In:
Angewandte Chemie, Wiley, Vol. 130, No. 19 ( 2018-05-04), p. 5590-5594
Abstract:
We have developed a photoinduced copper‐catalyzed alkylation of terminal alkynes with primary, secondary, or tertiary alkyl iodides as electrophiles. The reaction has a broad substrate scope and can be successfully performed in the presence of ester, nitrile, aryl halide, ketone, sulfonamide, epoxide, alcohol, and amide functional groups. The alkylation is promoted by blue light ( λ ≈450 nm) and proceeds at room temperature in the absence of any additional metal catalysts. The use of a terpyridine ligand is essential for the success of the reaction and is shown to prevent photoinduced copper‐catalyzed polymerization of the starting materials.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.19
DOI:
10.1002/ange.201801085
Language:
English
Publisher:
Wiley
Publication Date:
2018
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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