GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
    Springer Science and Business Media LLC ; 2022
    In:  Human Genetics Vol. 141, No. 1 ( 2022-01), p. 147-173
    Details
    In: Human Genetics, Springer Science and Business Media LLC, Vol. 141, No. 1 ( 2022-01), p. 147-173
    Abstract: The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.
    Type of Medium: Online Resource
    ISSN: 0340-6717 , 1432-1203
    URL: Article
    DOI: 10.1007/s00439-021-02397-7
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1459188-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk
    American Diabetes Association ; 2018
    In:  Diabetes Care Vol. 41, No. 9 ( 2018-09-01), p. 1887-1894
    Details
    In: Diabetes Care, American Diabetes Association, Vol. 41, No. 9 ( 2018-09-01), p. 1887-1894
    Abstract: We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS We studied the 1,244 TrialNet Pathway to Prevention study participants (T1D patients’ relatives without diabetes and with one or more positive autoantibodies) who were genotyped with Illumina ImmunoChip (median [range] age at initial autoantibody determination 11.1 years [1.2–51.8], 48% male, 80.5% non-Hispanic white, median follow-up 5.4 years). Of 291 participants with a single positive autoantibody at screening, 157 converted to multiple autoantibody positivity and 55 developed diabetes. Of 953 participants with multiple positive autoantibodies at screening, 419 developed diabetes. We calculated the T1D GRS from 30 T1D-associated single nucleotide polymorphisms. We used multivariable Cox regression models, time-dependent receiver operating characteristic curves, and area under the curve (AUC) measures to evaluate prognostic utility of T1D GRS, age, sex, Diabetes Prevention Trial–Type 1 (DPT-1) Risk Score, positive autoantibody number or type, HLA DR3/DR4-DQ8 status, and race/ethnicity. We used recursive partitioning analyses to identify cut points in continuous variables. RESULTS Higher T1D GRS significantly increased the rate of progression to T1D adjusting for DPT-1 Risk Score, age, number of positive autoantibodies, sex, and ethnicity (hazard ratio [HR] 1.29 for a 0.05 increase, 95% CI 1.06–1.6; P = 0.011). Progression to T1D was best predicted by a combined model with GRS, number of positive autoantibodies, DPT-1 Risk Score, and age (7-year time-integrated AUC = 0.79, 5-year AUC = 0.73). Higher GRS was significantly associated with increased progression rate from single to multiple positive autoantibodies after adjusting for age, autoantibody type, ethnicity, and sex (HR 2.27 for GRS & gt;0.295, 95% CI 1.47–3.51; P = 0.0002). CONCLUSIONS The T1D GRS independently predicts progression to T1D and improves prediction along T1D stages in autoantibody-positive relatives.
    Type of Medium: Online Resource
    ISSN: 0149-5992 , 1935-5548
    URL: Article
    DOI: 10.2337/dc18-0087
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2018
    detail.hit.zdb_id: 1490520-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Pattern and origin of stepped-bed morphology in high-gradient streams, Western Cascades, Oregon
    Geological Society of America ; 1990
    In:  Geological Society of America Bulletin Vol. 102, No. 3 ( 1990-3), p. 340-352
    Details
    In: Geological Society of America Bulletin, Geological Society of America, Vol. 102, No. 3 ( 1990-3), p. 340-352
    Type of Medium: Online Resource
    ISSN: 0016-7606
    URL: Article
    DOI: 10.1130/0016-7606(1990)102〈0340:PAOOSB〉2.3.CO;2
    Language: Unknown
    Publisher: Geological Society of America
    Publication Date: 1990
    detail.hit.zdb_id: 2028776-8
    detail.hit.zdb_id: 2008165-0
    detail.hit.zdb_id: 449720-X
    detail.hit.zdb_id: 1351-1
    SSG: 13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The frontier beneath our feet
    American Geophysical Union (AGU) ; 2017
    In:  Water Resources Research Vol. 53, No. 4 ( 2017-04), p. 2605-2609
    Details
    In: Water Resources Research, American Geophysical Union (AGU), Vol. 53, No. 4 ( 2017-04), p. 2605-2609
    Abstract: The critical zone is a new and exciting frontier in earth and biological sciences Critical zone science is transforming our understanding of linkages among vegetation, soils, bedrock, and the movement of water Critical zone science contributes to understanding key social problems: forest health, soil productivity, and effects of natural disasters
    Type of Medium: Online Resource
    ISSN: 0043-1397 , 1944-7973
    URL: Issue
    URL: Article
    DOI: 10.1002/wrcr.v53.4
    DOI: 10.1002/2017WR020835
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2017
    detail.hit.zdb_id: 2029553-4
    detail.hit.zdb_id: 5564-5
    SSG: 13
    SSG: 14
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Initial Fluvial Response to the Removal of Oregon's Marmot Dam
    American Geophysical Union (AGU) ; 2008
    In:  Eos, Transactions American Geophysical Union Vol. 89, No. 27 ( 2008-07), p. 241-242
    Details
    In: Eos, Transactions American Geophysical Union, American Geophysical Union (AGU), Vol. 89, No. 27 ( 2008-07), p. 241-242
    Abstract: A temporary, 14‐meter‐high earthen cofferdam standing in place of Marmot Dam was breached on 19 October 2007, allowing the 80‐ kilometer‐long Sandy River to flow freely from Mount Hood, Oreg., to the Columbia River for the first time in nearly 100 years. Marmot Dam is one of the largest dams in the western United States (in terms of height and volume of stored sediment) to have been removed in the past 40 years, and its removal exposed approximately 730,000 cubic meters of stored sand and gravel to erosion and transport by the newly energetic mountain river. At the time, its breach represented the greatest release of sediment from any U.S. dam removal. (The March 2008 breaching of Montana's Milltown Dam exposed about 5–10 times as much sediment to potential erosion.)
    Type of Medium: Online Resource
    ISSN: 0096-3941 , 2324-9250
    URL: Article
    DOI: 10.1029/2008EO270001
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2008
    detail.hit.zdb_id: 24845-9
    detail.hit.zdb_id: 2118760-5
    detail.hit.zdb_id: 240154-X
    SSG: 16,13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    SEDIMENT TRANSPORT AND CHANNEL MORPHOLOGY OF SMALL, FORESTED STREAMS
    Wiley ; 2005
    In:  Journal of the American Water Resources Association Vol. 41, No. 4 ( 2005-08), p. 853-876
    Details
    In: Journal of the American Water Resources Association, Wiley, Vol. 41, No. 4 ( 2005-08), p. 853-876
    Type of Medium: Online Resource
    ISSN: 1093-474X , 1752-1688
    URL: Issue
    URL: Article
    DOI: 10.1111/jawr.2005.41.issue-4
    DOI: 10.1111/j.1752-1688.2005.tb03774.x
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2090051-X
    SSG: 14
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Novel dimensionless index for physically based assessment of thermal refugia characterizes off‐channel habitat on gravel bed river
    Wiley ; 2023
    In:  JAWRA Journal of the American Water Resources Association Vol. 59, No. 4 ( 2023-08), p. 615-634
    Details
    In: JAWRA Journal of the American Water Resources Association, Wiley, Vol. 59, No. 4 ( 2023-08), p. 615-634
    Abstract: In the Willamette River, OR, main channel temperatures can be too warm for cold water fishes, causing fish to concentrate in secondary channel features that provide thermal refugia. However, temperature regimes vary among and within features. Improved understanding of physical processes controlling thermal regimes is needed. This study developed a dimensionless index for assessment of thermal refugia on the upper Willamette River. The novel hyporheic insolation (HIN) index uses minimal field measurements to predict thermal refugia resulting from buffering. Continuous water temperature measurements at one side channel, eight alcoves, and six beaver ponds provided data to ground truth calculated predictions. Water temperature records were first used to characterize stratification at sites. Calculation of the Richardson number, an index of stability, showed two well‐mixed sites and 13 stratified sites. At stratified sites, calculated values characterized the ratio of cooling flux from hyporheic discharge to heat flux from incoming solar radiation. As increased, measured temperatures at sites decreased. Despite overall scatter, a logarithmic fit to bin‐averaged values showed R 2  = 0.91. Calculations suggest that secondary channel features characterized by stratification and cool hyporheic discharge can provide thermal refugia. Accordingly, the HIN index may serve as a practical tool grounded in physical processes governing temperature across a floodplain.
    Type of Medium: Online Resource
    ISSN: 1093-474X , 1752-1688
    URL: Issue
    URL: Article
    DOI: 10.1111/jawr.v59.4
    DOI: 10.1111/1752-1688.13096
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2090051-X
    SSG: 14
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Autopsy of a reservoir: Facies architecture in a multidam system, Elwha River, Washington, USA
    Geological Society of America ; 2019
    In:  GSA Bulletin Vol. 131, No. 11-12 ( 2019-11-01), p. 1794-1822
    Details
    In: GSA Bulletin, Geological Society of America, Vol. 131, No. 11-12 ( 2019-11-01), p. 1794-1822
    Abstract: The 2011–2014 removal of two large dams on the Elwha River, Washington State, the largest dam removal yet completed globally, created extensive cutbank exposures of reservoir sediments, allowing the first characterization of the facies architecture of sediments through direct observation in reservoirs worldwide and providing an unparalleled opportunity to assess the relationship between environmental influences, such as changes in sediment supply, and their expression in the stratigraphic record. Using a combination of facies description from observation of 49 measured sections and 〉 100 exposures and analysis of digital elevation models and historic aerial photographs, we delineated the characteristic depositional zones of each reservoir and mapped the evolution of the subaerial delta over the life span of the reservoir. Former Lake Mills, the younger, upstream reservoir, was characterized by a tripartite, subaerial Gilbert-style delta that prograded 〉 1 km into the main reservoir from 1927 to 2011. Sediments were composed of coarse-grained topset beds, steeply dipping foreset beds, and a fine-grained, gently dipping prodelta. While individual event horizons were discernible in fine-grained sediments of former Lake Mills, their number and spacing did not correspond to known drawdown or flood events. Former Lake Aldwell, impounded from 1913 to 2011, was initially defined by the rapid progradation of a Gilbert-style, subaerial delta prior to the upstream completion of Glines Canyon Dam. However, the 1927 closure of Glines Canyon Dam upstream caused the delta to evolve to a fine-grained, mouth-bar–type delta indicative of low, finer-grained sediment. This evolution, combined with a previously unrecognized landslide deposit into the upper delta plain, suggests that understanding the exogenic influences on reservoir sedimentation is critical to interpretation and prediction of the sedimentation within individual systems.
    Type of Medium: Online Resource
    ISSN: 0016-7606 , 1943-2674
    URL: Article
    URL: Article
    DOI: 10.1130/B31959.1
    DOI: 10.1130/2018204
    Language: English
    Publisher: Geological Society of America
    Publication Date: 2019
    detail.hit.zdb_id: 2028776-8
    detail.hit.zdb_id: 2008165-0
    detail.hit.zdb_id: 449720-X
    detail.hit.zdb_id: 1351-1
    SSG: 13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Downstream Effects of Timber Harvesting on Channel Morphology in Elk River Basin, Oregon
    Wiley ; 1991
    In:  Journal of Environmental Quality Vol. 20, No. 1 ( 1991-01), p. 60-72
    Details
    In: Journal of Environmental Quality, Wiley, Vol. 20, No. 1 ( 1991-01), p. 60-72
    Abstract: Downstream effects, a type of cumulative watershed effect, were identified using changes in the width and distribution of open riparian canopies measured from aerial photography taken between 1956 and 1979 in Elk River basin, southwest Oregon. Open canopies appear on aerial photographs of densely forested basins as unvegetated areas bordering stream channels. Opening occurs when large disturbances, such as landslides, debris flows, large floods, and excessive sedimentation, disrupt the vegetation in the riparian corridor. Downstream changes in channel morphology, inferred by the changing pattern of open reaches were linked to upslope forestry activities; a causal link was assumed where: (i) open reaches extended continuously downstream from clearcuts and roads or (ii) the timing and pattern of opening downstream varied in direct relation to the intensity of upslope forestry activities. Open riparian canopies were observed in first‐ through fifth‐order channels, though only 11% of open reaches in low‐order channels were spatially connected to open reaches in higher order channels. Open reaches on low‐order tributaries were attributed to landslides and surface erosion generated from clearcuts and roads; the total length of open reaches in low‐order channels increased 30‐fold during the study period. Open reaches occurred on higher‐order channels throughout the study period but did not increase in size or change location in relation to upslope harvest activities. Instead, open canopies were restricted mainly to wide and low gradient channel reaches, which comprised approximately one‐third of the length of higher‐order channels. Limited downstream change in riparian canopies associated with upslope forestry activity during the study period, which included a 100‐yr storm, was attributed to three physical factors: (i) lack of debris flows in most parts of the basin; (ii) channels constrained by competent hillslopes limiting the potential for opening; and (iii) low harvest levels over much of the basin at the time of the 100‐yr storm. While air photo interpretation proved useful in deciphering the gross disturbance history of the basin and in distinguishing the general processes which generate downstream effects, sedimentation processes that do not disturb the riparian canopy may also be active in Elk River basin but were not detected due to the coarseness of the techniques used.
    Type of Medium: Online Resource
    ISSN: 0047-2425 , 1537-2537
    URL: Article
    DOI: 10.2134/jeq1991.00472425002000010011x
    Language: English
    Publisher: Wiley
    Publication Date: 1991
    detail.hit.zdb_id: 120525-0
    detail.hit.zdb_id: 2050469-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Effects of climate change on hydrology and water resources in the Blue Mountains, Oregon, USA
    Elsevier BV ; 2018
    In:  Climate Services Vol. 10 ( 2018-04), p. 9-19
    Details
    In: Climate Services, Elsevier BV, Vol. 10 ( 2018-04), p. 9-19
    Type of Medium: Online Resource
    ISSN: 2405-8807
    URL: Article
    DOI: 10.1016/j.cliser.2018.03.001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2858351-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...