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  • 11
    Electronic Resource
    Electronic Resource
    Book review (1988)
    Springer
    Pure and applied geophysics 127 (1988), S. 161-180 
    Details
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00878697
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  • 12
    Electronic Resource
    Electronic Resource
    Probabilistic aspects of particles transiting a trapping field: an exact combinatorial solution in terms of Gauss polynomials (1985)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 36 (1985), S. 422-432 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Description / Table of Contents: Zusammenfassung Die wahrscheinlichkeitstheoretischen Aspekte einer Reihe von Teilchen, welche ein Feld von Fallen durchlaufen, werden untersucht. Insbesondere wird die Wahrscheinlichkeit, daß dask-te Teilchen absorbiert wird, wenn anfangst Fallen vorhanden waren, mittels kombinatorischer Argumente durch Gauss-Polynome (q-Binomialkoeffizienten) in geschlossener Form dargestellt. Außerdem wird die Überlebenswahrscheinlichkeit desk-ten das Feld durchlaufenden Teilchens errechnet, ebenfalls in Form von Gauss-Polynomen. Die Allgemeinheit der Untersuchung läßt zu, daß die Anzahlt der Fallen eine diskrete Zufallsvariable sein kann, wobei aber die numerischen Berechnungen (in Form von Tabellen) auf deterministischet-Werte beschränkt wurden.
    Notes: Abstract The probabilistic aspects of a queue of particles transiting a trapping field is studied. In particular, the probability that thek-th transiting particle is absorbed, given that there are initiallyt traps, is obtained in closed form by combinatorial arguments in terms of Gauss polynomials (q-binomial coefficients). In addition the probability of survival of thek-th transiting particle is also evaluated, again in terms of Gauss polynomials. The analysis is general enough to allow the number of trapst to be a discrete random variable, although numerical calculations (in the form of tables) are confined tot being deterministic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00944633
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  • 13
    Electronic Resource
    Electronic Resource
    Phase II trial of zeniplatin (CL 286 558), a new patinum compound, in patients with advanced ovarian cancer previously treated with organoplatinum-based therapy (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 234-236 
    Details
    ISSN: 1432-1335
    Keywords: Ovarian cancer ; Cancer chemotherapy ; Platinum drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is a critical need to find new chemotherapeutic agents that are active in platinum-refractory ovarian cancer. A phase II trial of zeniplatin (CL 286 558), a third-generation platinum compound, was conducted in 31 patients with advanced ovarian cancer to examine the safety and activity of the agent when used as a salvage treatment in individuals previously exposed to organoplatinum-based therapy. In general the drug was well tolerated, with moderate emesis and bone marrow suppression being observed in most patients. An unexpected side-effect was significant fever, of unknown etiology, which was noted in 16% of patients. Out of 20 patients, 2 (10%; 95% confidence intervals: 1%–32%) with clinically defined platinum-refractory disease achieved a partial response. Unfortunately, although we have defined definite but modest activity for zeniplatin in platinum-refractory ovarian cancer, further development of this drug has been discontinued because of the severe renal toxicity observed in other clinical trials of this cytotoxic agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01624436
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  • 14
    Electronic Resource
    Electronic Resource
    Diethyldithiocarbamate chemoprotection of carboplatin-induced hematological toxicity (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 360-362 
    Details
    ISSN: 1432-1335
    Keywords: Diethyldithiocarbamate chemoprotection ; Hematological toxicity ; Carboplatin chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelating agent that has been shown to protect against carboplatin-induced bone marrow suppression in animal models. This pilot study was undertaken to evaluate the ability of DDTC to ameliorate the degree and/or duration of myelosuppression from carboplatin chemotherapy in patients with relapsed ovarian cancer. Ten patients who had previously demonstrated a response to platinum-based chemotherapy, were treated with single-agent intravenous carboplatin 400 mg/m2 administered over 30–60 min every 4 weeks. Patients received their first cycle of carboplatin without DDTC, and their second cycle with DDTC. DDTC at 600 mg/m2 was infused over 3 h commencing 30 min prior to carboplatin and was well tolerated. Treatment with DDTC did not decrease the degree of leukopenia or thrombocytopenia associated with carboplatin chemotherapy, nor did it decrease the duration of myelosuppression. This clinical study demonstrates no evidence of a bone-marrow-protective effect for this dose and schedule of DDTC in patients receiving carboplatin chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208846
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  • 15
    Electronic Resource
    Electronic Resource
    Impact of laparotomy finding of significant intraabdominal adhesions on the surgically defined complete response rate to subsequent salvage intraperitoneal chemotherapy (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 163-165 
    Details
    ISSN: 1432-1335
    Keywords: Intraperitoneal therapy ; Ovarian cancer ; Intraabdominal adhesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One possible explanation for the failure of the high concentrations of cytotoxic agents achieved following intraperitoneal (i.p.) drug delivery to produce a favorable response in patients with ovarian cancer is the inability of the drug-containing fluid to be adequately distributed throughout the peritoneal cavity, usually because of intraabdominal adhesion formation. To evaluate the influence of the severity of adhesions, observed at the time of laparotomy performed immediately preceding the initiation of i.p. therapy, on the ability to achieve a surgically defined complete response (S-CR), we retrospectively reviewed the operative reports of 70 patients with small-volume residual ovarian cancer treated on one of three phase-2 salvage i.p. trials at the Memorial Sloan-Kettering Cancer Center. The S-CR rate in the 36 patients withlimited adhesion formation observed upon entering the peritoneal cavity was 28%, compared to 35% in the 34 patients withextensive adhesions (P〉0.05). In 33 patients treated with a phase-2 cisplatin-based i.p. program, who had previously responded to systemic platinum, 47% (8/17) and 44% (7/16) of those with limited and extensive adhesions, respectively, achieved a S-CR (P〉0.05). We conclude that the presence of extensive adhesions observed within the peritoneal cavity at the time of a laparotomy performed immediately prior to the initiation of i.p. therapy does not have a negative impact on the potential to achieve an S-CR, assuming it is technically feasible to lyse all significant adhesions prior to the completion of the operative procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01187507
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  • 16
    Electronic Resource
    Electronic Resource
    Phase 2 trial of chronic low-dose oral etoposide as salvage therapy of platinum-refractory ovarian cancer (1992)
    Springer
    Journal of cancer research and clinical oncology 119 (1992), S. 55-57 
    Details
    ISSN: 1432-1335
    Keywords: Etoposide ; Ovarian cancer ; Cancer chemo ; therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen previously treated patients with advanced ovarian cancer were entered into a phase 2 trial of chronic low-dose oral etoposide (50 mg/day for 20 days, repeated every 28 days) to determine the activity of this therapeutic strategy in organoplatinum-refractory disease. The treatment program was generally well tolerated, with mild neutropenia the most common side-effect encountered. One patient (6%; 95% confidence interval=0–17%) achieved a partial response, which lasted for 11 months. Three additional patients (17%), who failed to meet the criteria of a partial response, demonstrated objective evidence of antineoplastic activity. Chronic low-dose oral etoposide administration is associated with definite, although modest, activity in platinumrefractory ovarian cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209489
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  • 17
    Electronic Resource
    Electronic Resource
    Salvage intraperitoneal therapy of small-volume residual ovarian cancer: impact of pretreatment finding of peritoneal carcinomatosis on the surgical complete response rate (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 235-237 
    Details
    ISSN: 1432-1335
    Keywords: Intraperitoneal chemotherapy ; Cisplatin ; Ovarian cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Second-line intraperitoneal (i.p.) therapy has been demonstrated to result in surgically defined complete responses (S-CR) in 25%–40% of patients with small-volume residual ovarian cancer (microscopic disease or largest tumor mass 〈1 cm in diameter). To evaluate the influence of the surgical finding of diffuse peritoneal carcinomatosis on the S-CR rate to salvage i.p. therapy in this patient population, we retrospectively reviewed the operative reports of 70 patients with small-volume residual ovarian cancer treated on one of three phase-2 second-line i.p. trials at the Memorial Sloan-Kettering Cancer Center. Of the 11 patients with diffuse carcinomatosis, none achieved a S-CR compared to a S-CR rate of 37% (22/59) in patients without this surgical finding (χ2=6.0;P〈0.025). However, of the 7 patients with diffuse carcinomatosis treated on a cisplatin-based i.p. program, the only 2 who had previously responded to systemic platinum also experienced a response (partial) to the i.p. cisplatin regimen. In conclusion, while the surgical finding of diffuse peritoneal carcinomatosis indicates a poor prognosis in patients with small-volume residual ovarian cancer for response to i.p. chemotherapy, patients in this clinical setting with prior evidence of platinum sensitivity may experience some benefit from an i.p. cisplatin-based treatment strategy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410140
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  • 18
    Electronic Resource
    Electronic Resource
    Association between pretreatment CA-125 levels and surgically documented complete responses in patients with ovarian cancer treated with second-line intraperitoneal therapy (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 391-394 
    Details
    ISSN: 1432-1335
    Keywords: Intraperitoneal chemotherapy ; CA-125 ; Ovarian cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Approximately 20%–40% of patients with small-volume residual ovarian cancer, following systemically administered platinum-based chemotherapy, will respond to a second-line intraperitoneal treatment regimen. In an effort to improve the selection criteria for patients being considered for this regional therapeutic approach, we retrospectively evaluated the influence of pretreatment CA-125 levels on the ability of a group of 70 patients with small-volume residual ovarian cancer (no tumor mass〉1 cm in diameter) to achieve a surgically defined complete response (S-CR) following treatment on one of three phase-2 intraperitoneal chemotherapy trials conducted at the Memorial Sloan-Kettering Cancer Center. Overall, 18/46 (39%) patients with normal pretreatment CA-125 levels (≦units/ml) achieved a S-CR, compared to only 4/24 patients (17%) with an elevated pretreatment value (χ2= 3.7, P〉0.5). Despite the lower S-CR rate in patients with elevated CA-125 levels, the duration of response and survival were similar in the two patient populations achieving a S-CR. Thus, we conclude that an elevated pretreatment CA-125 level in a patient with small-volume residual ovarian cancer should not be used by itself to disqualify an individual from consideration for a second-line intraperitoneal treatment regimen, although the finding suggests a reduced likelihood of achieving a S-CR with this therapeutic approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294446
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  • 19
    Electronic Resource
    Electronic Resource
    Characteristic polynomials of chemical graphs via symmetric function theory (1986)
    Springer
    Theoretical chemistry accounts 69 (1986), S. 35-39 
    Details
    ISSN: 1432-2234
    Keywords: Characteristic polynomials ; Chemical graphs ; Symmetric function theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The characteristic polynomial corresponding to the adjacency matrix of a graph is constructed by using the traces of the powers of the adjacency matrix to calculate the coefficients of the characteristic polynomial via Newton's identities connecting the power sum symmetric functions and the elementary symmetric functions of the eigenvalues. It is shown that Frame's method, very recently employed by Balasubramanian, is nothing but symmetric functions and Newton's identities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00526290
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  • 20
    Electronic Resource
    Electronic Resource
    Genetic algebras for tetraploidy with several loci (1980)
    Springer
    Journal of mathematical biology 9 (1980), S. 297-304 
    Details
    ISSN: 1432-1416
    Keywords: Genetic algebra ; Polyploidy ; Tetraploids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The algebra of gamete multiplication corresponding to a population of autotetraploids which differ at n loci, each with an arbitrary number of alleres, is proven to be a genetic algebra, irrespective of the mode of segregation of the n loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276495
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