GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Nuclear androgen receptors in the prostate of male Praomys (Mastomys) Natalensis (1979)
    Springer
    Urological research 7 (1979), S. 243-247 
    Details
    ISSN: 1434-0879
    Keywords: Prostate ; Androgen receptors ; Mastomys ; dihydrotestosterone ; Nuclear receptor ; Androgen metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The binding of dihydrotestosterone (DHT) within the nuclear fraction of the prostate of male Praomys (Mastomys) Natalensis has been investigated. Using in vivo or in vitro labelling with 3H-DHT, the presence of a receptor protein having a sedimentation coefficient of 3.0 S was demonstrated. The binding was shown to be specific towards DHT and could not be found in control tissue. Analysis of radiometabolites associated with the steroid receptor complex demonstrated that the majority of the bound steroid was DHT. The similarity between this steroid receptor complex and that of rat ventral prostate, together with the potential use of this experimental model are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256601
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Androgen receptors in the prostate of the Rhesus monkey (1977)
    Springer
    Urological research 5 (1977), S. 169-173 
    Details
    ISSN: 1434-0879
    Keywords: Androgen receptors ; Rhesus monkey ; Prostate ; Receptor assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of an androgen receptor protein in the supernatant preparation of the prostate from Rhesus monkey (macaca mulatta) is described. The molecular weight of this receptor protein was found to be 2.8–2.9×105 daltons. The levels of free and bound androgen receptors were measured in the caudal and cranial lobes of the prostate by an exchange assay using methyltrienolone (R1881). The concentration of the free binding sites in the caudal lobe ranged between 3.7–23.7 fmol/mg protein. The value in the cranial lobe was 2.0–7.7 fmol/mg protein. The total binding sites in the caudal lobe ranged between 36.0–112.7 and in the cranial between 21.2–55.0 fmol/mg. The bound receptor ranged between 43.3–109.0 and 19.1–47.3 fmol/mg protein for caudal and cranial lobes respectively. The level of both bound and free receptors was found to be significantly higher in the caudal lobe. This data suggests that the two lobes of the prostate in the Rhesus monkey can be equated with the two zones of the human prostate in respect of androgen responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263733
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A soluble androgen receptor in the cytoplasm of the male mastomys prostate (1978)
    Springer
    Urological research 6 (1978), S. 29-33 
    Details
    ISSN: 1434-0879
    Keywords: Androgen receptor ; Prostate ; Praomys (Mastomys) Natalensis ; Dihydrotestosterone ; Androgen metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A steroid receptor protein was isolated from the cytoplasmic fraction of Mastomys prostate. Following in vivo and in vitro labelling of the tissue with tritiated testosterone or dihydrotestosterone, samples were analysed by gel exclusion chromatography or sucrose density gradient centrifugation. A steroid receptor complex was isolated on Sephadex G-200. Analysis of the steroids associated with this complex showed that the major part of the bound radioactivity was 5 α-dihydrotestosterone. The binding was inhibited by unlabelled testosterone and could not be demonstrated in the liver cytosol. Using sucrose desity gradient centrifugation, the dihydrotestosterone receptor complex sedimented at 5.6 s together with heavier aggregates. In the presence of 0.4 M KCl a single complex was sedimented at 4. 6 s. The results demonstrate a receptor protein in the cytosol of the Mastomys prostate which binds to dihydrotestosterone and is comparable to that of rat prostate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257079
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...