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  • 1
    In: Publications of the Astronomical Society of the Pacific, IOP Publishing, Vol. 135, No. 1048 ( 2023-06-01), p. 068001-
    Abstract: Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.
    Type of Medium: Online Resource
    ISSN: 0004-6280 , 1538-3873
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2003100-2
    detail.hit.zdb_id: 2207655-4
    SSG: 16,12
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  • 2
    In: Journal of Atmospheric and Oceanic Technology, American Meteorological Society, Vol. 27, No. 10 ( 2010-10-01), p. 1652-1664
    Abstract: A method of estimating dissipation rates from a vertically pointing Doppler lidar with high temporal and spatial resolution has been evaluated by comparison with independent measurements derived from a balloon-borne sonic anemometer. This method utilizes the variance of the mean Doppler velocity from a number of sequential samples and requires an estimate of the horizontal wind speed. The noise contribution to the variance can be estimated from the observed signal-to-noise ratio and removed where appropriate. The relative size of the noise variance to the observed variance provides a measure of the confidence in the retrieval. Comparison with in situ dissipation rates derived from the balloon-borne sonic anemometer reveal that this particular Doppler lidar is capable of retrieving dissipation rates over a range of at least three orders of magnitude. This method is most suitable for retrieval of dissipation rates within the convective well-mixed boundary layer where the scales of motion that the Doppler lidar probes remain well within the inertial subrange. Caution must be applied when estimating dissipation rates in more quiescent conditions. For the particular Doppler lidar described here, the selection of suitably short integration times will permit this method to be applicable in such situations but at the expense of accuracy in the Doppler velocity estimates. The two case studies presented here suggest that, with profiles every 4 s, reliable estimates of ε can be derived to within at least an order of magnitude throughout almost all of the lowest 2 km and, in the convective boundary layer, to within 50%. Increasing the integration time for individual profiles to 30 s can improve the accuracy substantially but potentially confines retrievals to within the convective boundary layer. Therefore, optimization of certain instrument parameters may be required for specific implementations.
    Type of Medium: Online Resource
    ISSN: 1520-0426 , 0739-0572
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2010
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  • 3
    In: Annals of Neurology, Wiley, Vol. 83, No. 6 ( 2018-06), p. 1105-1124
    Abstract: Comprehensive clinical characterization of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. Methods Using massively parallel sequencing we identified 30 patients from 27 families with 2 pathogenic nonsense, frameshift and/or splice site TTN mutations in trans . We then undertook a detailed analysis of the clinical, histopathological and imaging features of these patients. Results All patients had prenatal or early onset hypotonia and/or congenital contractures. None had ophthalmoplegia. Scoliosis and respiratory insufficiency typically developed early and progressed rapidly, whereas limb weakness was often slowly progressive, and usually did not prevent independent walking. Cardiac involvement was present in 46% of patients. Relatives of 2 patients had dilated cardiomyopathy. Creatine kinase levels were normal to moderately elevated. Increased fiber size variation, internalized nuclei and cores were common histopathological abnormalities. Cap‐like regions, whorled or ring fibers, and mitochondrial accumulations were also observed. Muscle magnetic resonance imaging showed gluteal, hamstring and calf muscle involvement. Western blot analysis showed a near‐normal sized titin protein in all samples. The presence of 2 mutations predicted to impact both N2BA and N2B cardiac isoforms appeared to be associated with greatest risk of cardiac involvement. One‐third of patients had 1 mutation predicted to impact exons present in fetal skeletal muscle, but not included within the mature skeletal muscle isoform transcript. This strongly suggests developmental isoforms are involved in the pathogenesis of this congenital/early onset disorder. Interpretation This detailed clinical reference dataset will greatly facilitate diagnostic confirmation and management of patients, and has provided important insights into disease pathogenesis. Ann Neurol 2018;83:1105–1124
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 4
    In: FEBS Letters, Wiley, Vol. 549, No. 1-3 ( 2003-08-14), p. 26-30
    Abstract: We functionally identified the last remaining step in the plant polyamine biosynthetic pathway by expressing an Arabidopsis thaliana agmatine iminohydrolase cDNA in yeast. Inspection of the whole pathway suggests that the arginine decarboxylase, agmatine iminohydrolase, N ‐carbamoylputrescine amidohydrolase route to putrescine in plants was inherited from the cyanobacterial ancestor of the chloroplast. However, the rest of the pathway including ornithine decarboxylase and spermidine synthase was probably inherited from bacterial genes present in the original host cell, common ancestor of plants and animals, that acquired the cyanobacterial endosymbiont. An exception is S ‐adenosylmethionine decarboxylase, which may represent a eukaryote‐specific enzyme form.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2003
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  • 5
    Online Resource
    Online Resource
    American Meteorological Society ; 2005
    In:  Journal of Applied Meteorology Vol. 44, No. 1 ( 2005-01-01), p. 14-27
    In: Journal of Applied Meteorology, American Meteorological Society, Vol. 44, No. 1 ( 2005-01-01), p. 14-27
    Abstract: Stratocumulus is one of the most common cloud types globally, with a profound effect on the earth’s radiation budget, and the drizzle process is fundamental in understanding the evolution of these boundary layer clouds. In this paper a combination of 94-GHz Doppler radar and backscatter lidar is used to investigate the microphysical properties of drizzle falling below the base of stratocumulus clouds. The ratio of the radar to lidar backscatter power is proportional to the fourth power of mean size, and so potentially it can provide an accurate size estimate. Information about the shape of the drop size distribution is then inferred from the Doppler spectral width. The algorithm estimates vertical profiles of drizzle parameters such as liquid water content, liquid water flux, and vertical air velocity, assuming that the drizzle size spectrum may be represented by a gamma distribution. The depletion time scale of cloud liquid water through the drizzle process can be estimated when the liquid water path of the cloud is available from microwave radiometers, and observations suggest that this time scale varies from a few days in light drizzle to a few hours in strong drizzle events. Radar and lidar observations from Chilbolton (in southern England) and aircraft size spectra taken during the Atlantic Stratocumulus Transition Experiment have both been used to derive the following power-law relationship between liquid water flux (LWF) (g m−2 s−1) and radar reflectivity (Z) (mm6 m−3): LWF = 0.0093Z0.69. This relation is valid for frequencies up to 94 GHz and therefore would allow a forthcoming spaceborne radar to measure liquid water flux around the globe to within a factor of 2 for values of Z above −20 dBZ.
    Type of Medium: Online Resource
    ISSN: 1520-0450 , 0894-8763
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2005
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  • 6
    In: Journal of Atmospheric and Oceanic Technology, American Meteorological Society, Vol. 23, No. 2 ( 2006-02-01), p. 211-227
    Abstract: The combination of radar and lidar in space offers the unique potential to retrieve vertical profiles of ice water content and particle size globally, and two algorithms developed recently claim to have overcome the principal difficulty with this approach—that of correcting the lidar signal for extinction. In this paper “blind tests” of these algorithms are carried out, using realistic 94-GHz radar and 355-nm lidar backscatter profiles simulated from aircraft-measured size spectra, and including the effects of molecular scattering, multiple scattering, and instrument noise. Radiation calculations are performed on the true and retrieved microphysical profiles to estimate the accuracy with which radiative flux profiles could be inferred remotely. It is found that the visible extinction profile can be retrieved independent of assumptions on the nature of the size distribution, the habit of the particles, the mean extinction-to-backscatter ratio, or errors in instrument calibration. Local errors in retrieved extinction can occur in proportion to local fluctuations in the extinction-to-backscatter ratio, but down to 400 m above the height of the lowest lidar return, optical depth is typically retrieved to better than 0.2. Retrieval uncertainties are greater at the far end of the profile, and errors in total optical depth can exceed 1, which changes the shortwave radiative effect of the cloud by around 20%. Longwave fluxes are much less sensitive to errors in total optical depth, and may generally be calculated to better than 2 W m−2 throughout the profile. It is important for retrieval algorithms to account for the effects of lidar multiple scattering, because if this is neglected, then optical depth is underestimated by approximately 35%, resulting in cloud radiative effects being underestimated by around 30% in the shortwave and 15% in the longwave. Unlike the extinction coefficient, the inferred ice water content and particle size can vary by 30%, depending on the assumed mass–size relationship (a problem common to all remote retrieval algorithms). However, radiative fluxes are almost completely determined by the extinction profile, and if this is correct, then errors in these other parameters have only a small effect in the shortwave (around 6%, compared to that of clear sky) and a negligible effect in the longwave.
    Type of Medium: Online Resource
    ISSN: 1520-0426 , 0739-0572
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2006
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  • 7
    Online Resource
    Online Resource
    American Meteorological Society ; 2004
    In:  Journal of Atmospheric and Oceanic Technology Vol. 21, No. 5 ( 2004-05), p. 777-786
    In: Journal of Atmospheric and Oceanic Technology, American Meteorological Society, Vol. 21, No. 5 ( 2004-05), p. 777-786
    Type of Medium: Online Resource
    ISSN: 0739-0572 , 1520-0426
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2004
    detail.hit.zdb_id: 2021720-1
    detail.hit.zdb_id: 48441-6
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2009
    In:  Quarterly Journal of the Royal Meteorological Society Vol. 135, No. 643 ( 2009-07), p. 1494-1511
    In: Quarterly Journal of the Royal Meteorological Society, Wiley, Vol. 135, No. 643 ( 2009-07), p. 1494-1511
    Type of Medium: Online Resource
    ISSN: 0035-9009
    RVK:
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2009
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    detail.hit.zdb_id: 2089168-4
    SSG: 14
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  • 9
    In: Journal of Applied Meteorology and Climatology, American Meteorological Society, Vol. 49, No. 9 ( 2010-09-01), p. 1971-1991
    Abstract: The ability of four operational weather forecast models [ECMWF, Action de Recherche Petite Echelle Grande Echelle model (ARPEGE), Regional Atmospheric Climate Model (RACMO), and Met Office] to generate a cloud at the right location and time (the cloud frequency of occurrence) is assessed in the present paper using a two-year time series of observations collected by profiling ground-based active remote sensors (cloud radar and lidar) located at three different sites in western Europe (Cabauw, Netherlands; Chilbolton, United Kingdom; and Palaiseau, France). Particular attention is given to potential biases that may arise from instrumentation differences (especially sensitivity) from one site to another and intermittent sampling. In a second step the statistical properties of the cloud variables involved in most advanced cloud schemes of numerical weather forecast models (ice water content and cloud fraction) are characterized and compared with their counterparts in the models. The two years of observations are first considered as a whole in order to evaluate the accuracy of the statistical representation of the cloud variables in each model. It is shown that all models tend to produce too many high-level clouds, with too-high cloud fraction and ice water content. The midlevel and low-level cloud occurrence is also generally overestimated, with too-low cloud fraction but a correct ice water content. The dataset is then divided into seasons to evaluate the potential of the models to generate different cloud situations in response to different large-scale forcings. Strong variations in cloud occurrence are found in the observations from one season to the same season the following year as well as in the seasonal cycle. Overall, the model biases observed using the whole dataset are still found at seasonal scale, but the models generally manage to well reproduce the observed seasonal variations in cloud occurrence. Overall, models do not generate the same cloud fraction distributions and these distributions do not agree with the observations. Another general conclusion is that the use of continuous ground-based radar and lidar observations is definitely a powerful tool for evaluating model cloud schemes and for a responsive assessment of the benefit achieved by changing or tuning a model cloud parameterization.
    Type of Medium: Online Resource
    ISSN: 1558-8432 , 1558-8424
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2010
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2003
    In:  Journal of Atmospheric and Oceanic Technology Vol. 20, No. 4 ( 2003-04), p. 572-580
    In: Journal of Atmospheric and Oceanic Technology, American Meteorological Society, Vol. 20, No. 4 ( 2003-04), p. 572-580
    Type of Medium: Online Resource
    ISSN: 0739-0572 , 1520-0426
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2003
    detail.hit.zdb_id: 2021720-1
    detail.hit.zdb_id: 48441-6
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