In:
Annals of the New York Academy of Sciences, Wiley, Vol. 915, No. 1 ( 2000-12), p. 1-14
Abstract:
A bstract : The stomach, duodenum, colon, and pancreas secrete HCO 3 − ions into the lumen. Although the importance of HCO 3 − secretion for the maintenance of mucosal integrity, a normal digestion, and the reabsorption of Cl − has been well established, the molecular nature of the apical and basolateral HCO 3 − transporting proteins has remained largely unknown. Functional studies have suggested that a Na + HCO 3 − cotransport system, similar but not identical to the well‐characterized Na + HCO 3 − cotransporter in the basolateral membrane of the kidney proximal tubule, is present in duodenal and colonic enterocytes, pancreatic ducts cells, and gastric cells and involved in HCO 3 − uptake from the interstitium. This report describes our work towards understanding the molecular nature, cellular origin, and functional relevance of the Na + HCO 3 − cotransporter(s) in the stomach and intestine and reviews work by others on the function and localization of Na + HCO 3 − cotransport processes in the gastrointestinal tract.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2000.915.issue-1
DOI:
10.1111/j.1749-6632.2000.tb05219.x
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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