ISSN:
1432-0428
Keywords:
Key words Non-insulin-dependent diabetes mellitus; microalbuminuria
;
blood pressure
;
monounsaturated fat diet
;
olive oil
;
diet
;
metabolic control.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Previous studies have shown that unsaturated fat-enriched diets may have a beneficial effect on blood pressure in non-insulin-dependent diabetic (NIDDM) patients, whereas little is known about the effects on albuminuria. In a 3-week cross-over design we compared the effects of a currently recommended high-carbohydrate diet (50 % carbohydrate, 30 % fat [10 % monounsaturated fat]) vs a diet rich in monounsaturated fat (30 % carbohydrate, 50 % fat [30 % monounsaturated fat]) on urinary albumin excretion rate, 24-h ambulatory blood pressure and metabolic control in ten NIDDM patients with persistent microalbuminuria. The 24-h ambulatory blood pressure was similar before and after both the high-carbohydrate diet (mean ± SD: 145/78 ± 25/10 vs 143/79 ± 19/10 mmHg (NS) and the monounsaturated fat diet: 140/78 ± 16/8 vs 143/79 ± 15/8 mmHg (NS). No changes were observed in day or night-time blood pressures. Urinary albumin excretion rate was unaffected after 3 weeks' treatment by the diets: from (geometric mean ×/7 tolerance factor) 32.4 ×/72.1 to 36.0 ×/7 1.9 μg/min (NS) vs from 34.2 ×/7 1.9 to 32.1 ×/7 2.1 μg/min (NS). Fasting plasma glucose, serum fructosamine and HbA1c as well as lipid and lipoprotein concentrations were stable during both diets. Compared to the high-carbohydrate diet a reduction in the LDL/HDL cholesterol ratio was observed during the monounsaturated fat diet (p 〈 0.03). In conclusion, compared to a high-carbohydrate diet, 3 weeks' treatment with a monounsaturated fat diet did not affect the levels of 24-h ambulatory blood pressure or albuminuria in microalbuminuric NIDDM patients. Moreover, glycaemic control and lipoprotein levels were unchanged, although a potential beneficial effect on the LDL/HDL-cholesterol ratio was noted. Monounsaturated fat represents an alternative in the diets of NIDDM patients especially when caloric intake is not a concern. [Diabetologia (1995) 38: 1069–1075]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00402177
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