In:
Cancer Research, Statistics, and Treatment, Medknow, Vol. 7, No. Suppl 1 ( 2024), p. S17-S21
Abstract:
In early hypopharyngeal cancer, definitive radiotherapy (RT) is the preferred modality of treatment. The surgical treatment options are transoral laser microsurgery with selective neck dissection or a partial laryngopharyngectomy plus neck dissection. In locally advanced disease, concurrent chemoradiotherapy (CTRT) is the treatment of choice. Neoadjuvant chemotherapy (NACT) is also a recommended treatment option followed by radical RT/CTRT or surgery followed by adjuvant RT/CTRT, depending on the response. Some patients with locally advanced disease may require total or near total laryngectomy/total or partial pharyngectomy with appropriate neck dissection. Adding targeted therapies like nimotuzumab to cisplatin-based CTRT in locally advanced head-and-neck squamous cell carcinoma improves progression-free survival, locoregional control, and disease-free survival without negatively impacting the quality of life.
Type of Medium:
Online Resource
ISSN:
2590-3233
,
2590-3225
DOI:
10.4103/crst.crst_121_23
Language:
English
Publisher:
Medknow
Publication Date:
2024
detail.hit.zdb_id:
2987023-9
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