In:
Annual Review of Microbiology, Annual Reviews, Vol. 76, No. 1 ( 2022-09-08), p. 113-134
Kurzfassung:
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for parasite development, transmission, and survival. Most research has focused on Plasmodium development in the vertebrate, which causes disease; however, knowledge of malaria parasite development in the mosquito (the sexual and transmission stages) is now rapidly accumulating, gathered largely through investigation of the rodent malaria model, with Plasmodium berghei. In this review, we discuss the seminal genome-wide screens that have uncovered key regulators of cell proliferation, invasion, and transmission during Plasmodium sexual development. Our focus is on the roles of transcription factors, reversible protein phosphorylation, and molecular motors. We also emphasize the still-unanswered important questions around key pathways in cell division during the vector transmission stages and how they may be targeted in future studies.
Materialart:
Online-Ressource
ISSN:
0066-4227
,
1545-3251
DOI:
10.1146/micro.2022.76.issue-1
DOI:
10.1146/annurev-micro-041320-010046
Sprache:
Englisch
Verlag:
Annual Reviews
Publikationsdatum:
2022
ZDB Id:
1470471-7
SSG:
12
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