In:
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 309, No. 5 ( 2015-09), p. H977-H985
Abstract:
The consequence of elevated oxidative stress on exercising skeletal muscle blood flow as well as the transport and utilization of O 2 in patients with chronic obstructive pulmonary disease (COPD) is not well understood. The present study examined the impact of an oral antioxidant cocktail (AOC) on leg blood flow (LBF) and O 2 consumption during dynamic exercise in 16 patients with COPD and 16 healthy subjects. Subjects performed submaximal (3, 6, and 9 W) single-leg knee extensor exercise while LBF (Doppler ultrasound), mean arterial blood pressure, leg vascular conductance, arterial O 2 saturation, leg arterial-venous O 2 difference, and leg O 2 consumption (direct Fick) were evaluated under control conditions and after AOC administration. AOC administration increased LBF (3 W: 1,604 ± 100 vs. 1,798 ± 128 ml/min, 6 W: 1,832 ± 109 vs. 1,992 ± 120 ml/min, and 9W: 2,035 ± 114 vs. 2,187 ± 136 ml/min, P 〈 0.05, control vs. AOC, respectively), leg vascular conductance, and leg O 2 consumption (3 W: 173 ± 12 vs. 210 ± 15 ml O 2 /min, 6 W: 217 ± 14 vs. 237 ± 15 ml O 2 /min, and 9 W: 244 ± 16 vs 260 ± 18 ml O 2 /min, P 〈 0.05, control vs. AOC, respectively) during exercise in COPD, whereas no effect was observed in healthy subjects. In addition, the AOC afforded a small, but significant, improvement in arterial O 2 saturation only in patients with COPD. Thus, these data demonstrate a novel beneficial role of AOC administration on exercising LBF, O 2 consumption, and arterial O 2 saturation in patients with COPD, implicating oxidative stress as a potential therapeutic target for impaired exercise capacity in this population.
Type of Medium:
Online Resource
ISSN:
0363-6135
,
1522-1539
DOI:
10.1152/ajpheart.00184.2015
Language:
English
Publisher:
American Physiological Society
Publication Date:
2015
detail.hit.zdb_id:
1477308-9
SSG:
12
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