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  • 1
    Online Resource
    Online Resource
    Reviewing benefits and costs of hydropower development evidence from the Lower Mekong River Basin
    Wiley ; 2019
    In:  WIREs Water Vol. 6, No. 4 ( 2019-07)
    Details
    In: WIREs Water, Wiley, Vol. 6, No. 4 ( 2019-07)
    Abstract: In this paper, we examine the benefits and costs of hydropower development in the Mekong River Basin. We compare four major reports—the Mekong River Commission's (MRC's) Basin Development Plan Programme, Phase 2 (BDP2), the Strategic Environmental Assessment of Hydropower on the Mekong Mainstream (SEA), the Study on the Impacts of Mainstream Hydropower on the Mekong River (MDS), and the MRC's recent council study (CS)—in order to provide the basis for a comparative analysis of the major impact evaluation literature on mainstream dam construction in the Mekong River Basin for the period of 2010–2018. The primary objective of the review is to identify points of agreement, disagreement, inconsistency, and knowledge gaps. Both Mekong River Commission reports (BDP2 and CS) suggest extensive economic benefits for proposed hydropower development, whereas the SEA and MDS indicate that the net impact would be negative. The projected impacts of hydropower development on fisheries, sediment flows, and ecosystems vary widely both in economic and biophysical terms. However, all four reports point to decreased food security and loss of local livelihoods for millions of people as major concerns related to dam development. While considerable resources have been devoted to producing these important studies, the lack of standardization across reports, especially assumptions and methodologies for economic impacts, frustrates efforts at meaningful comparison of their findings and precludes the prospect of clear analytical outcomes or policy impacts. This article is categorized under: Engineering Water 〉 Planning Water Human Water 〉 Value of Water Engineering Water 〉 Methods
    Type of Medium: Online Resource
    ISSN: 2049-1948 , 2049-1948
    URL: Issue
    URL: Article
    DOI: 10.1002/wat2.2019.6.issue-4
    DOI: 10.1002/wat2.1347
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2751191-1
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  • 2
    Online Resource
    Online Resource
    Large expert-curated database for benchmarking document similarity detection in biomedical literature search
    Oxford University Press (OUP) ; 2019
    In:  Database Vol. 2019 ( 2019-01-01)
    Details
    In: Database, Oxford University Press (OUP), Vol. 2019 ( 2019-01-01)
    Abstract: Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.
    Type of Medium: Online Resource
    ISSN: 1758-0463
    URL: Article
    DOI: 10.1093/database/baz085
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2496706-3
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  • 3
    Online Resource
    Online Resource
    26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2
    Springer Science and Business Media LLC ; 2017
    In:  BMC Neuroscience Vol. 18, No. S1 ( 2017-8)
    Details
    In: BMC Neuroscience, Springer Science and Business Media LLC, Vol. 18, No. S1 ( 2017-8)
    Type of Medium: Online Resource
    ISSN: 1471-2202
    URL: Article
    DOI: 10.1186/s12868-017-0371-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2041344-0
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  • 4
    Online Resource
    Online Resource
    Multi-messenger Observations of a Binary Neutron Star Merger
    American Astronomical Society ; 2017
    In:  The Astrophysical Journal Vol. 848, No. 2 ( 2017-10-16), p. L12-
    Details
    In: The Astrophysical Journal, American Astronomical Society, Vol. 848, No. 2 ( 2017-10-16), p. L12-
    Type of Medium: Online Resource
    ISSN: 2041-8213
    URL: Article
    DOI: 10.3847/2041-8213/aa91c9
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2017
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 2006858-X
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  • 5
    Online Resource
    Online Resource
    Shared Decision Making in Cardiac Electrophysiology Procedures and Arrhythmia Management
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Circulation: Arrhythmia and Electrophysiology Vol. 14, No. 12 ( 2021-12)
    Details
    In: Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health), Vol. 14, No. 12 ( 2021-12)
    Abstract: Shared decision making (SDM) has been advocated to improve patient care, patient decision acceptance, patient-provider communication, patient motivation, adherence, and patient reported outcomes. Documentation of SDM is endorsed in several society guidelines and is a condition of reimbursement for selected cardiovascular and cardiac arrhythmia procedures. However, many clinicians argue that SDM already occurs with clinical encounter discussions or the process of obtaining informed consent and note the additional imposed workload of using and documenting decision aids without validated tools or evidence that they improve clinical outcomes. In reality, SDM is a process and can be done without decision tools, although the process may be variable. Also, SDM advocates counter that the low-risk process of SDM need not be held to the high bar of demonstrating clinical benefit and that increasing the quality of decision making should be sufficient. Our review leverages a multidisciplinary group of experts in cardiology, cardiac electrophysiology, epidemiology, and SDM, as well as a patient advocate. Our goal is to examine and assess SDM methodology, tools, and available evidence on outcomes in patients with heart rhythm disorders to help determine the value of SDM, assess its possible impact on electrophysiological procedures and cardiac arrhythmia management, better inform regulatory requirements, and identify gaps in knowledge and future needs.
    Type of Medium: Online Resource
    ISSN: 1941-3149 , 1941-3084
    URL: Article
    DOI: 10.1161/CIRCEP.121.007958
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2425487-3
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  • 6
    Online Resource
    Online Resource
    DEVELOPMENT AND VALIDATION OF A RISK SCORE TO PREDICT 1-YEAR MORTALITY IN ICD PATIENTS
    Elsevier BV ; 2011
    In:  Journal of the American College of Cardiology Vol. 57, No. 14 ( 2011-04), p. E105-
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 57, No. 14 ( 2011-04), p. E105-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/S0735-1097(11)60105-8
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 1468327-1
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  • 7
    Online Resource
    Online Resource
    Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease : The PRECISE Randomized Clinical Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Cardiology Vol. 8, No. 10 ( 2023-10-01), p. 904-
    Details
    In: JAMA Cardiology, American Medical Association (AMA), Vol. 8, No. 10 ( 2023-10-01), p. 904-
    Abstract: Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared with stress testing in patients with stable chest pain have informed guidelines but raise questions about overtesting and excess catheterization. Objective To test a modified initial cCTA strategy designed to improve clinical efficiency vs usual testing (UT). Design, Setting, and Participants This was a pragmatic randomized clinical trial enrolling participants from December 3, 2018, to May 18, 2021, with a median of 11.8 months of follow-up. Patients from 65 North American and European sites with stable symptoms of suspected coronary artery disease (CAD) and no prior testing were randomly assigned 1:1 to precision strategy (PS) or UT. Interventions PS incorporated the Prospective Multicenter Imaging Study for the Evaluation of Chest Pain (PROMISE) minimal risk score to quantitatively select minimal-risk participants for deferred testing, assigning all others to cCTA with selective CT-derived fractional flow reserve (FFR-CT). UT included site-selected stress testing or catheterization. Site clinicians determined subsequent care. Main Outcomes and Measures Outcomes were clinical efficiency (invasive catheterization without obstructive CAD) and safety (death or nonfatal myocardial infarction [MI]) combined into a composite primary end point. Secondary end points included safety components of the primary outcome and medication use. Results A total of 2103 participants (mean [SD] age, 58.4 [11.5] years; 1056 male [50.2%]) were included in the study, and 422 [20.1%] were classified as minimal risk. The primary end point occurred in 44 of 1057 participants (4.2%) in the PS group and in 118 of 1046 participants (11.3%) in the UT group (hazard ratio [HR], 0.35; 95% CI, 0.25-0.50). Clinical efficiency was higher with PS, with lower rates of catheterization without obstructive disease (27 [2.6%] ) vs UT participants (107 [10.2%]; HR, 0.24; 95% CI, 0.16-0.36). The safety composite of death/MI was similar (HR, 1.52; 95% CI, 0.73-3.15). Death occurred in 5 individuals (0.5%) in the PS group vs 7 (0.7%) in the UT group (HR, 0.71; 95% CI, 0.23-2.23), and nonfatal MI occurred in 13 individuals (1.2%) in the PS group vs 5 (0.5%) in the UT group (HR, 2.65; 95% CI, 0.96-7.36). Use of lipid-lowering (450 of 900 [50.0%] vs 365 of 873 [41.8%] ) and antiplatelet (321 of 900 [35.7%] vs 237 of 873 [27.1%] ) medications at 1 year was higher in the PS group compared with the UT group (both P   & amp;lt; .001). Conclusions and Relevance An initial diagnostic approach to stable chest pain starting with quantitative risk stratification and deferred testing for minimal-risk patients and cCTA with selective FFR-CT in all others increased clinical efficiency relative to UT at 1 year. Additional randomized clinical trials are needed to verify these findings, including safety. Trial Registration ClinicalTrials.gov Identifier: NCT03702244
    Type of Medium: Online Resource
    ISSN: 2380-6583
    URL: Article
    DOI: 10.1001/jamacardio.2023.2595
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease : A Prespecified Secondary Analysis of the PRECISE Randomized Clinical Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Cardiology Vol. 8, No. 10 ( 2023-10-01), p. 915-
    Details
    In: JAMA Cardiology, American Medical Association (AMA), Vol. 8, No. 10 ( 2023-10-01), p. 915-
    Abstract: Guidelines recommend deferral of testing for symptomatic people with suspected coronary artery disease (CAD) and low pretest probability. To our knowledge, no randomized trial has prospectively evaluated such a strategy. Objective To assess process of care and health outcomes in people identified as minimal risk for CAD when testing is deferred. Design, Setting, and Participants This randomized, pragmatic effectiveness trial included prespecified subgroup analysis of the PRECISE trial at 65 North American and European sites. Participants identified as minimal risk by the validated PROMISE minimal risk score (PMRS) were included. Intervention Randomization to a precision strategy using the PMRS to assign those with minimal risk to deferred testing and others to coronary computed tomography angiography with selective computed tomography-derived fractional flow reserve, or to usual testing (stress testing or catheterization with PMRS masked). Randomization was stratified by PMRS risk. Main Outcome Composite of all-cause death, nonfatal myocardial infarction (MI), or catheterization without obstructive CAD through 12 months. Results Among 2103 participants, 422 were identified as minimal risk (20%) and randomized to deferred testing (n = 214) or usual testing (n = 208). Mean age (SD) was 46 (8.6) years; 304 were women (72%). During follow-up, 138 of those randomized to deferred testing never had testing (64%), whereas 76 had a downstream test (36%) (at median [IQR] 48 [15-78] days) for worsening (30%), uncontrolled (10%), or new symptoms (6%), or changing clinician preference (19%) or participant preference (10%). Results were normal for 96% of these tests. The primary end point occurred in 2 deferred testing (0.9%) and 13 usual testing participants (6.3%) (hazard ratio, 0.15; 95% CI, 0.03-0.66; P  = .01). No death or MI was observed in the deferred testing participants, while 1 noncardiovascular death and 1 MI occurred in the usual testing group. Two participants (0.9%) had catheterizations without obstructive CAD in the deferred testing group and 12 (5.8%) with usual testing ( P  = .02). At baseline, 70% of participants had frequent angina and there was similar reduction of frequent angina to less than 20% at 12 months in both groups. Conclusion and Relevance In symptomatic participants with suspected CAD, identification of minimal risk by the PMRS guided a strategy of initially deferred testing. The strategy was safe with no observed adverse outcome events, fewer catheterizations without obstructive CAD, and similar symptom relief compared with usual testing. Trial Registration ClinicalTrials.gov Identifier: NCT03702244
    Type of Medium: Online Resource
    ISSN: 2380-6583
    URL: Article
    DOI: 10.1001/jamacardio.2023.2614
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    Abstract 183: Safety and Utility Outcomes of Off-label Magnetic Resonance Imaging on Patients With Cardiovascular Implantable Electronic Devices
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Circulation: Cardiovascular Quality and Outcomes Vol. 10, No. suppl_3 ( 2017-03)
    Details
    In: Circulation: Cardiovascular Quality and Outcomes, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. suppl_3 ( 2017-03)
    Abstract: Background: Off-label magnetic resonance imaging (MRI) for patients with cardiac implantable electrical devices (CIEDs) has been limited due to concerns about safety and unclear diagnostic and prognostic utility. Methods: We evaluated all patients with CIEDs not FDA-approved as MRI-conditional who were referred to our clinical protocol for off-label imaging from June 2014 - October 2016. All referrals were screened by radiology and electrophysiology, with peri-MRI programming and monitoring performed by cardiology. Clinical and device characteristics were abstracted from electronic records. The primary safety outcome was the incidence of major adverse events (loss of pacing, inappropriate shock or anti-tachycardia pacing, need for system revision, or death). The primary clinical outcomes were (1) interpretability and (2) utility of MRI, with the latter graded independently by two reviewers according to whether the MRI changed management, prognosis, or guided intervention. Secondary safety outcomes included or minor adverse events (inappropriate pacing, arrhythmias, power on reset events, or discomfort at the generator site), and clinically significant changes in lead parameters or battery life both (1) immediately post-MRI and (2) at six months. Results: A total of 190 MRIs were performed on 123 patients (63.1% men, mean age 70±18.5 years, 37.0% ICDs, 21.8% pacemaker-dependent) predominantly for brain or spinal conditions (Figure). Nearly one quarter (22.7%) were performed for urgent or emergent indications. Major adverse events were rare: no deaths or system revisions; 1 patient with loss of pacing without clinical sequelae (overall rate, 0.5%). Nearly all (98.4%) studies were interpretable, while 74.9% were determined to change management based on pre-specified criteria. Minor adverse events were unusual (overall rate 1.6%): 2 reports of heating at the generator site; 1 patient with an atrial arrhythmia. No clinically significant changes were observed in device parameters acutely after MRI or at 6 months as compared with baseline across all patient and device categories. Conclusions: Off-label MRIs performed under a strict clinical protocol demonstrated reassuring safety outcomes while providing interpretable imaging that frequently influenced clinical care.
    Type of Medium: Online Resource
    ISSN: 1941-7713 , 1941-7705
    URL: Article
    DOI: 10.1161/circoutcomes.10.suppl_3.183
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2453882-6
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  • 10
    Online Resource
    Online Resource
    Patient and Provider Perspectives on Remote Monitoring of Pacemakers and Implantable Cardioverter-Defibrillators
    Elsevier BV ; 2021
    In:  The American Journal of Cardiology Vol. 149 ( 2021-06), p. 42-46
    Details
    In: The American Journal of Cardiology, Elsevier BV, Vol. 149 ( 2021-06), p. 42-46
    Type of Medium: Online Resource
    ISSN: 0002-9149
    URL: Article
    DOI: 10.1016/j.amjcard.2021.03.023
    RVK:
    XA 18500
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2019595-3
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