In:
Pharmacopsychiatry, Georg Thieme Verlag KG, Vol. 56, No. 01 ( 2023-01), p. 32-39
Abstract:
Introduction Children and adolescents with multiple disabilities and
mental disorders (CAMD) are frequently treated with antipsychotic drugs. However, CAMD are particularly susceptible to serious adverse drug reactions
(sADRs). This retrospective study examined the frequency of sADRs to antipsychotics in CAMD. Further, the potential preventability of these sADRs
through therapeutic drug monitoring (TDM) and the potential socio-economic benefits of TDM were explored. Methods Routine clinical data of all patients treated at a specialized
psychiatric clinic for CAMD between January 2017 and December 2018 were retrospectively examined. Data on the occurrence of sADRs (definition according
to the European Medicines Agency), their causality with antipsychotics, as well as their preventability (Schumock criteria) were extracted from patient files.
The prolongation of the hospital stay due to sADRs was calculated, and the cost savings were estimated if TDM had been applied. The data were based on a
subsample of the KiDSafe project, supported by the Innovation Fund of the Joint Federal Committee, grant number 01NVF16021. Results One hundred two CAMD who were administered at least one
antipsychotic drug during inpatient treatment were identified. Of these patients, 22 (21.6%) sADRs with a possible causal relationship with the
antipsychotic treatment were documented. Eleven sADRs (50%) could potentially have been prevented through TDM. Mitigating sADRs through TDM likely
would have prevented prolonged hospital stays and thus conferred considerable savings for health insurance companies. Discussion The routine implementation of TDM is urgently recommended for
antipsychotic treatment in CAMD to increase drug therapy safety.
Type of Medium:
Online Resource
ISSN:
0176-3679
,
1439-0795
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
2041961-2
SSG:
15,3
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