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  • 1
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    Abdominal Wall Defects in Greenland 1989–2015
    Wiley ; 2017
    In:  Birth Defects Research Vol. 109, No. 11 ( 2017-07-03), p. 836-842
    Details
    In: Birth Defects Research, Wiley, Vol. 109, No. 11 ( 2017-07-03), p. 836-842
    Abstract: In the last decades, an increasing rate of gastroschisis but not of omphalocele has been reported worldwide. Greenland is the world's largest island, but 80% is covered by an ice cap, it has a small population of around 56,000 peoples (as of 2016). The occurrence of abdominal wall defects has never been investigated in Greenland. Methods The present study is based on data retrieved from three nationwide and two local registries in the Greenlandic health care system over 27 years (1989–2015). Results We identified 33 infants with abdominal wall defects born in the study time period. All cases were reclassified to 28 cases of gastroschisis, four cases of omphalocele, and there was 1 infant in the indeterminate group. The point prevalence at birth for gastroschisis increased significantly from 8 to 35 (average 10.7) per 10,000 liveborn and ‐stillborn infants. Mothers below 20 years of age represented 23% of all cases and the prevalence for this group was 17 per 10,000 liveborn and stillborn. Perinatal mortality for infants with gastroschisis was high (18%), and 1 year survival was 71%. For omphalocele, the prevalence varied from 8 to 11 per 10,000 liveborn and stillborn infants. There was no increasing rate in the period, further highlighting an etiological difference between gastroschisis and omphalocele. Conclusion This study confirms the increasing prevalence of gastroschisis in Greenland in the period from 1989 to 2015. The average was 10.7 per 10,000 liveborn and ‐stillborn infants and, to the best of our knowledge, this is the highest prevalence ever reported. Birth Defects Research 109:836–842, 2017. © 2017 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 2472-1727 , 2472-1727
    URL: Issue
    URL: Article
    DOI: 10.1002/bdr2.v109.11
    DOI: 10.1002/bdr2.1025
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2884154-2
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  • 2
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    Incidence of airflow limitation among employees in Norwegian smelters
    Wiley ; 2011
    In:  American Journal of Industrial Medicine Vol. 54, No. 9 ( 2011-09), p. 707-713
    Details
    In: American Journal of Industrial Medicine, Wiley, Vol. 54, No. 9 ( 2011-09), p. 707-713
    Abstract: We have investigated the association between the incidence of airflow limitation and occupational exposure. The employees (n = 3,924) were investigated annually during five years (n = 16,570) using spirometry. Exposure was classified using job category and a job exposure matrix. Airflow limitation was expressed using two indices: (i) as forced expiratory volume in one second/force vital capacity (FEV 1 /FVC) 〈 0.7 and (ii) lower limit of normal (LLN). The incidence of airflow limitation was 21.2/1000 years −1 and 15.1/1000 years −1 using the fixed limit (0.7) and the LLN criterion, respectively. We found a dose–response relationship between the incidence of airflow limitation and tobacco consumption and with job‐category in non‐smokers. The associations between airflow limitation and covariates were independent of how airflow limitation was defined. The incidence of airflow limitation defined as FEV l /FVC 〈 0.7 yielded higher incidence rates of airflow limitation than LLN. We found a significant association between the incidence of airflow limitation and occupational exposure in non‐smokers. Am. J. Ind. Med. 54:707–713, 2011. © 2011 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0271-3586 , 1097-0274
    URL: Issue
    URL: Article
    DOI: 10.1002/ajim.v54.9
    DOI: 10.1002/ajim.20946
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1491156-5
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  • 3
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    Prevalence of airflow limitation among employees in Norwegian smelters: a longitudinal study
    BMJ ; 2011
    In:  Occupational and Environmental Medicine Vol. 68, No. 1 ( 2011-01), p. 24-29
    Details
    In: Occupational and Environmental Medicine, BMJ, Vol. 68, No. 1 ( 2011-01), p. 24-29
    Abstract: To investigate the association between airflow limitation and occupational exposure and to compare a fixed limit with an age adjusted limit for airflow limitation. Methods 3924 employees in 24 Norwegian smelters and related workplaces were investigated annually over 5 years (n=16 570) using spirometry and a respiratory questionnaire on smoking habits and job category. Employees working full time on the production line were classified as line operators; subjects who never worked on the production line were regarded as non-exposed. A job exposure matrix (JEM) was available in most smelters. Airflow limitation was expressed as (i) forced expiratory volume in 1 s/forced vital capacity (FEV 1 /FVC ratio) 〈 0.7 and (ii) FEV 1 /FVC ratio less than the lower limit of normal (LLN). Longitudinal analyses on the prevalence of airflow limitation were performed using a generalised linear mixed model. Results The prevalence of airflow limitation was stable during follow-up. The OR of airflow limitation during follow-up was 1.24 (95% CI 1.03 to 1.50) in line operators compared with unexposed subjects for FEV 1 /FVC ratio 〈 0.7 and 1.44 (1.14 to 1.81) for FEV 1 /FVC ratio 〈 LLN. A dose–response relationship was also found between prevalence of airflow limitation and dust exposure. The annual decline in FEV 1 was −77.5 (SD 99.9) ml/year in subjects with FEV 1 /FVC ratio 〈 0.7 and −83.8 (114.2) ml/year in subjects with FEV 1 /FVC ratio 〈 LLN. Conclusion Prevalence of airflow limitation was higher in exposed than non-exposed employees. Both the FEV 1 /FVC ratio 〈 0.7 and FEV 1 /FVC ratio 〈 LLN identify subjects with accelerated annual decline in FEV 1 .
    Type of Medium: Online Resource
    ISSN: 1351-0711 , 1470-7926
    URL: Article
    DOI: 10.1136/oem.2009.049452
    Language: English
    Publisher: BMJ
    Publication Date: 2011
    detail.hit.zdb_id: 2020276-3
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  • 4
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    Firefighting and melanoma, epidemiological and toxicological associations: a case report
    Oxford University Press (OUP) ; 2022
    In:  Occupational Medicine Vol. 72, No. 2 ( 2022-02-22), p. 142-144
    Details
    In: Occupational Medicine, Oxford University Press (OUP), Vol. 72, No. 2 ( 2022-02-22), p. 142-144
    Abstract: The International Agency for Research on Cancer (IARC) classifies firefighting as possibly carcinogenic to humans, and polychlorinated biphenyls (PCBs) as carcinogens with sufficient evidence for development of melanoma in humans. We present a case report of a firefighter with melanoma and history of 33 years of occupational exposure. Based on the available epidemiological and toxicological evidence of association between being a firefighter and developing melanoma, melanoma was recognized by the Norwegian Labour and Welfare Service as an occupational disease in our patient. In 2017, melanoma was acknowledged as an occupational disease in only 8 out of 28 surveyed European countries. Melanoma should be considered as a possible occupational disease among firefighters with a history of relevant exposure. Further recognition of the occupational exposures leading to increased risk of melanoma is still needed for preventive purposes.
    Type of Medium: Online Resource
    ISSN: 0962-7480 , 1471-8405
    URL: Article
    DOI: 10.1093/occmed/kqab183
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2042824-8
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  • 5
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    The Genetic Basis of the Pierre Robin Sequence
    SAGE Publications ; 2005
    In:  The Cleft Palate-Craniofacial Journal ( 2005)
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, ( 2005)
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1597/05-008
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2005
    detail.hit.zdb_id: 2030056-6
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  • 6
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    The Genetic Basis of the Pierre Robin Sequence
    SAGE Publications ; 2006
    In:  The Cleft Palate-Craniofacial Journal Vol. 43, No. 2 ( 2006-03), p. 155-159
    Details
    In: The Cleft Palate-Craniofacial Journal, SAGE Publications, Vol. 43, No. 2 ( 2006-03), p. 155-159
    Abstract: The Pierre Robin Sequence (PRS) is subgroup of the cleft palate population. As with the etiology of cleft lip or palate, the etiology of PRS is generally unknown. Some factors are suggestive of a genetic basis for PRS. The purpose of this study was to compare genetic information on PRS available in the literature and in a cytogenetic database to facilitate focused genetic studies of PRS. Design After searching Medline for “pierre robin and genetics,” the Mendelian Cytogenetics Network database for “robin” and “pierre robin,” and two reviews from the Human Cytogenetics Database for “cleft palate” and “micrognathia,” a comparison of the data and a search in Online Mendelian Inheritance in Man (OMIM) Gene Map was performed to identify relevant candidate genes. Results The findings revealed consistency to a certain degree to loci 2q24.1-33.3, 4q32-qter, 11q21-23.1, and 17q21-24.3. A search in the OMIM Gene Map provided many candidate genes for PRS in these regions. The GAD67 on 2q31, the PVRL1 on 11q23-q24, and the SOX9 gene on 17q24.3-q25.1 are suggested to be of particular importance. Conclusion Candidate loci and a few potential candidate genes for PRS are proposed from the present study. This may enable researchers to focus their effort in the studies of PRS.
    Type of Medium: Online Resource
    ISSN: 1055-6656 , 1545-1569
    URL: Article
    DOI: 10.1597/05-008.1
    RVK:
    XA 36625
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2030056-6
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  • 7
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    Twins with omphalocele in Denmark (1970–1989)
    Wiley ; 2010
    In:  American Journal of Medical Genetics Part A Vol. 152A, No. 8 ( 2010-08), p. 2048-2052
    Details
    In: American Journal of Medical Genetics Part A, Wiley, Vol. 152A, No. 8 ( 2010-08), p. 2048-2052
    Abstract: Seven pairs of twins, two monozygotic (MZ), two dizygotic (DZ), and three like‐sex pairs of unknown zygosity are described. The twin pairs were all discordant for omphalocele except for one pair of conjoined twins. The 8 infants with omphalocele represent 3.1% of the 253 infants with omphalocele, ascertained in an almost complete nationwide data set of live‐ and stillborn infants with abdominal wall defects in two decades in Denmark (1970–1989). The occurrence of twins with omphalocele was not significantly different from the occurrence of twins in the Danish population in the same period. To our knowledge this is the first report of the occurrence of twins with omphalocele in a systematic nationwide epidemiological study. © 2010 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1552-4825 , 1552-4833
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.a.v152a:8
    DOI: 10.1002/ajmg.a.33494
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1493479-6
    SSG: 12
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  • 8
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    International Inventory of Occupational Exposure Information: OMEGA-NET
    Oxford University Press (OUP) ; 2020
    In:  Annals of Work Exposures and Health Vol. 64, No. 5 ( 2020-06-24), p. 465-467
    Details
    In: Annals of Work Exposures and Health, Oxford University Press (OUP), Vol. 64, No. 5 ( 2020-06-24), p. 465-467
    Type of Medium: Online Resource
    ISSN: 2398-7308 , 2398-7316
    URL: Article
    DOI: 10.1093/annweh/wxaa021
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2003484-2
    detail.hit.zdb_id: 2885099-3
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  • 9
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    Occupational Exposure Assessment Tools in Europe: A Comprehensive Inventory Overview
    Oxford University Press (OUP) ; 2022
    In:  Annals of Work Exposures and Health Vol. 66, No. 5 ( 2022-06-06), p. 671-686
    Details
    In: Annals of Work Exposures and Health, Oxford University Press (OUP), Vol. 66, No. 5 ( 2022-06-06), p. 671-686
    Abstract: The Network on the Coordination and Harmonisation of European Occupational Cohorts (OMEGA-NET) was set up to enable optimization of the use of industrial and general population cohorts across Europe to advance aetiological research. High-quality harmonized exposure assessment is crucial to derive comparable results and to enable pooled analyses. To facilitate a harmonized research strategy, a concerted effort is needed to catalogue available occupational exposure information. We here aim to provide a first comprehensive overview of exposure assessment tools that could be used for occupational epidemiological studies. Methods An online inventory was set up to collect meta-data on exposure assessment tools. Occupational health researchers were invited via newsletters, editorials, and individual e-mails to provide details of job-exposure matrices (JEMs), exposure databases, and occupational coding systems and their associated crosswalks to translate codes between different systems, with a focus on Europe. Results Meta-data on 36 general population JEMs, 11 exposure databases, and 29 occupational coding systems from more than 10 countries have been collected up to August 2021. A wide variety of exposures were covered in the JEMs on which data were entered, with dusts and fibres (in 14 JEMs) being the most common types. Fewer JEMs covered organization of work (5) and biological factors (4). Dusts and fibres were also the most common exposures included in the databases (7 out of 11), followed by solvents and pesticides (both in 6 databases). Conclusions This inventory forms the basis for a searchable web-based database of meta-data on existing occupational exposure information, to support researchers in finding the available tools for assessing occupational exposures in their cohorts, and future efforts for harmonization of exposure assessment. This inventory remains open for further additions, to enlarge its coverage and include newly developed tools.
    Type of Medium: Online Resource
    ISSN: 2398-7308 , 2398-7316
    URL: Article
    DOI: 10.1093/annweh/wxab110
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2003484-2
    detail.hit.zdb_id: 2885099-3
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  • 10
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    Mutations in autism susceptibility candidate 2 (AUTS2) in patients with mental retardation
    Springer Science and Business Media LLC ; 2007
    In:  Human Genetics Vol. 121, No. 3-4 ( 2007-4-4), p. 501-509
    Details
    In: Human Genetics, Springer Science and Business Media LLC, Vol. 121, No. 3-4 ( 2007-4-4), p. 501-509
    Type of Medium: Online Resource
    ISSN: 0340-6717 , 1432-1203
    URL: Article
    DOI: 10.1007/s00439-006-0284-0
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2007
    detail.hit.zdb_id: 1459188-1
    SSG: 12
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