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  • 11
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 677-679 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used two catalogues to cover the different periods of time. We searched the catalogue of Chinese earthquakes4 for the period 1900?49 for events preceding and near each earthquake with M 〉 7.0. Since the smallest magnitudes listed are about 4.5, and since they are listed only for the more ...
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  • 12
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 444.2006, 7117, E4-, (1 S.) 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Arising from: D. B. Rowley & B. S. Currie Nature 439, 677–681 (2006); Rowley & Currie reply The determination of palaeo-elevation has emerged in the past 15 years as an important tool for constraining physical ...
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  • 13
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillian Magazines Ltd.
    Nature 410 (2001), S. 891-897 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Around the globe, and in a variety of settings including active and inactive mountain belts, increases in sedimentation rates as well as in grain sizes of sediments were recorded at ∼2–4 Myr ago, implying increased erosion rates. A change in climate represents the only process that ...
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  • 14
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 47-50 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Many human social phenomena, such as cooperation, the growth of settlements, traffic dynamics and pedestrian movement, appear to be accessible to mathematical descriptions that invoke self-organization. Here we develop a model of pedestrian motion to explore the evolution of trails in urban ...
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  • 15
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillian Magazines Ltd.
    Nature 411 (2001), S. 157-162 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Global climate change around 3–4 Myr ago is thought to have influenced the evolution of hominids, via the aridification of Africa, and may have been the precursor to Pleistocene glaciation about 2.75 Myr ago. Most explanations of these climatic events involve changes in ...
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  • 16
    ISSN: 1438-2385
    Keywords: Key words Capsicum annuum ; Carotenoids ; Isolation ; Structure elucidation ; (3S ; 5R ; 8R ; 3′R)-mutatoxanthin ; (3S ; 5R ; 8S ; 3′R)-mutatoxanthin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  (3S,5R,8R,3′R)- and (3S,5R,8S,3′R)-mutatoxanthin were isolated from red spice paprika (Capsicum annuum) and characterized by their UV-VIS, CD, 1H-NMR, 13C-NMR and mass spectra.
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  • 17
    ISSN: 1432-1912
    Keywords: Key words GABAA receptor-ionophore complex ; Dissociation of [35S]TBPS binding ; Barbiturate stereoisomers ; Arrhenius analysis ; Thermodynamics of barbiturate binding ; Electrophysiology of GABAA-ionophores.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The temperature dependence of [35S]-t-butylbicyclophosphorothionate (TBPS) binding to the convulsant sites of the GABAA receptor complex was studied in membrane preparations of rat forebrain. Although specific [35S]TBPS binding was maximal around 20° C, the rate constants of dissociation decreased monotonously between 37° C and 2° C. The displacing potencies of the convulsant S(+) enantiomer of 1-methyl-5-phenyl-5-propyl-barbituric acid (MPPB) (IC50=1250±30 μM) and the depressant R(−) MPPB (IC50=310±5 μM) did not show significant changes between 19° C and 37° C. Therefore barbiturate binding seems to be driven by entropic, rather than enthalpic changes. An excess of MPPB enantiomers elicited accelerated and polyphasic dissociations of [35S]TBPS as compared to the monophasic dissociation by TBPS. Arrhenius analysis was applied to the measurable initial rate constants of dissociation. Arrhenius plots were linear between 2° C and 37° C. Activation parameters were similar when [35S] TBPS dissociation was triggered by the convulsants TBPS and S(+) MPPB. It can be attributed to similar conformations of the closed ionophore complex. In contrast, the depressant R(−) MPPB strongly decreased the activation energy of TBPS dissociation from the open ionophore ternary complex. In whole-cell patch-clamp experiments R(−) MPPB, but not S(+) MPPB, elicited chloride currents in rat primary cortical cultures with an EC50 value of 560±30 μM and a Hill coefficient of 2.9±0.2. These currents were similar to those elicited by GABA and blocked by TBPS. A kinetic scheme is proposed for the dissociation of TBPS and to explain the different effects of MPPB enantiomers. Submillimolar R(−) MPPB is supposed to bind to (about three) barbiturate sites on GABAA-ionophores and to open them in a cooperative manner to result in a decreased activation energy for accelerated displacement of convulsant binding.
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 96 (1998), S. 211-214 
    ISSN: 1432-0533
    Keywords: Key words Congenital myopathy ; Central core ; Nemaline bodies ; Simultaneous occurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is quite rare, that central cores and nemaline bodies occur in the same individual. We describe the case of a 12-year-old girl, who was born with bilateral congenital hip dislocation. Her early motor milestones were delayed. Due to proximal weakness of the lower extremities she has never been able to walk. The family history was negative. Muscle histology, histochemistry and electron microscopic studies showed a central core in nearly all muscle fibers, and nemaline rods in a few. The earlier literature and new genetical findings concerning these mucle abnormalities are also briefly summarized.
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  • 19
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 346 (1990), S. 29-34 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The high altitudes of most mountain ranges have commonly been ascribed to late Cenozoic uplift, without reference to when crustal thickening and other tectonic processes occurred. Deep incision and recent denudation of these mountain ranges, abundant late Cenozoic coarse sediment near them, and ...
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  • 20
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 140-142 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
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