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  • 1
    Online Resource
    Online Resource
    Persistence of neutral polymorphisms in Lake Victoria cichlid fish
    Proceedings of the National Academy of Sciences ; 1998
    In:  Proceedings of the National Academy of Sciences Vol. 95, No. 24 ( 1998-11-24), p. 14238-14243
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 95, No. 24 ( 1998-11-24), p. 14238-14243
    Abstract: Phylogenetic trees for groups of closely related species often have different topologies, depending on the genes used. One explanation for the discordant topologies is the persistence of polymorphisms through the speciation phase, followed by differential fixation of alleles in the resulting species. The existence of transspecies polymorphisms has been documented for alleles maintained by balancing selection but not for neutral alleles. In the present study, transspecific persistence of neutral polymorphisms was tested in the endemic haplochromine species flock of Lake Victoria cichlid fish. Putative noncoding region polymorphisms were identified at four randomly selected nuclear loci and tested on a collection of 12 Lake Victoria species and their putative riverine ancestors. At all loci, the same polymorphism was found to be present in nearly all the tested species, both lacustrine and riverine. Different polymorphisms at these loci were found in cichlids of other East African lakes (Malawi and Tanganyika). The Lake Victoria polymorphisms must have therefore arisen after the flocks now inhabiting the three great lakes diverged from one another, but before the riverine ancestors of the Lake Victoria flock colonized the Lake. Calculations based on the mtDNA clock suggest that the polymorphisms have persisted for about 1.4 million years. To maintain neutral polymorphisms for such a long time, the population size must have remained large throughout the entire period.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.95.24.14238
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 1998
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    MOLECULAR TRANS-SPECIES POLYMORPHISM
    Annual Reviews ; 1998
    In:  Annual Review of Ecology and Systematics Vol. 29, No. 1 ( 1998-11), p. 1-21
    Details
    In: Annual Review of Ecology and Systematics, Annual Reviews, Vol. 29, No. 1 ( 1998-11), p. 1-21
    Abstract: ▪ Abstract  Trans-species polymorphism (TSP) is the occurrence of similar alleles in related species. Excluding instances in which the similarity arose by convergent evolution, TSP is generated by the passage of alleles from ancestral to descendant species. Closely related, recently diverged species, such as those of the Lake Victoria cichlid flock, may share neutral alleles, but long-lasting TSPs occur only in genetic systems evolving under balancing selection. Two such systems have been studied extensively, the major histocompatibility complex (Mhc) of jawed vertebrates and the self-incompatibility (SI) system of flowering plants. Allelic lineages that diverged many millions of years ago and passed through numerous speciation events have been described in both systems. The lineages may differ at up to 50% of their coding sites, both synonymous and nonsynonymous. The differences arise by the process of incorporation of mutations, which is different from the process of fixation. TSP, on the one hand, complicates phylogenetic analysis, but on the other, it is a useful tool for the study of speciation.
    Type of Medium: Online Resource
    ISSN: 0066-4162
    URL: Issue
    URL: Article
    DOI: 10.1146/ecolsys.1998.29.issue-1
    DOI: 10.1146/annurev.ecolsys.29.1.1
    RVK:
    WA 15000
    Language: English
    Publisher: Annual Reviews
    Publication Date: 1998
    detail.hit.zdb_id: 1474454-5
    detail.hit.zdb_id: 2131893-1
    detail.hit.zdb_id: 2131661-2
    detail.hit.zdb_id: 280090-1
    SSG: 12
    SSG: 14
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  • 3
    Online Resource
    Online Resource
    Novel sites in the p65 subunit of NF‐κB interact with TFIIB to facilitate NF‐κB induced transcription
    Wiley ; 2004
    In:  FEBS Letters Vol. 561, No. 1-3 ( 2004-03-12), p. 217-222
    Details
    In: FEBS Letters, Wiley, Vol. 561, No. 1-3 ( 2004-03-12), p. 217-222
    Abstract: Nuclear factor κB (NF‐κB) transcription factors regulate a large number of genes in response to inflammation, infection and stressful conditions. In this study, we investigated whether NF‐κB p65 regulates the transcription of target genes by interacting with components of the basal transcription machinery. We examined the interaction of p65 with the basal transcription factor IIB (TFIIB). Glutathione S ‐transferase pull down assays showed that the Rel homology domain of p65 is important for binding to TFIIB. Molecular modelling, together with the generation of specific point mutants, revealed that residues 41 R and 42 S in the Rel homology domain of p65 facilitate the interaction with TFIIB. Mutation of these residues showed a decrease in p65 induced transcription, suggesting that they are involved in a functional interaction with TFIIB.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/S0014-5793(04)00157-7
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies
    Springer Science and Business Media LLC ; 2002
    In:  Human Genetics Vol. 110, No. 3 ( 2002-3), p. 209-226
    Details
    In: Human Genetics, Springer Science and Business Media LLC, Vol. 110, No. 3 ( 2002-3), p. 209-226
    Type of Medium: Online Resource
    ISSN: 0340-6717 , 1432-1203
    URL: Article
    DOI: 10.1007/s00439-001-0668-0
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2002
    detail.hit.zdb_id: 1459188-1
    SSG: 12
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