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  • 1
    Online Resource
    Online Resource
    BJS commission on surgery and perioperative care post-COVID-19
    Oxford University Press (OUP) ; 2021
    In:  British Journal of Surgery Vol. 108, No. 10 ( 2021-10-23), p. 1162-1180
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 108, No. 10 ( 2021-10-23), p. 1162-1180
    Abstract: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues’ experiences and published evidence. Methods In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1093/bjs/znab307
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2006309-X
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  • 2
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    Protective Effect of Allium sativum and Nigella sativa Against NO-Mediated Alterations in Dimethylhydrazine- Induced Colon Cancer rats.
    Egypts Presidential Specialized Council for Education and Scientific Research ; 2004
    In:  The Egyptian Journal of Hospital Medicine Vol. 15, No. 1 ( 2004-04-01), p. 1-14
    Details
    In: The Egyptian Journal of Hospital Medicine, Egypts Presidential Specialized Council for Education and Scientific Research, Vol. 15, No. 1 ( 2004-04-01), p. 1-14
    Type of Medium: Online Resource
    ISSN: 2090-7125
    URL: Article
    DOI: 10.21608/ejhm.2004.18182
    Language: English
    Publisher: Egypts Presidential Specialized Council for Education and Scientific Research
    Publication Date: 2004
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  • 3
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    Preparation of chemically stable allergen‐specific sublingual immunotherapy from Egyptian allergens
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 3 ( 2022-03)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 3 ( 2022-03)
    Abstract: The term “allergen extracts” refers to solutions of proteins or glycoproteins extracted from source raw materials. Objectives This study was planned to prepare chemically stable sublingual immunotherapy from different allergens in Egypt. Methods Allergen extraction from raw materials. The concentrated aqueous extract of each allergen was mixed with an equal volume of glycerol. The protein content of the preparations was determined using the modified Lowry assay method. The prepared allergens were stored for 9 months at 2–4°C. Samples were analyzed periodically (0, 3, 6, and 9 months of intervals) adopting the Lowry Assay method. Levels of specific IgE to Chenopodium album antigens were measured in patients’ sera by ELISA. Results The concentration of all prepared allergens, as indicated by the concentration of the protein content, was found to decrease exponentially with time, implying first‐order kinetics of degradation. From the values of the slopes of the log plot for each allergen, the half‐life time ( t 1/2 ) and ( t 1/4 ) values were calculated. The expiration date was considered as the time after which the allergen loses 25% of its potency. The obtained values of t 1/4% vary according to the type of vaccine. The most stable one is that of Chenopodium album pollens (2.4 years) and the least stable is that of house dust Mites (9 months). The immunological characters of Chenopodium album extract were stable for at least 6 months. Conclusion Differences exist among allergen extracts made by multiple manufacturers. So, developments in studies on allergen preparation and characterization in a different locality are necessary.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.3
    DOI: 10.1002/jcla.24261
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001635-9
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  • 4
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    Potential Therapeutic Effects of Morin Hydrate in Folic Acid-Induced Acute Kidney Injury
    Oxford University Press (OUP) ; 2022
    In:  American Journal of Clinical Pathology Vol. 158, No. Supplement_1 ( 2022-11-09), p. S72-S73
    Details
    In: American Journal of Clinical Pathology, Oxford University Press (OUP), Vol. 158, No. Supplement_1 ( 2022-11-09), p. S72-S73
    Abstract: Acute kidney injury (AKI) causes significant morbidity and mortality and, if left unmanaged, can progress to chronic kidney disease. Despite the advances in our understanding of the pathogenesis of AKI, there are no available therapeutics to combat it effectively. Folic acid (FA)-induced AKI is a well established rat model characterized by acute renal injury due to the disturbance of the antioxidant system with subsequent renal fibrosis. Morin hydrate, a well-known bioactive flavonoid, has been proven to alleviate oxidative stress and exhibits anti- inflammatory, anti-apoptotic and neuroprotective activity. Methods/Case Report We investigated the potential protective and therapeutic effects of morin hydrate on FA-induced AKI. Thirty-five rats were divided randomly into 5 groups (6 rats/ group) as follows: control group received a vehicle for 10 days, FA group received a vehicle for 10 days with an intraperitoneal (IP) injection of a single dose (SD) of FA (250 mg/kg) on the 7thday, FA-Withdrawal group injected with a SD of FA (250 mg/kg IP) on the 1st day with a vehicle for 10 days, morin-pretreated group received morin hydrate (40 mg/kg orally) for 7 days, followed by a SD of FA (250 mg/kg, i.p), and morin-treated group injected with a SD of FA (250 mg/kg IP), then treated with morin hydrate (40 mg/kg orally) for 7 consecutive days. All animals were sacrificed after 10 days and then, blood samples and kidneys were collected for biochemical and histopathological examination. Results (if a Case Study enter NA) FA group showed extensive structural damage in renal tubules and glomeruli with no significant improvement in withdrawal and morin-pretreated groups. Morin treatment significantly attenuated histopathological changes and reduced FA-induced increase in serum creatinine, albumin and urea levels. This therapeutic role of morin was associated with suppression of inflammation, oxidative stress, and apoptosis. Conclusion These findings suggest that morin hydrate constitutes a potential natural therapeutic product for treating AKI.
    Type of Medium: Online Resource
    ISSN: 0002-9173 , 1943-7722
    URL: Article
    DOI: 10.1093/ajcp/aqac126.148
    RVK:
    YV 2000
    RVK:
    XA 18700
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2039921-2
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  • 5
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    Gamma Radiation Induced Synthesis of Novel Chitosan/Gold/Bioactive Glass Nanocomposite for Promising Antimicrobial, and Antibiofilm Activities
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Cluster Science Vol. 34, No. 4 ( 2023-07), p. 1877-1891
    Details
    In: Journal of Cluster Science, Springer Science and Business Media LLC, Vol. 34, No. 4 ( 2023-07), p. 1877-1891
    Abstract: In the present study we reported, for the first time, the gamma irradiation induced synthesis of chitosan/Au/bioactive glass (CS/Au/BG) nanocomposite. The bioactive glass (BG), with the composition 45% SiO 2 , 32.5% CaO, 15% Na 2 O, and 7.5% P 2 O 5 wt% was synthesized through the sol–gel technique. XRD, SEM, EDX, and elemental mapping images were utilized to evaluate the structure of pure BG and CS/Au/BG nanocomposite. The antimicrobial efficacy was evaluated by zone of inhibition (ZOI), minimum inhibitory concentration (MIC), growth curve assay, and Ultraviolet irradiation effect. Investigation was carried on the antibiofilm effectiveness. Membrane leakage as well as SEM imaging were used to evaluate the antibacterial reaction mechanism. The crystallite size of CS/Au/BG nanocomposite was determined via Scherer equation as 22.83 nm. CS/Au/BG possessed the most ZOI activity against the tested microbes. The highest inhibition % of BG, and CS/Au/BG nanocomposite was investigated for S. aureus (15.65%, and 77.24%), followed by C. albicans (13.32%, and 64.75%). The quantity of protein leakage was directly-proportional after increasing the concentration of BG, and CS/Au/BG and counted to be 70.58, and 198.25 µg/mL, respectively (after applied 10 mg/mL). The promising results suggested the use of novel CS/Au/BG nanocomposite as an encourage candidate for wastewater treatment application against pathogenic microbes.
    Type of Medium: Online Resource
    ISSN: 1040-7278 , 1572-8862
    URL: Article
    DOI: 10.1007/s10876-022-02357-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2016762-3
    SSG: 11
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  • 6
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    Synthesis, characterization and optical properties of multi-walled carbon nanotubes/aniline-o-anthranilic acid copolymer nanocomposite thin films
    Springer Science and Business Media LLC ; 2018
    In:  Journal of Materials Science: Materials in Electronics Vol. 29, No. 19 ( 2018-10), p. 16702-16714
    Details
    In: Journal of Materials Science: Materials in Electronics, Springer Science and Business Media LLC, Vol. 29, No. 19 ( 2018-10), p. 16702-16714
    Type of Medium: Online Resource
    ISSN: 0957-4522 , 1573-482X
    URL: Article
    DOI: 10.1007/s10854-018-9763-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2016994-2
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  • 7
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    Pepsin assay: A marker for reflux in pediatric glue ear
    Wiley ; 2007
    In:  Otolaryngology–Head and Neck Surgery Vol. 136, No. 3 ( 2007-03), p. 464-470
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 136, No. 3 ( 2007-03), p. 464-470
    Abstract: To evaluate if analysis of pepsin/pepsinogen in middle ear effusions can be considered a diagnostic marker for laryngopharyngeal reflux (LPR) in children with otitis media with effusion (OME). Material and Methods Ambulatory 24‐hour dualprobe pH monitoring was carried out on 31 children with OME. Middle ear effusions were collected from 17 children during myringotomy. Total pepsin/pepsinogen concentrations in effusions were measured by ELISA using antipepsin antibody. Results Dual‐probe pH monitoring showed that 22/31 (71%) of the studied children had significant LPR. The concentrations of pepsin/pepsinogen in middle ear effusions, ranged from 0.085 to 5.02 μg/ml, were found to be up to 4.5 to 231.44 times higher than the serum levels. There was a significant positive correlation between the level of pepsin/pepsinogen assayed in the effusions of the 17 children and the number of pharyngeal reflux episodes measured by pH monitoring. Conclusions Control of LPR may be an essential component in the successful management of OME in pediatric patients. Pepsin/pepsinogen analysis in effusions of children, using ELISA, can be considered a reliable marker for assessment of reflux in children with OME. © 2007 American Academy of Otolaryngology‐Head and Neck Surgery Foundation. All rights reserved.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1016/j.otohns.2006.08.030
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2008453-5
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  • 8
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    Comparative study of the antioxidant, toxicity, anti-inflammatory, and wound healing activities of both Digenea simplex polysaccharides and their corresponding (ZnO–Au) bimetallic nanoparticles
    Springer Science and Business Media LLC ; 2023
    In:  Cellulose Vol. 30, No. 1 ( 2023-01), p. 303-321
    Details
    In: Cellulose, Springer Science and Business Media LLC, Vol. 30, No. 1 ( 2023-01), p. 303-321
    Abstract: The development of green nanoparticle synthesis has multiple benefits over conventional physico-chemical techniques and provides a wide range of medical and biological applications. This study aims to synthesize zinc oxide nanoparticles (ZnONPs), gold nanoparticles (AuNPs), and bimetallic nanoparticles (BMNPs) from red algae Digenea simplex ( D. simplex ) polysaccharides and evaluate their antioxidant, toxicity, anti-inflammatory, and wound healing properties. High-performance liquid chromatography (HPLC) analysis was used to analyze D. simplex polysaccharides (PS). The NPs were characterized by using UV–visible (UV–vis), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM). ZnONPs showed rods and hexagonal shapes with particle sizes of 5–40 nm, AuNPs showed a spherical shape with particle sizes of 10–15 nm, and Zn-AuNPs showed a spherical shape with particle sizes of 10–40 nm. The scanning electron microscopy confirmed the presence of NPs on the cotton fabric surface in both washed and unwashed samples. The PS, ZnONPs, AuNPs and BMNPs had a good percentage of ABTS (3-ethylbenzothiazoline-6-sulphonic acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, with inhibition values for ABTS of 157.1, 72.78, 78.46, and 62.81 µg/ml, and for DPPH of 364.1, 105.0, 129.9, 76.07 µg/ml respectively. The anti-inflammatory properties of BMNPs of 85.44% and ZnONPs reached 76.58% were greater than those of AuNPs of 71.51% and PS 68.98%. Furthermore, the wound healing study revealed that BMNPs have the maximum percentage reduction of 81.87%, followed by its 10 washes of 76.78%, and reached of 71.60%, 56.36%, and 51.50% for ZnONPs, AuNPs, and PS, respectively.
    Type of Medium: Online Resource
    ISSN: 0969-0239 , 1572-882X
    URL: Article
    DOI: 10.1007/s10570-022-04878-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1496831-9
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