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  • 1
    Online Resource
    Online Resource
    A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Big Data Vol. 9, No. 1 ( 2022-10-13)
    Details
    In: Journal of Big Data, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2022-10-13)
    Abstract: Beyond detecting brain lesions or tumors, comparatively little success has been attained in identifying brain disorders such as Alzheimer’s disease (AD), based on magnetic resonance imaging (MRI). Many machine learning algorithms to detect AD have been trained using limited training data, meaning they often generalize poorly when applied to scans from previously unseen scanners/populations. Therefore, we built a practical brain MRI-based AD diagnostic classifier using deep learning/transfer learning on a dataset of unprecedented size and diversity. A retrospective MRI dataset pooled from more than 217 sites/scanners constituted one of the largest brain MRI samples to date (85,721 scans from 50,876 participants) between January 2017 and August 2021. Next, a state-of-the-art deep convolutional neural network, Inception-ResNet-V2, was built as a sex classifier with high generalization capability. The sex classifier achieved 94.9% accuracy and served as a base model in transfer learning for the objective diagnosis of AD. After transfer learning, the model fine-tuned for AD classification achieved 90.9% accuracy in leave-sites-out cross-validation on the Alzheimer’s Disease Neuroimaging Initiative (ADNI, 6,857 samples) dataset and 94.5%/93.6%/91.1% accuracy for direct tests on three unseen independent datasets (AIBL, 669 samples / MIRIAD, 644 samples / OASIS, 1,123 samples). When this AD classifier was tested on brain images from unseen mild cognitive impairment (MCI) patients, MCI patients who converted to AD were 3 times more likely to be predicted as AD than MCI patients who did not convert (65.2% vs. 20.6%). Predicted scores from the AD classifier showed significant correlations with illness severity. In sum, the proposed AD classifier offers a medical-grade marker that has potential to be integrated into AD diagnostic practice.
    Type of Medium: Online Resource
    ISSN: 2196-1115
    URL: Article
    DOI: 10.1186/s40537-022-00650-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2780218-8
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  • 2
    Online Resource
    Online Resource
    A Practical Alzheimer Disease Classifier via Brain Imaging-Based Deep Learning on 85,721 Samples: A Multicentre, Retrospective Cohort Study
    Elsevier BV ; 2021
    In:  SSRN Electronic Journal
    Details
    In: SSRN Electronic Journal, Elsevier BV
    Type of Medium: Online Resource
    ISSN: 1556-5068
    URL: Article
    DOI: 10.2139/ssrn.3980909
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder
    Oxford University Press (OUP) ; 2022
    In:  Psychoradiology Vol. 2, No. 1 ( 2022-06-09), p. 32-42
    Details
    In: Psychoradiology, Oxford University Press (OUP), Vol. 2, No. 1 ( 2022-06-09), p. 32-42
    Abstract: Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diagnosis boundaries. In addition, large-scale longitudinal studies targeting brain network alterations following antidepressant treatment, aggregation of diffusion tensor images, and the development of functional magnetic resonance imaging-guided neuromodulation approaches are underway. Through these endeavours, we hope to accelerate the translation of functional neuroimaging findings to clinical use, such as evaluating longitudinal effects of antidepressant medications and developing individualized neuromodulation targets, while building an open repository for the scientific community.
    Type of Medium: Online Resource
    ISSN: 2634-4416
    URL: Article
    DOI: 10.1093/psyrad/kkac005
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 3076092-6
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  • 4
    Online Resource
    Online Resource
    Development and evaluation of a predictive nomogram for survival in heat stroke patients: a retrospective cohort study
    World Journal of Emergency Medicine ; 2022
    In:  World Journal of Emergency Medicine Vol. 13, No. 5 ( 2022), p. 355-
    Details
    In: World Journal of Emergency Medicine, World Journal of Emergency Medicine, Vol. 13, No. 5 ( 2022), p. 355-
    Type of Medium: Online Resource
    ISSN: 1920-8642
    URL: Article
    DOI: 10.5847/wjem.j.1920-8642.2022.092
    Language: English
    Publisher: World Journal of Emergency Medicine
    Publication Date: 2022
    detail.hit.zdb_id: 2753264-1
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  • 5
    Online Resource
    Online Resource
    Outcome of bystander cardiopulmonary resuscitation after out-of-hospital cardiac arrest in Beijing
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Emergency and Critical Care Medicine Vol. 1, No. 2 ( 2021-12-1), p. 64-69
    Details
    In: Emergency and Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 1, No. 2 ( 2021-12-1), p. 64-69
    Abstract: We aimed to investigate the association between bystander cardiopulmonary resuscitation (CPR) and survival of patients with out-of-hospital cardiac arrests (OHCA) in Beijing. Methods: This observational study analyzed adult patients with OHCA treated by the Beijing emergency medical service (EMS) from January 2013 to December 2017. Data were collected in a Utstein style with a 1-year follow-up and a primary outcome of survival to hospital discharge. Secondary outcomes were return of spontaneous circulation (ROSC), survival to admission, favorable neurological outcome at hospital discharge, and survival and favorable neurological outcomes of up to 1 year. Results: A total of 5016 patients with OHCA from Beijing's urban area were recorded by EMS, wherein 765 patients (15.25%) underwent bystander CPR. The data were propensity score-matched forage, sex, location, witness, aetiology, initial rhythm, and call to EMS arrival to compare the difference between the occurrence and nonoccurrence of bystander CPR. The survival upon the discharge of patients who experienced bystander CPR was superior to that of patients who did not receive bystander CPR (3.7% vs 1.2%, respectively; P   〈  0.001). Moreover, patients with OHCA resuscitated with bystander CPR achieved better outcomes of ROSC, survival to admission, favorable neurological outcome at hospital discharge, survival and favorable neurological outcome after 1 year compared with those who were not resuscitated with bystander CPR. Conclusion: Survival and neurological outcome of patients who underwent bystander CPR was better than those who underwent nonbystander CPR in Beijing. However, the rate of bystander CPR was low.
    Type of Medium: Online Resource
    ISSN: 2693-860X
    URL: Article
    DOI: 10.1097/EC9.0000000000000002
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 3123831-2
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  • 6
    Online Resource
    Online Resource
    DL‐3‐n‐butylphthalide‐induced neuroprotection in rat models of asphyxia‐induced cardiac arrest followed by cardiopulmonary resuscitation
    Wiley ; 2021
    In:  Journal of Cellular Physiology Vol. 236, No. 11 ( 2021-11), p. 7464-7472
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 236, No. 11 ( 2021-11), p. 7464-7472
    Abstract: Most patients that resuscitate successfully from cardiac arrest (CA) suffer from poor neurological prognosis. DL‐3‐n‐butylphthalide (NBP) is known to have neuroprotective effects via multiple mechanisms. This study aimed to investigate whether NBP can decrease neurological impairment after CA. We studied the protective role of NBP in the hippocampus of a rat model of cardiac arrest induced by asphyxia. Thirty‐nine rats were divided randomly into sham, control, and NBP groups. Rats in control and NBP groups underwent cardiopulmonary resuscitation (CPR) 6 min after asphyxia. NBP or vehicle (saline) was administered intravenously 10 min after the return of spontaneous circulation (ROSC). Ultrastructure of hippocampal neurons was observed under transmission electron microscope. NBP treatment improved neurological function up to 72 h after CA. The ultrastructural lesion in mitochondria recovered in the NBP‐treated CA model. In conclusion, our study demonstrated multiple therapeutic benefits of NBP after CA.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v236.11
    DOI: 10.1002/jcp.30442
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Meteorological-Data-Driven Rubber Tree Powdery Mildew Model and Its Application on Spatiotemporal Patterns: A Case Study of Hainan Island
    MDPI AG ; 2023
    In:  Sustainability Vol. 15, No. 16 ( 2023-08-08), p. 12119-
    Details
    In: Sustainability, MDPI AG, Vol. 15, No. 16 ( 2023-08-08), p. 12119-
    Abstract: Given that rubber is an important strategic material and the prevalence of rubber tree powdery mildew (RTPM) is a serious issue, the study of RTPM is becoming increasingly significant in aiding our understanding and managing rubber plantations. By enhancing our understanding, we may improve both the yield and quality of the rubber produced. Using meteorological station and reanalysis data, we employed factor expansion and three different feature-selection methods to screen for significant meteorological factors, ultimately constructing a data-driven RTPM disease index (RTPM-DI) model. This model was then used to analyze the spatiotemporal distribution of RTPM-DI in Hainan Island from 1980 to 2018, to reproduce and explore its patterns. The results show that (1) the RTPM-DI is dominantly negatively influenced by the average wind speed and positively affected by days with moderate rain; (2) the average wind speed and the days with moderate rain could explain 71% of the interannual variations in RTPM-DI, and a model established on the basis of these can simulate the changing RTPM-DI pattern very well (RMSE = 8.2511, MAE = 6.7765, MAPE = 0.2486, KGE = 0.9921, MSE = 68.081, RMSLE = 0.0953); (3) the model simulation revealed that during the period from 1980 to 2018, oscillating cold spots accounted for 72% of the whole area of Hainan Island, indicating a declining trend in RTPM-DI in the middle, western, southwestern, and northwestern regions. Conversely, new hot-spots and oscillating hot-spots accounted for 1% and 6% of the entire island, respectively, demonstrating an upward trend in the southeastern and northern regions. Additionally, no discernible pattern was observed for 21% of the island, encompassing the southern, eastern, and northeastern regions. It is evident that the whole island displayed significant spatial differences in the RTPM-DI pattern. The RTPM-DI model constructed in this study enhances our understanding of how climate change impacts RTPM, and it provides a useful tool for investigating the formation mechanism and control strategies of RTPM in greater depth.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su151612119
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518383-7
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  • 8
    Online Resource
    Online Resource
    Insights into Dynamic Surface Bromide Sites in Bi 4 O 5 Br 2 for Sustainable N 2 Photofixation
    Wiley ; 2022
    In:  Angewandte Chemie Vol. 134, No. 19 ( 2022-05-02)
    Details
    In: Angewandte Chemie, Wiley, Vol. 134, No. 19 ( 2022-05-02)
    Abstract: Simulating photosynthesis has long been one of the ideas for realizing the conversion of solar energy into industrial chemicals. Heterogeneous N 2 photofixation in water is a promising way for sustainable production of ammonia. However, a mechanistic understanding of the complex aqueous photocatalytic N 2 reduction is still lacking. In this study, a light‐dependent surface hydrogenation mechanism and light‐independent protection of catalyst surface for N 2 reduction are revealed on ultrathin Bi 4 O 5 Br 2 (BOB) nanosheets, in which the creation and annihilation of surface bromine vacancies can be controlled via a surface bromine cycle. Our rapid scan in situ FT‐IR spectra verify that photocatalytic N 2 reduction proceeds through an associative alternating mechanism on BOB surface with bromine vacancies (BrV‐BOB). This work provides a new strategy to combine light‐dependent facilitated reaction with light‐independent regeneration of catalyst for advancing sustainable ammonia production.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v134.19
    DOI: 10.1002/ange.202200937
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 9
    Online Resource
    Online Resource
    Experimental study on hydraulic fracture propagation behavior of horizontal well on multilayered rock
    Springer Science and Business Media LLC ; 2023
    In:  Geomechanics and Geophysics for Geo-Energy and Geo-Resources Vol. 9, No. 1 ( 2023-12)
    Details
    In: Geomechanics and Geophysics for Geo-Energy and Geo-Resources, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2023-12)
    Abstract: A series of true axial hydraulic fracturing experiments were conducted to understand the complex hydraulic fracture initiation and propagation behavior of multilayered rocks. Moreover, a new and convenient grid measurement method was presented to describe hydraulic fracturing effectiveness. The experimental results revealed that transverse vertical and non-planar axial fractures could be created in the hydraulic fracturing of multilayered rocks. Moreover, the fracture area scanning results by the grid measurement method match the results indicated by the traditional Geomagic method. The fracture behavior close to the layer contact determines how complex the produced fishbone structure fracture system is. Near the hole zones, secondary axial and deviated transverse fractures were found due to multiple layers. The fracture system can be managed by modifying the fracturing treatment parameters. Low-principle horizontal stress contrast and low-viscosity fracturing fluid can produce complicated fractures, and an increase in perforation numbers can make the fracture more complex and produce abnormally high breakdown pressure. Larger fracture areas benefit from high perforation rates and pump rates, but larger fracture areas may not always benefit from a decreased fracturing fluid viscosity. The breakdown pressure was the highest for the samples with two sets of oriented perforations, and the stress shadowing effect should be considered in the multiple fracture treatment. The increase in the pump rate generates a more complex fracture path in the horizontal well despite the fracturing fluid types but also yields a high breakdown pressure. The increased fracturing fluid viscosity can constrain the random fracture extension, which is beneficial for decreasing the near-wellbore tortuosity. The occurrence of shear fracture along the interface in a multilayered formation could be a risk for proppant injection and placement.
    Type of Medium: Online Resource
    ISSN: 2363-8419 , 2363-8427
    URL: Article
    DOI: 10.1007/s40948-023-00601-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2823606-3
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  • 10
    Online Resource
    Online Resource
    Preparation, characterization and thermal properties of Lauryl alcohol/Kaolin as novel form-stable composite phase change material for thermal energy storage in buildings
    Elsevier BV ; 2013
    In:  Applied Thermal Engineering Vol. 59, No. 1-2 ( 2013-09), p. 336-347
    Details
    In: Applied Thermal Engineering, Elsevier BV, Vol. 59, No. 1-2 ( 2013-09), p. 336-347
    Type of Medium: Online Resource
    ISSN: 1359-4311
    URL: Article
    DOI: 10.1016/j.applthermaleng.2013.05.015
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 2019322-1
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