In:
Lipids, Wiley, Vol. 26, No. 12Part1 ( 1991-12), p. 1172-1174
Abstract:
From a series of amide analogs of the histamine H 1 antagonist, azatadine, a potent, orally active, dual platelet‐activating factor (PAF) and histamine antagonist, Sch 37370, namely 1‐acetyl‐4‐(8‐chloro‐5,6‐dihydro‐11 H ‐benzo‐[5,6]cyclohepta[1,2‐b] pyridin‐11‐ylidine)piperidine, was discovered. Sch 37370 selectively inhibits PAF‐induced aggregation of human platelets in vitro (IC 50 =0.6 μM), and in vivo inhibits PAF‐ and histamine‐induced bronchospasm in guinea pigs with ED 50 values of 6.0 and 2.4 mg/kg p.o., respectively. Sch 37370 is expected to be more efficacious than single mediator antagonists in allergic diseases, such as asthma.
Type of Medium:
Online Resource
ISSN:
0024-4201
,
1558-9307
Language:
English
Publisher:
Wiley
Publication Date:
1991
detail.hit.zdb_id:
2030265-4
SSG:
12
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