In:
International Journal of Cancer, Wiley, Vol. 147, No. 10 ( 2020-11-15), p. 2801-2810
Abstract:
What's new? Lynch syndrome (LS) is the most common hereditary colorectal cancer. While these cancers usually show microsatellite instability (MSI), most MSI tumors are sporadic. Here, the authors evaluated the usefulness of testing for BRAF mutations as a way to distinguish LS cancers from sporadic cases. They found that the frequency of tumors carrying BRAF mutations in LS patients under age 50 is very similar to the frequency of those mutations in MSI cancers from that age group, suggesting that there's substantial overlap between the two groups. Thus, BRAF mutation status should not be used to exclude LS in patients under 50.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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