In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-26), p. e0268969-
Abstract:
The current cut-off value for diagnosing exercise-induced bronchoconstriction (EIB) in adults—percent fall in FEV 1 (ΔFEV 1 ) ≥ 10% after exercise challenge test (ECT)—has low specificity and weak evidences. Therefore, this study aimed to identify the cut-off value for EIB that provides the highest diagnostic sensitivity and specificity. Participants who underwent the ECT between 2007 and 2018 were categorized according to ΔFEV 1 : definite EIB (ΔFEV 1 ≥ 15%), borderline (10% ≤ ΔFEV 1 〈 15%), and normal (ΔFEV 1 〈 10%). Distinct characteristics of the definite EIB group were identified and explored in the borderline EIB group. A receiver operating characteristic curve was plotted to determine the optimal cut-off value. Of 128 patients, 60 were grouped as the definite EIB group, 23 as the borderline group, and 45 as the normal group. All participants were men, with a median age of 20 years (interquartile range [IQR:] 19–23 years). The definite EIB group exhibited wheezing on auscultation ( P 〈 0.001), ΔFEV 1 /FVC ≥ 10% ( P 〈 0.001), and ΔFEF 25–75% ≥ 25% ( P 〈 0.001) compared to other groups. Eight (8/23, 34.8%) patients in the borderline group had at least one of these features, but the trend was more similar to that of the normal group than the definite EIB group. A cut-off value of ΔFEV 1 ≥ 13.5% had a sensitivity of 98.5% and specificity of 93.5% for EIB. Wheezing on auscultation, ΔFEV 1 /FVC ≥ 10%, and ΔFEF 25–75% ≥ 25% after ECT may be useful for the diagnosis of EIB, particularly in individuals with a ΔFEV 1 of 10–15%. For EIB, a higher cut-off value, possibly ΔFEV 1 ≥ 13.5%, should be considered as the diagnostic criterion.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0268969
DOI:
10.1371/journal.pone.0268969.g001
DOI:
10.1371/journal.pone.0268969.g002
DOI:
10.1371/journal.pone.0268969.g003
DOI:
10.1371/journal.pone.0268969.t001
DOI:
10.1371/journal.pone.0268969.t002
DOI:
10.1371/journal.pone.0268969.t003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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