In:
Brain Sciences, MDPI AG, Vol. 12, No. 6 ( 2022-06-07), p. 747-
Abstract:
Objectives: Patients with occlusal disharmony (OD) may be susceptible to depression. The hypothalamus–pituitary–adrenal axis, 5-HT and 5HT2AR in the prefrontal cortex (PFC), amygdala, and hippocampus are involved in the modulation of emotion and depression. This study investigated whether OD affects the HPA axis and 5-HT system and, subsequently, produces depression-like behaviors in rats. Materials and methods: OD was produced by removing 0.5 and 0.25 mm of hard tissue from the cusps of the maxillary molars in randomly selected sides of Sprague–Dawley rats. CUS involved exposure to 2 different stressors per day for 35 days. OD-, CUS-, and OD + CUS-treated groups and an untreated control group were compared in terms of behavior, endocrine status and brain histology. Results: There were significant differences among the four groups in the behavior tests (p 〈 0.05), especially in the sucrose preference test, where there was a significant decrease in the OD group compared to the control group. ACTH and CORT concentrations were significantly higher in the OD + CUS group than the control group (p 〈 0.05). Expression of GR and 5-HT2AR in the PFC, amygdala and hippocampal CA1 was significantly higher in the OD, CUS and OD + CUS groups than the control group (p 〈 0.05). Conclusion: OD promotes depression-like behaviors through peripheral and central pathways via the HPA axis, GR and 5-HT system.
Type of Medium:
Online Resource
ISSN:
2076-3425
DOI:
10.3390/brainsci12060747
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2651993-8
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