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  • 1
    Online Resource
    Online Resource
    A dataset of hourly profile soil temperature at Hailun Ecological Station in Northeast black soil region during 2010-2020
    Computer Network Information Center, Chinese Academy of Sciences ; 2023
    In:  China Scientific Data Vol. 8, No. 1 ( 2023-3-31)
    Details
    In: China Scientific Data, Computer Network Information Center, Chinese Academy of Sciences, Vol. 8, No. 1 ( 2023-3-31)
    Abstract: Soil temperature has a great influence on soil humification and mineralization, so it is of great significance to collect soil temperature observations at different spatial scales. Located in the core area of black soil, Hailun Agricultural Ecological Experiment Station (hereinafter referred to as Hailun Ecological Station) is a state-level long-term positioning research station of China Ecosystem Research Network. The soil temperature data of Hailun Ecological Station is of great significance for studying the soil water and heat process in black soil area. The data in this dataset are collected at Helen Ecological Station by the MILOS520 and MAWS301 automatic monitoring systems developed by VAISALA Company of Finland. We used the “Eco-meteorological Workstation” software process the observation data, and ensured the accuracy of the monitoring soil temperature data through analysis, inspection and reasonable optimization. This dataset consists of 11 data tables, namely the yearly soil temperature data of 11 years from 2010 to 2020, respectively. Each data table includes hourly soil temperature data of 0 cm, 5 cm, 10 cm, 15 cm, 20 cm, 40 cm, 60 cm and 100 cm. The publication of this dataset aims to provide scientific basis for the protection and long-term use of black soil.
    Type of Medium: Online Resource
    ISSN: 2096-2223
    URL: Article
    DOI: 10.11922/11-6035.csd.2022.0095.zh
    Language: Unknown
    Publisher: Computer Network Information Center, Chinese Academy of Sciences
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Handgrip weakness, systemic inflammation indicators, and overall survival in lung cancer patients with well performance status: A large multicenter observational study
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 3 ( 2023-02), p. 2818-2830
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 3 ( 2023-02), p. 2818-2830
    Abstract: Systemic inflammation and handgrip weakness have been used to predict mortality in many cancers. The purpose of current study was to evaluate the association of co‐occurrence of inflammation indicators and handgrip weakness with overall survival (OS) of lung cancer (LC) patients with good performance status. Methods The cutoff points for handgrip strength (HGS) and the four inflammation indicators were calculated using Maxstat. The time‐dependent receiver operating characteristic curve and C‐index were used to select optimal inflammation indicator for predicting OS of LC patients. The Cox proportional hazard regression model was used to calculate the hazard ratio (HR) of mortality. Kaplan–Meier curves were constructed to evaluate the association of indicators and the OS of LC patients. Results Among the 1951 patients, the mean ± standard deviation (SD) age was 60.6 ± 9.9 years, and 1300 (66.6%) patients were male. In patients with good performance status (PS), handgrip weakness (HR, 1.49; 95% confidence interval [95% CI], 1.30–1.70, p   〈  0.001) and low advanced lung cancer inflammation index (ALI) (HR, 2.05; 95%CI, 1.79–2.34, p   〈  0.001), high systemic immune‐inflammation index (SII) (HR, 1.91; 95%CI, 1.66–2.19, p   〈  0.001), high platelet: lymphocyte ratio (PLR) (HR, 1.60; 95%CI, 1.40–1.82, p   〈  0.001), or high neutrophil: lymphocyte ratio (NLR) (HR, 2.01; 95%CI, 1.76–2.30, p   〈  0.001) were associated with increased mortality risk of LC patients. ALI had better C‐index (0.624) and time‐AUC in the prediction of OS in LC patients with good PS than other three combinations. The co‐occurrence of handgrip weakness and low ALI more than doubled the risk of death in LC with good PS (HR, 2.44; 95% CI, 2.06–2.89, p   〈  0.001). Conclusion In LC patients who have good PS, patients with combined handgrip weakness and low ALI have the worst prognosis. The Trial Registration Number ChiCTR1800020329.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.3
    DOI: 10.1002/cam4.5180
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 3
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    Effects of Saccharides from Arctium lappa L. Root on FeCl 3 -Induced Arterial Thrombosis via the ERK/NF- κ B Signaling Pathway
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-03-25), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-03-25), p. 1-11
    Abstract: Saccharides from Arctium lappa. L. root (ALR-S) is a high-purity fructosaccharide separated from the medicinal plant Arctium lappa. L. root. These compounds showed many pharmacological effects in previous studies. In the present study, the antithrombotic effects of ALR-S in arterial thrombosis via inhibiting platelet adhesion and rebalancing thrombotic and antithrombotic factor expression and secretion were found in rats and human aortic endothelial cells (HAECs). This study also showed that inhibition of oxidative stress (OS), which is closely involved in the expression of coagulation- and thrombosis-related proteins, was involved in the antithrombotic effects of ALR-S. Furthermore, studies using FeCl 3 -treated HAECs showed that ALR-S induced the abovementioned effects at least partly by blocking the ERK/NF- κ B pathway. Moreover, U0126, a specific inhibitor of ERK, exhibited the same effects with ALR-S on a thrombotic process in FeCl 3 -injured HAECs, suggesting the thrombotic role of the ERK/NF- κ B pathway and the antithrombotic role of blocking the ERK/NF- κ B pathway by ALR-S. In conclusion, our study revealed that the ERK/NF- κ B pathway is a potential therapeutic target in arterial thrombosis and that ALR-S has good characteristics for the cure of arterial thrombosis via regulating the ERK/NF- κ B signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/7691352
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 4
    Online Resource
    Online Resource
    Data_Sheet_1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Nutrition Vol. 10 ( 2023-3-9)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 10 ( 2023-3-9)
    Abstract: Dairy products have long been regarded as a controversial nutrient for the skin. However, a clear demonstration of donkey milk (DM) on skincare is required. Methods In this study, spectrum and chemical component analyses were applied to DM. Then, the effects of DM on UVB-induced skin barrier damage and melanin pigmentation were first evaluated in vitro and in vivo . Cell survival, animal models, and expression of filaggrin (FLG) were determined to confirm the effect of DM on UVB-induced skin barrier damage. Melanogenesis and tyrosinase (TYR) activity were assessed after UVB irradiation to clarify the effect of DM on whitening activities. Further, a network pharmacology method was applied to study the interaction between DM ingredients and UVB-induced skin injury. Meanwhile, an analysis of the melanogenesis molecular target network was developed and validated to predict the melanogenesis regulators in DM. Results DM was rich in cholesterols, fatty acids, vitamins and amino acids. The results of evaluation of whitening activities in vitro and in vivo indicated that DM had a potent inhibitory effect on melanin synthesis. The results of effects of DM on UVB‑induced skin barrier damage indicated that DM inhibited UVB-induced injury and restored skin barrier function via up-regulation expression of FLG (filaggrin). The pharmacological network of DM showed that DM regulated steroid biosynthesis and fatty acid metabolism in keratinocytes and 64 melanin targets which the main contributing role of DM might target melanogenesis, cell adhesion molecules (CAMs), and Tumor necrosis factor (TNF) pathway. Discussion These results highlight the potential use of DM as a promising agent for whitening and anti-photoaging applications.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    URL: Article
    DOI: 10.3389/fnut.2023.1121498
    DOI: 10.3389/fnut.2023.1121498.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2776676-7
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  • 5
    Online Resource
    Online Resource
    Natural components in sunscreens: Topical formulations with sun protection factor (SPF)
    Elsevier BV ; 2021
    In:  Biomedicine & Pharmacotherapy Vol. 134 ( 2021-02), p. 111161-
    Details
    In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 134 ( 2021-02), p. 111161-
    Type of Medium: Online Resource
    ISSN: 0753-3322
    URL: Article
    DOI: 10.1016/j.biopha.2020.111161
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1501510-5
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  • 6
    Online Resource
    Online Resource
    Analysis of facial redness by comparing VISIA ® from Canfield and CSKIN ® from Yanyun Technology
    Wiley ; 2020
    In:  Skin Research and Technology Vol. 26, No. 5 ( 2020-09), p. 696-701
    Details
    In: Skin Research and Technology, Wiley, Vol. 26, No. 5 ( 2020-09), p. 696-701
    Abstract: Redness is the most common symptom among many facial dermatoses. With the rapid development of optical instruments, spectral imaging, and image processing technology, there appear varieties of skin color analysis methods and instruments. The aim of this study is to reveal the differences and correlations in measuring the facial redness between CSKIN ® and VISIA ® , as well as the relevance between the instrument parameters and clinical evaluation. Materials & Methods Forty‐three Chinese patients were enrolled. Images were taken and analyzed by VISIA ® from Canfield and CSKIN ® from Yanyun Technology, and the facial erythema was graded by the dermatologists. Results Feature counts within the red areas measured by VISIA ® were found to have significantly positive correlations with red pixels and percent which were measured by CSKIN ® on both sides of the face ( r  = .45 ~ .566, P  〈   .01). The parameters analyzed by CSKIN ® and VISIA ® feature counts were correlated with visual scores graded by the dermatologists, VISIA ® presented with a weak correlation ( r  = .213, P  〈  . 05), while CSKIN ® had a moderate correlation with the visual scores ( r  = .472 ~ .492, P  〈   .001). Conclusion CSKIN ® may be another alternative option when encountering with measurement and follow‐up of facial erythema.
    Type of Medium: Online Resource
    ISSN: 0909-752X , 1600-0846
    URL: Issue
    URL: Article
    DOI: 10.1111/srt.v26.5
    DOI: 10.1111/srt.12856
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2025540-8
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  • 7
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    Assessment of features in facial hyperpigmentation: Comparison study between VISIA and CSKIN
    Wiley ; 2022
    In:  Skin Research and Technology Vol. 28, No. 6 ( 2022-11), p. 846-850
    Details
    In: Skin Research and Technology, Wiley, Vol. 28, No. 6 ( 2022-11), p. 846-850
    Abstract: Hyperpigmentary disorder is one of the commonest skin concerns in dermatology clinics. The availability of noninvasive instruments provided a convenient, objective, and reproducible methodology for the evaluation of pigmentation and skin color. The aim of this study is to compare CSKIN and VISIA in measuring facial hyperpigmentation, as well as to assess the correlation between the instrumental analyzing and clinical evaluation. Methods Eighty Chinese patients were enrolled. Images were taken and analyzed by VISIA from Canfield and CSKIN from Yanyun Technology, and the facial hyperpigmentation was graded by three dermatologists. Results Feature counts within the facial pigmented areas analyzed by VISIA showed positive correlations with brown pixels ( r  = 0.331, p 〈  0.05) and brown percent ( r  = 0.395, p 〈  0.0001) measured by CSKIN. The parameters measured by CSKIN and VISIA were significantly correlated with visual scores graded by the dermatologists, with VISIA presenting a moderate correlation ( r  = 0.509, p   〈  0.001) and CSKIN a slightly stronger correlation with the visual scores ( r  = 0.653, p   〈  0.001). Conclusion CSKIN could serve as an alternative in the assessment and follow‐up of skin disease featuring with facial hyperpigmentation.
    Type of Medium: Online Resource
    ISSN: 0909-752X , 1600-0846
    URL: Issue
    URL: Article
    DOI: 10.1111/srt.v28.6
    DOI: 10.1111/srt.13216
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2025540-8
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  • 8
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    Online Resource
    β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 12 ( 2021-11-22)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-11-22)
    Abstract: Learning and memory impairment is a common clinical symptom of aging and nervous system injuries, and seriously affects quality of life. Memory impairment is associated with increased oxidative stress (OS) and inflammatory response. β-hydroxybutyrate (BHBA) is a water-soluble endogenous small-molecule ketone body that easily crosses the blood-brain barrier and has shown neuroprotection activities. In this study, we investigated the effects and mechanisms of BHBA on D-galactose (D-gal)-induced memory impairment in mice by in vitro and in vivo experiments. BHBA was administered intragastrically to D-gal-injured C57BL/6 mice for 42 days. Water maze performance, the morphology of the hippocampus with Nissl staining, the ACh content, OS, and inflammation status were examined. To further investigate the mechanism, hippocampal neuronal cells (HT22) were treated with BHBA with or without the SIRT1 inhibitor or small interfering RNAs against sirt1 (si-SIRT1) before incubation with D-gal. BHBA significantly improved water maze performance; increased the ACh content, SOD activity, and SIRT1 expression; and decreased AChE and LDH activity, ROS, MDA, IL-1β, TNF-α contents, and NLRP3 expression. Further studies with the SIRT inhibitor or siRNAs against sirt1 reversed the above effects of BHBA. Collectively, BHBA inhibited hippocampal OS and the inflammation process to alleviate learning and memory impairment through activating the SIRT1 pathway in D-gal-injured mice, suggesting that BHBA could be a potential option for drug development of learning and memory impairment induced by nervous system injuries.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2021.751028
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 9
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    Cover Image
    Wiley ; 2020
    In:  Skin Research and Technology Vol. 26, No. 5 ( 2020-09)
    Details
    In: Skin Research and Technology, Wiley, Vol. 26, No. 5 ( 2020-09)
    Type of Medium: Online Resource
    ISSN: 0909-752X , 1600-0846
    URL: Issue
    URL: Article
    DOI: 10.1111/srt.v26.5
    DOI: 10.1111/srt.12962
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2025540-8
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  • 10
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    A pilot study of lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell therapy in patients with advanced solid tumors
    Springer Science and Business Media LLC ; 2023
    In:  Nature Communications Vol. 14, No. 1 ( 2023-06-10)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-06-10)
    Abstract: Currently, the optimal lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell (Neo-T) therapy has yet to be determined. We report a single-arm, open-label and non-randomized phase 1 study (NCT02959905) of Neo-T therapy with lymphodepletion at various dose intensity in patients with locally advanced or metastatic solid tumors that are refractory to standard therapies. The primary end point is safety and the secondary end points are disease control rate (DCR), progression-free survival (PFS), overall survival (OS). Results show that the treatment is well tolerated with lymphopenia being the most common adverse event in the highest-intensity lymphodepletion groups. Neo-T infusion-related adverse events are only grade 1–2 in the no lymphodepletion group. The median PFS is 7.1 months (95% CI:3.7-9.8), the median OS is 16.8 months (95% CI: 11.9-31.7), and the DCR is 66.7% (6/9) among all groups. Three patients achieve partial response, two of them are in the no lymphodepletion group. In the group without lymphodepletion pretreatment, one patient refractory to prior anti-PD1 therapy shows partial response to Neo-T therapy. Neoantigen specific TCRs are examined in two patients and show delayed expansion after lymphodepletion treatment. In summary, Neo-T therapy without lymphodepletion could be a safe and promising regimen for advanced solid tumors.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-023-39225-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2553671-0
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