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  • 1
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    Online Resource
    Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
    Oxford University Press (OUP) ; 2020
    In:  British Journal of Surgery Vol. 107, No. 2 ( 2020-01-05), p. e161-e169
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 107, No. 2 ( 2020-01-05), p. e161-e169
    Abstract: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results A total of 4164 patients were included, with a median age of 68 (i.q.r. 57–75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1–3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P & lt; 0·001). Conclusion NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11326
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2006309-X
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  • 2
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    Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
    Oxford University Press (OUP) ; 2022
    In:  BJS Open Vol. 6, No. 1 ( 2022-01-06)
    Details
    In: BJS Open, Oxford University Press (OUP), Vol. 6, No. 1 ( 2022-01-06)
    Abstract: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
    Type of Medium: Online Resource
    ISSN: 2474-9842
    URL: Article
    DOI: 10.1093/bjsopen/zrab150
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2902033-5
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  • 3
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    Safety of hospital discharge before return of bowel function after elective colorectal surgery
    Oxford University Press (OUP) ; 2020
    In:  British Journal of Surgery Vol. 107, No. 5 ( 2020-03-18), p. 552-559
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 107, No. 5 ( 2020-03-18), p. 552-559
    Abstract: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien–Dindo classification system. Results A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4–7) and 7 (6–8) days respectively (P & lt; 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110). Conclusion Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11422
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2006309-X
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  • 4
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    Tree pollen peaks are associated with increased nonviolent suicide in women
    Springer Science and Business Media LLC ; 2005
    In:  Molecular Psychiatry Vol. 10, No. 3 ( 2005-03-01), p. 232-235
    Details
    In: Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 10, No. 3 ( 2005-03-01), p. 232-235
    Type of Medium: Online Resource
    ISSN: 1359-4184 , 1476-5578
    URL: Article
    DOI: 10.1038/sj.mp.4001620
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2005
    detail.hit.zdb_id: 1502531-7
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  • 5
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    Author response to: Comment on: Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
    Oxford University Press (OUP) ; 2020
    In:  British Journal of Surgery Vol. 107, No. 3 ( 2020-01-23), p. 317-317
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 107, No. 3 ( 2020-01-23), p. 317-317
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11482
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2006309-X
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  • 6
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    FACTORS ASSOCIATED WITH UNMET NEED AMONG FAMILY CAREGIVERS
    Oxford University Press (OUP) ; 2019
    In:  Innovation in Aging Vol. 3, No. Supplement_1 ( 2019-11-08), p. S386-S386
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 3, No. Supplement_1 ( 2019-11-08), p. S386-S386
    Abstract: This study investigates the relationship between caregiver demographics, caregiving intensity, caregiver support use, and aspects of the caregiving situation with perceived unmet need. The data source was survey response data from 1,558 informal caregivers caring for older adults (age 60+) or caring for any adult with Alzheimer’s disease or related dementia (ADRD). Participants were randomly recruited through U.S. Area Agencies on Aging client lists of any service and interviewed in December 2016. Caregivers were asked, “Are you receiving all the help you need?” Twenty-two percent (n=345) said “Definitely No” and were classified as having unmet need. We placed caregivers in tertiles based on their Zarit burden score; unmet need was 14% among low burden, 20% among medium, and 34% among high. The mean age of the care recipient (CR) was 81 years. Caregivers were 70% non-Hispanic White, 52% caring for CR with ADRD, and 43% spouse of CR. A multivariable logistic regression found two predictive factors (odds ratio p-value & lt; 0.01) that increased the likelihood of reporting unmet need: daily intensity of caregiving and not feeling appreciated by CR. Usage of caregiver education, counseling or support group services in the past 6 months decreased the likelihood of reporting unmet need. In the high burden subgroup, Black caregivers were more likely to report unmet need than White caregivers. Understanding the relationship between caregiver demographics, self-reported burden level, service use, and the caregiver’s need for more help can assist caregiver support programs in assessing, measuring, and addressing the ongoing needs of caregivers.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igz038.1417
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2905697-4
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  • 7
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    Rotating Gliding Arc: Innovative Source for VOC Remediation
    Czech Technical University in Prague - Central Library ; 2019
    In:  PLASMA PHYSICS AND TECHNOLOGY Vol. 6, No. 2 ( 2019-09-10), p. 156-160
    Details
    In: PLASMA PHYSICS AND TECHNOLOGY, Czech Technical University in Prague - Central Library, Vol. 6, No. 2 ( 2019-09-10), p. 156-160
    Abstract: The large-scale plasma treatment of waste gas in industrial or municipal conditions requires high efficiency of plasma conversion process at high processing speed, i.e., large volumetric flow. The integration of the plasma unit into existing systems puts demands on the pipe-system compatibility and minimal pressure drop due to adoption of plasma processing step. These conditions are met at the innovative rotating electrode gliding arc plasma unit described in this article. The system consists of propeller-shaped high voltage electrode inside grounded metallic tube. The design of HV electrode eliminates the pressure drop inside the air system, contrary the plasma unit itself is capable of driving the waste gas at volumetric flow up to 300 m3/hr for 20 cm pipe diameter. In the article the first results on pilot study of waste air treatment will be given for selected volatile organic compounds together with basic characteristic of the plasma unit used.
    Type of Medium: Online Resource
    ISSN: 2336-2634 , 2336-2626
    URL: Article
    DOI: 10.14311/ppt.2019.2.156
    Language: Unknown
    Publisher: Czech Technical University in Prague - Central Library
    Publication Date: 2019
    detail.hit.zdb_id: 2835712-7
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  • 8
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    The Effect of National Family Caregiver Support Program Services on Caregiver Burden
    SAGE Publications ; 2021
    In:  Journal of Applied Gerontology Vol. 40, No. 9 ( 2021-09), p. 963-971
    Details
    In: Journal of Applied Gerontology, SAGE Publications, Vol. 40, No. 9 ( 2021-09), p. 963-971
    Abstract: Extant evidence on the effectiveness of caregiver programs in alleviating caregiver burden is mixed, underscoring the need for further investigations. This study evaluated the effect of the National Family Caregiver Support Program (NFCSP) educational services and respite care on caregiver burden. We used survey data from caregivers assigned to program ( n = 491) or comparison ( n = 417) group based on their reported use of NFCSP services. Adjusted difference-in-differences (DiD) analysis found an increase in mean burden scores for both groups from baseline to 6 or 12 months. Among program caregivers receiving ≥4 hr of NFCSP respite care per week ( n = 307) and matched comparisons ( n = 370), burden scores decreased slightly for program caregivers (−0.095 points), but increased for comparison caregivers (+0.145 points). The DiD (0.239 points) was not statistically significant. More research is needed to determine the minimum amount of respite care needed to positively impact caregiver burden.
    Type of Medium: Online Resource
    ISSN: 0733-4648 , 1552-4523
    URL: Article
    DOI: 10.1177/0733464819901094
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2089028-X
    detail.hit.zdb_id: 155897-3
    SSG: 5,2
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  • 9
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    The Chosen Child: Characteristics of Family Caregivers Selected at an Early Age to Provide Care to Their Parents
    Policy Studies Organization ; 2022
    In:  Journal of Elder Policy Vol. 2, No. 1 ( 2022-05-08)
    Details
    In: Journal of Elder Policy, Policy Studies Organization, Vol. 2, No. 1 ( 2022-05-08)
    Type of Medium: Online Resource
    ISSN: 2767-7451
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18278/jep.2.1
    DOI: 10.18278/jep
    DOI: 10.18278/jep.2.1.2
    Language: Unknown
    Publisher: Policy Studies Organization
    Publication Date: 2022
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  • 10
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    Early Life Predictors of Adult Depression in a Community Cohort of Urban African Americans
    Springer Science and Business Media LLC ; 2013
    In:  Journal of Urban Health Vol. 90, No. 1 ( 2013-2), p. 101-115
    Details
    In: Journal of Urban Health, Springer Science and Business Media LLC, Vol. 90, No. 1 ( 2013-2), p. 101-115
    Type of Medium: Online Resource
    ISSN: 1099-3460 , 1468-2869
    URL: Article
    DOI: 10.1007/s11524-012-9707-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2050322-2
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