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  • 1
    Online Resource
    Online Resource
    Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
    Korean Association of Internal Medicine ; 2022
    In:  The Korean Journal of Internal Medicine Vol. 37, No. 5 ( 2022-09-01), p. 989-1001
    Details
    In: The Korean Journal of Internal Medicine, Korean Association of Internal Medicine, Vol. 37, No. 5 ( 2022-09-01), p. 989-1001
    Abstract: Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-19 vaccine-related pneumonitis (CV-P) and to review cases reported in the literature.Methods: We performed a prospective, observational case series analysis.Results: Eleven patients with a median age of 80 years were enrolled. Ten patients developed CV-P after BNT162b2-mRNA vaccination and one after ChAdOx1 nCoV-19 vaccination. We identified various patterns of CV-P, including transient infiltration, life-threatening acute respiratory distress syndrome, and aggravation of underlying interstitial lung disease. Most patients showed favorable outcomes with good responses to corticosteroid therapy.Conclusions: Identifying the mechanism of CV-P requires further investigation; however, radiological and laboratory findings in our case series support inflammatory dysregulation in the lung parenchyma after vaccination. Clinicians should consider CV-P in patients with atypical lung infiltration, no specific etiologies, and recent COVID-19 vaccination
    Type of Medium: Online Resource
    ISSN: 1226-3303 , 2005-6648
    URL: Article
    DOI: 10.3904/kjim.2022.072
    Language: English
    Publisher: Korean Association of Internal Medicine
    Publication Date: 2022
    detail.hit.zdb_id: 2500508-X
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  • 2
    Online Resource
    Online Resource
    Korean physician prescription patterns for home oxygen therapy in chronic obstructive pulmonary disease patients
    Korean Association of Internal Medicine ; 2022
    In:  The Korean Journal of Internal Medicine Vol. 37, No. 1 ( 2022-01-01), p. 119-126
    Details
    In: The Korean Journal of Internal Medicine, Korean Association of Internal Medicine, Vol. 37, No. 1 ( 2022-01-01), p. 119-126
    Abstract: Background/Aims: Hypoxemia in chronic obstructive pulmonary disease (COPD) leads to reduced ability to exercise, decreased quality of life, and, eventually, increased mortality. Home oxygen therapy in patients with severe COPD reduces distress symptoms and mortality rates. However, there have been few studies on physicians’ prescription behavior toward home oxygen therapy. Therefore, we investigated the respiratory specialists’ perspective on home oxygen therapy.Methods: In this cross-sectional, study, a questionnaire was completed by 30 pulmonary specialists who worked in tertiary hospitals and prescribed home oxygen therapy. The questionnaire consisted of 28 items, including 15 items on oxygen prescription for outpatients, four for inpatients, and nine on service improvement.Results: All physicians were prescribing less than 2 L/min of oxygen for either 24 (n = 10, 33.3%) or 15 hours (n = 9, 30.3%). All (n = 30) used pulse oximetry, 26 (86.7%) analyzed arterial blood gas. Thirteen physicians had imposed restrictions and recommended oxygen use only during exercise or sleep. Sixteen (53.3%) physicians were educating their patients about home oxygen therapy. Furthermore, physicians prescribed home oxygen to patients that did not fit the typical criteria for longterm oxygen therapy, with 30 prescribing it for acute relief and 17 for patients with borderline hypoxemia.Conclusions: This study identified the prescription pattern of home oxygen therapy in Korea. Respiratory physicians prescribe home oxygen therapy to hypoxemic COPD patients for at least 15 hours/day, and at a rate of less than 2 L/min. More research is needed to provide evidence for establishing policies on oxygen therapy in COPD patients.
    Type of Medium: Online Resource
    ISSN: 1226-3303 , 2005-6648
    URL: Article
    DOI: 10.3904/kjim.2020.470
    Language: English
    Publisher: Korean Association of Internal Medicine
    Publication Date: 2022
    detail.hit.zdb_id: 2500508-X
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  • 3
    Online Resource
    Online Resource
    Pretreatment Neutrophil-to-Lymphocyte Ratio and Smoking History as Prognostic Factors in Advanced Non–Small Cell Lung Cancer Patients Treated with Osimertinib
    The Korean Academy of Tuberculosis and Respiratory Diseases ; 2022
    In:  Tuberculosis and Respiratory Diseases Vol. 85, No. 2 ( 2022-04-01), p. 155-164
    Details
    In: Tuberculosis and Respiratory Diseases, The Korean Academy of Tuberculosis and Respiratory Diseases, Vol. 85, No. 2 ( 2022-04-01), p. 155-164
    Abstract: Background: The remarkable efficacy of osimertinib in non‒small cell lung cancer (NSCLC) with acquired T790M mutation has been widely documented in clinical trials and real-world practice. However, some patients show primary resistance to this drug. Even patients who initially show a favorable response have inconsistent clinical outcomes later. Therefore, the aim of this study was to identify additional clinical predictive factors for osimertinib efficacy.Methods: A prospective cohort of patients with acquired T790M positive stage IV lung adenocarcinoma treated with osimertinib salvage therapy in Hallym University Medical Center were analyzed.Results: Sixty-one eligible patients were analyzed, including 38 (62%) women and 39 (64%) who never smoked. Their mean age was 63.3 years. The median follow-up after treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) was 36.0 months (interquartile range, 24.7–50.2 months). The majority (n=45, 74%) of patients were deceased. Based on univariate analysis, low baseline neutrophil-to-lymphocyte ratios (NLR), age ≥50 years, never-smoking history, stage IVA at osimertinib initiation, and prolonged response to previous TKIs (≥10 months) were associated with a significantly longer progression-free survival (PFS). Multivariate analysis showed that never-smoking status (hazard ratio [HR], 0.54; 95% confidence interval [CI] , 0.30–0.98; p=0.041) and a baseline NLR less than or equal to 3.5 (HR, 0.23; 95% CI, 0.12–0.45; p 〈 0.001) were independently associated with a prolonged PFS with osimertinib.Conclusion: Smoking history and high NLR were independent negative predictors of osimertinib PFS in patients with advanced NSCLC developing EGFR T790M resistance after the initial EGFR-TKI treatment.
    Type of Medium: Online Resource
    ISSN: 1738-3536 , 2005-6184
    URL: Article
    DOI: 10.4046/trd.2021.0139
    Language: English
    Publisher: The Korean Academy of Tuberculosis and Respiratory Diseases
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea
    Springer Science and Business Media LLC ; 2020
    In:  BMC Cancer Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Cancer, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: The COVID-19 pandemic is predicted to significantly affect patients with lung cancer, owing to its rapid progression and high mortality. Studies on lung cancer diagnosis and treatment during an epidemic are lacking. We analyzed the impact of COVID-19 on lung cancer diagnosis in Korea, where lung cancer incidence continues to rise. Methods The number of newly diagnosed lung cancer cases in three university-affiliated hospitals during the pandemic and their clinical features were compared with lung cancer cases diagnosed during the same period in the past 3 years. The effectiveness of measures taken by the study hospitals to prevent nosocomial transmission was reviewed. Results A total of 612 patients were diagnosed with lung cancer from February through June, 2017–2020. During the pandemic, the number of patients who sought consultation at the division of pulmonology of study hospitals dropped by 16% from the previous year. Responding to the pandemic, the involved hospitals created physically isolated triage areas for patients with acute respiratory infection symptoms. Wide-range screening and preventive measures were implemented, thus minimizing the delay in lung cancer diagnosis. No patient acquired COVID-19 due to hospital exposure. The proportion of patients with stage III–IV non-small-cell lung cancer (NSCLC) significantly increased (2020: 74.7% vs. 2017: 57.9%, 2018: 66.7%, 2019: 62.7%, p  = 0.011). The number of lung cancers diagnosed during this period and the previous year remained the same. Conclusions The proportion of patients with advanced NSCLC increased during the COVID-19 pandemic.
    Type of Medium: Online Resource
    ISSN: 1471-2407
    URL: Article
    DOI: 10.1186/s12885-020-07544-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041352-X
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  • 5
    Online Resource
    Online Resource
    Eosinophilic fasciitis: A case report with a brief literature review
    XMLink ; 2020
    In:  Allergy, Asthma & Respiratory Disease Vol. 8, No. 2 ( 2020), p. 96-
    Details
    In: Allergy, Asthma & Respiratory Disease, XMLink, Vol. 8, No. 2 ( 2020), p. 96-
    Type of Medium: Online Resource
    ISSN: 2288-0402 , 2288-0410
    URL: Article
    DOI: 10.4168/aard.2020.8.2.96
    Language: Korean
    Publisher: XMLink
    Publication Date: 2020
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  • 6
    Online Resource
    Online Resource
    Changes in respiratory virus infection trends during the COVID-19 pandemic in South Korea: the effectiveness of public health measures
    Korean Association of Internal Medicine ; 2021
    In:  The Korean Journal of Internal Medicine Vol. 36, No. 5 ( 2021-09-01), p. 1157-1168
    Details
    In: The Korean Journal of Internal Medicine, Korean Association of Internal Medicine, Vol. 36, No. 5 ( 2021-09-01), p. 1157-1168
    Abstract: Background/Aims: Studies on the effectiveness of public health measures to prevent respiratory virus transmission in real-world settings are lacking. We investigated the effectiveness of universal mask use and adherence to other personal preventive measures on the changing viral respiratory infection patterns during the coronavirus disease 2019 (COVID-19) pandemic.Methods: Data were extracted from the South Korean National Respiratory Virus Sentinel Surveillance System. During the COVID-19 pandemic, a cross-sectional survey on adherence to personal preventive measures was conducted. Additionally, the number of subway passengers was analyzed to estimate physical distancing compliance.Results: During the pandemic, adherence to personal preventive measures significantly increased, particularly indoors and on public transportation. Respiratory virus trends were compared based on laboratory surveillance data of 47,675 patients with acute respiratory infections (2016 to 2020). The 2019 to 2020 influenza epidemic ended within 3 weeks, from the epidemic peak to the epidemic end, quickly ending the inf luenza season; with a 1.8- to 2.5-fold faster decline than in previous seasons. Previously, the overall respiratory virus positivity rate remained high after the influenza seasons had ended (47.7% to 69.9%). During the COVID-19 pandemic, this positive rate, 26.5%, was significantly lower than those in previous years. Hospital-based surveillance showed a decreased number of hospitalized patients with acute viral respiratory illnesses.Conclusions: This study suggests that high compliance to the use of personal preventive measures in public might reduce the incidence of all respiratory virus infections and its hospitalization rates, with no additional quarantine, isolation, or contact screening.
    Type of Medium: Online Resource
    ISSN: 1226-3303 , 2005-6648
    URL: Article
    DOI: 10.3904/kjim.2021.026
    Language: English
    Publisher: Korean Association of Internal Medicine
    Publication Date: 2021
    detail.hit.zdb_id: 2500508-X
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  • 7
    Online Resource
    Online Resource
    Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation
    Oxford University Press (OUP) ; 2022
    In:  Journal of Antimicrobial Chemotherapy Vol. 77, No. 5 ( 2022-04-27), p. 1353-1364
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 77, No. 5 ( 2022-04-27), p. 1353-1364
    Abstract: To explore extracorporeal membrane oxygenation (ECMO)-related alterations of the pharmacokinetics (PK) of piperacillin/tazobactam and determine an optimal dosage regimen for critically ill adult patients. Methods Population PK models for piperacillin/tazobactam were developed using a non-linear mixed effect modelling approach. The percentage of time within 24 h for which the free concentration exceeded the MIC at a steady-state (50%fT & gt;MIC, 100%fT & gt;MIC, and 100%fT & gt;4×MIC) for various combinations of dosage regimens and renal function were explored using Monte-Carlo simulation. Results A total of 226 plasma samples from 38 patients were used to develop a population PK model. Piperacillin/tazobactam PK was best described by two-compartment models, in which estimated glomerular filtration rate (eGFR), calculated using CKD-EPI equation based on cystatin C level, was a significant covariate for total clearance of each piperacillin and tazobactam. ECMO use decreased the central volume of distribution of both piperacillin and tazobactam in critically ill patients. Patients with Escherichia coli or Klebsiella pneumoniae infection, but not those with Pseudomonas aeruginosa infection, exhibited a PK/pharmacodynamic target attainment & gt;90% when the target is 50%fT & gt;MIC, as a result of applying the currently recommended dosage regimen. Prolonged or continuous infusion of 16 g/day was required when the treatment goal was 100%fT & gt;MIC or 100%fT & gt;4×MIC, and patients had an eGFR of 130–170 mL/min/1.73 m2. Conclusions ECMO use decreases piperacillin/tazobactam exposure. Prolonged or continuous infusion can achieve the treatment target in critically ill patients, particularly when MIC is above 8 mg/L or when patients have an eGFR of 130–170 mL/min/1.73 m2.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkac059
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1467478-6
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Population Pharmacokinetics of Meropenem in Critically Ill Korean Patients and Effects of Extracorporeal Membrane Oxygenation
    MDPI AG ; 2021
    In:  Pharmaceutics Vol. 13, No. 11 ( 2021-11-04), p. 1861-
    Details
    In: Pharmaceutics, MDPI AG, Vol. 13, No. 11 ( 2021-11-04), p. 1861-
    Abstract: Limited studies have investigated population pharmacokinetic (PK) models and optimal dosage regimens of meropenem for critically ill adult patients using the probability of target attainment, including patients receiving extracorporeal membrane oxygenation (ECMO). A population PK analysis was conducted using non-linear mixed-effect modeling. Monte Carlo simulation was used to determine for how long the free drug concentration was above the minimum inhibitory concentration (MIC) at steady state conditions in patients with various degrees of renal function. Meropenem PK in critically ill patients was described using a two-compartment model, in which glomerular filtration rate was identified as a covariate for clearance. ECMO did not affect meropenem PK. The simulation results showed that the current meropenem dosing regimen would be sufficient for attaining 40%fT 〉 MIC for Pseudomonas aeruginosa at MIC ≤ 4 mg/L. Prolonged infusion over 3 h or a high-dosage regimen of 2 g/8 h was needed for MIC 〉 2 mg/L or in patients with augmented renal clearance, for a target of 100%fT 〉 MIC or 100%fT 〉 4XMIC. Our study suggests that clinicians should consider prolonged infusion or a high-dosage regimen of meropenem, particularly when treating critically ill patients with augmented renal clearance or those infected with pathogens with decreased in vitro susceptibility, regardless of ECMO support.
    Type of Medium: Online Resource
    ISSN: 1999-4923
    URL: Article
    DOI: 10.3390/pharmaceutics13111861
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527217-2
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    COVID-19 vaccine-related interstitial lung disease: a case study
    BMJ ; 2022
    In:  Thorax Vol. 77, No. 1 ( 2022-01), p. 102-104
    Details
    In: Thorax, BMJ, Vol. 77, No. 1 ( 2022-01), p. 102-104
    Type of Medium: Online Resource
    ISSN: 0040-6376 , 1468-3296
    URL: Article
    DOI: 10.1136/thoraxjnl-2021-217609
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 1481491-2
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  • 10
    Online Resource
    Online Resource
    Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations
    Springer Science and Business Media LLC ; 2019
    In:  BMC Cancer Vol. 19, No. 1 ( 2019-12)
    Details
    In: BMC Cancer, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2019-12)
    Type of Medium: Online Resource
    ISSN: 1471-2407
    URL: Article
    DOI: 10.1186/s12885-019-5792-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2041352-X
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