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  • 1
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1999
    In:  Visual Neuroscience Vol. 16, No. 1 ( 1999-01), p. 1-14
    In: Visual Neuroscience, Cambridge University Press (CUP), Vol. 16, No. 1 ( 1999-01), p. 1-14
    Abstract: Signals relayed through the magnocellular layers of the LGN travel on axons with faster conduction speeds than those relayed through the parvocellular layers. As a result, magnocellular signals might reach cerebral cortex appreciably before parvocellular signals. The relative speed of these two channels cannot be accurately predicted based solely on axon conduction speeds, however. Other factors, such as different degrees of convergence in the magnocellular and parvocellular channels and the retinal circuits that feed them, can affect the time it takes for magnocellular and parvocellular signals to activate cortical neurons. We have investigated the relative timing of visual responses mediated by the magnocellular and parvocellular channels. We recorded individually from 78 magnocellular and 80 parvocellular neurons in the LGN of two anesthetized monkeys. Visual response latencies were measured for small spots of light of various intensities. Over a wide range of stimulus intensities the fastest magnocellular response latencies preceded the fastest parvocellular response latencies by about 10 ms. Because parvocellular neurons are far more numerous than magnocellular neurons, convergence in cortex could reduce the magnocellular advantage by allowing parvocellular signals to generate detectable responses sooner than expected based on the responses of individual parvocellular neurons. An analysis based on a simple model using neurophysiological data collected from the LGN shows that convergence in cortex could eliminate or reverse the magnocellular advantage. This observation calls into question inferences that have been made about ordinal relationships of neurons based on timing of responses.
    Type of Medium: Online Resource
    ISSN: 0952-5238 , 1469-8714
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1999
    detail.hit.zdb_id: 1489922-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Veterinary Clinics of North America: Small Animal Practice Vol. 48, No. 1 ( 2018-01), p. 45-62
    In: Veterinary Clinics of North America: Small Animal Practice, Elsevier BV, Vol. 48, No. 1 ( 2018-01), p. 45-62
    Type of Medium: Online Resource
    ISSN: 0195-5616
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    SSG: 22
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  • 3
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 237, No. 7 ( 2010-10-01), p. 812-822
    Abstract: Objective —To compare signalment of horses with cervical vertebral malformation-malarticulation (CVM) with that of control horses and to describe results of clinical examination, diagnostic imaging and necropsy findings, and reported outcome in horses with CVM. Design —Retrospective case-control study. Animals —270 horses with CVM and 608 control horses admitted to 6 veterinary hospitals from 1992 through 2007. Procedures —Medical records of participating hospitals were reviewed to identify horses with CVM (ie, case horses) and contemporaneous control (non-CVM-affected) horses that were admitted for treatment. Signalment was compared between case horses and control horses. Results of clinical examination, laboratory and diagnostic imaging findings, necropsy results, and outcome were assessed for horses with CVM. Results —Case horses were younger (median age, 2 years) than were control horses (median age, 7 years). Thoroughbreds, warmbloods, and Tennessee Walking Horses were overrepresented in the CVM group. Gait asymmetry and cervical hyperesthesia were frequently detected in horses with CVM. Vertebral canal stenosis and articular process osteophytosis were commonly observed at necropsy; agreement between the results of radiographic or myelographic analysis and detection of lesions at necropsy was 65% to 71% and 67% to 78%, respectively. Of 263 horses with CVM for which outcome was recorded, 1 died and 172 (65.4%) were euthanatized. Conclusions and Clinical Relevance —Odds of a diagnosis of CVM were greater in young horses and horses of specific breeds. Detection of gait asymmetry and cervical hyperesthesia were frequently reported in association with CVM. Accurate diagnosis of lesions associated with CVM by use of radiography and myelography can be challenging. ( J Am Vet Med Assoc 2010;237:812-822)
    Type of Medium: Online Resource
    ISSN: 0003-1488
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2010
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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