In:
Pediatric Obesity, Wiley, Vol. 9, No. 6 ( 2014-12), p. 463-470
Abstract:
The expression of specific genes in peripheral blood cells (PBCs) may be used as biomarkers of the metabolic status. High levels of expression of CPT1A, SLC27A2, INSR, LEPR, FASN and PPARα in PBCs are indicative of a lower risk for the insulin resistant or dyslipidaemic state associated with obesity in children. Breastfeeding seems to confer protective effects against obesity and its related metabolic problems. What this study adds Children who had been breastfed showed higher expression levels of SLC27A2, FASN, PPARα and INSR in PBCs compared with formula‐fed subjects. The relationship of the PBC transcript levels of SLC27A2, INSR, FASN and PPARα with insulin resistance and dyslipidaemia may be dependent on the type of infant feeding (breast vs. formula). The transcript levels of the mentioned biomarkers could be useful to distinguish the formula‐fed children who are at higher risk of metabolic alterations. Background Blood‐cell transcripts have showed to be good biomarkers of metabolic alterations and their use in early detection and prevention of future disorders is promising. Objective This study aimed to examine the relation between previously proposed transcriptional biomarkers of metabolic health ( SLC27A2 , CPT1A , FASN , PPAR α , INSR , LEPR ) in peripheral blood cells and the type of infant feeding in a subset of children from the IDEFICS (Identification and Prevention of Dietary‐ and Lifestyle‐Induced Health Effects in Children and Infants) cohort. Subjects A total of 237 children aged 2–9 years from eight E uropean countries were studied. Results Breastfed children showed higher expression levels of SLC27A2 , FASN , PPAR α and INSR , and lower risk of being overweight and of having high plasma triglyceride levels vs. formula‐fed children. Besides, overweight formula‐fed children presented higher HOMA ‐index than overweight breastfed children (1.90 vs. 1.62); however, this negative effect was absent in formula‐fed children with high expression of SLC27A2 . Moreover, formula‐fed children with low expression of SLC27A2 , FASN , PPAR α and INSR presented higher triglyceride levels than subjects with high expression of these genes (77.7 mg dL −1 vs. 44.8 mg dL −1 ). This difference was absent in breastfed children. Conclusions Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2 , FASN , PPAR α and INSR in blood cells. These biomarkers may also serve to discriminate the formula‐fed children that are at higher risk of metabolic alterations.
Type of Medium:
Online Resource
ISSN:
2047-6302
,
2047-6310
DOI:
10.1111/ijpo.2014.9.issue-6
DOI:
10.1111/j.2047-6310.2013.00204.x
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2648531-X
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