In:
Proteins: Structure, Function, and Bioinformatics, Wiley, Vol. 70, No. 2 ( 2008-02), p. 473-488
Kurzfassung:
Neuronal ion‐channels are complex multimeric proteins. Within a given family, the variability of their pharmacological responses depends on subunit composition and subunit arrangement. We report here that protein assembly in the pentameric nicotinic acetylcholine receptor family, the best characterized of all neuronal receptors, can be predicted using information derived from homology modeled surface to surface subunit interactions based on the atomic structure of a snail acetylcholine‐binding protein. An empirical assembly model is able to establish both subunit stoichiometry and subunit arrangement of known neuronal and muscle nicotinic receptors. This contribution to the understanding of nicotinic receptor assembly and variability might be extended to other types of ion‐channels. Proteins 2008. © 2007 Wiley‐Liss, Inc.
Materialart:
Online-Ressource
ISSN:
0887-3585
,
1097-0134
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2008
ZDB Id:
1475032-6
SSG:
12
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