ISSN:
1432-1912
Keywords:
“Depressor Active Substance” (DAS)
;
Vagotonus
;
Pulmonary Vascular Resistance
;
Bronchoconstriction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In stored blood as well as in various organs, a substance appears which causes a marked drop of systemic blood pressure after intravenous injection. The active principle was called “depressor active substance” (DAS). In order to study the circulatory effects of DAS the systemic and the pulmonary vascular resistance (SVR and PVR) and the ventilation volume were measured. DAS stopped respiratory movements by exciting afferent vagus fibres and led to an abnormal cardiac activity and to bronchoconstriction by stimulation of the vagotonus. Furthermore, DAS showed a direct bronchoconstrictor effect. The application of DAS caused a strong increase of PVR. This effect was strong enough to produce an abrupt drop of the systemic blood pressure because of a reduced diastolic filling of the left ventricle. Higher quantities of DAS led to an acute insufficiency of the right ventricle.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00997222
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