In:
The International Journal of Artificial Organs, SAGE Publications, Vol. 42, No. 10 ( 2019-10), p. 586-594
Abstract:
One of the main challenges of the interface-tissue engineering is the regeneration of diseased or damaged interfacial native tissues that are heterogeneous both in composition and in structure. In order to achieve this objective, innovative fabrication techniques have to be investigated. This work describes the design, fabrication, and validation of a novel mixing system to be integrated into a double-extruder bioprinter, based on an ultrasonic probe included into a mixing chamber. To validate the quality and the influence of mixing time, different nanohydroxyapatite–gelatin samples were printed. Mechanical characterization, micro-computed tomography, and thermogravimetric analysis were carried out. Samples obtained from three-dimensional bioprinting using the mixing chamber were compared to samples obtained by deposition of the same final solution obtained by manually operated ultrasound probe, showing no statistical differences. Results obtained from samples characterization allow to consider the proposed mixing system as a promising tool for the fabrication of graduated structures which are increasingly being used in interface-tissue engineering.
Type of Medium:
Online Resource
ISSN:
0391-3988
,
1724-6040
DOI:
10.1177/0391398819852960
Language:
English
Publisher:
SAGE Publications
Publication Date:
2019
detail.hit.zdb_id:
1474999-3
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