement. The results indicated that the PLGA/BG composite showed no genetic toxicity; there was no toxicosis or death observed in the acute systemic toxicity test. The haemolytic test suggested that the PLGA/BG composite, with a haemolytic index of 0.281%, did not have an obvious haemolytic reaction. In addition, the PLGA/BG composite materials showed no pyrogen reaction. Therefore, PLGA/BG composite materials could be promising candidate biomedical materials for bone tissue engineering.
Type of Medium:
Online Resource
ISSN:
0967-3911
,
1478-2391
DOI:
10.1177/096739111302100204
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2099644-5
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