Keywords:
Metals in the body.
;
Metals-Physiological effect.
;
Metal ions.
;
Electronic books.
Description / Table of Contents:
This volume first considers the categories of zinc metalloenzymes, together with models of the enzymic metal-ion binding sites. It covers the nutritional aspects of zinc: its absorption and excretion, its influence on the activity of enzymes and hormones, and the zinc deficiency syndrome.
Type of Medium:
Online Resource
Pages:
1 online resource (521 pages)
Edition:
1st ed.
ISBN:
9781000941395
Series Statement:
Metal Ions in Biological Systems Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=7264510
Language:
English
Note:
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface to the Series -- Preface to Volume 15 -- Contributors -- Contents of Other Volumes -- Chapter 1 Categories of Zinc Metalloenzymes -- 1. Introduction -- 2. Catalytic Role of Zinc: Carbonic Anhydrase -- 3. Structural Role of Zinc: Aspartate Transcarbamylase -- 4. Regulatory and Catalytic Roles of Zinc: Leucine Aminopeptidase -- 5. Noncatalytic and Catalytic Roles of Zinc: Alcohol Dehydrogenase -- 6. General Conclusions -- References -- Chapter 2 Models for Zn(II) Binding Sites in Enzymes -- 1. Introduction -- 2. Carbonic Anhydrase -- 3. Peptidases: Carboxypeptidase and Thermolysin -- 4. Alcohol Dehydrogenase -- 5. Alkaline Phosphatase -- 6. Superoxide Dismutase -- 7. Conclusion -- References -- Chapter 3 An Insight on the Active Site of Zinc Enzymes Through Metal Substitution -- 1. Introduction -- 2. Zinc(II) in Metalloenzymes -- 3. Zinc Substitution and General Remarks on the Metal Derivatives -- 4. Cobalt(II) Derivatives -- 5. Copper(II) Derivatives -- 6. Manganese(II) Derivatives -- 7. Cadmium(II) Derivatives -- 8. Other Metal Derivatives -- 9. Concluding Remarks -- References -- Chapter 4 The Role of Zinc in DNA and RNA Polymerases -- 1. Introduction -- 2. Universal Presence of Zinc in DNA and RNA Polymerases -- 3. DNA Polymerase -- 4. RNA Polymerase -- 5. Possible Role of Intrinsic Zinc -- 6. Conclusions and Perspective -- Abbreviations -- References -- Chapter 5 The Role of Zinc in Snake Toxins -- 1. Introduction -- 2. Metals in Snake Venoms -- 3. Effect of Chelating Agents -- 4. Zinc in Purified Hemorrhagic Toxins and Proteolytic Enzymes -- References -- Chapter 6 Spectroscopic Properties of Metallothionein -- 1. Introduction -- 2. Covalent Structure -- 3. Metal Composition, Removal, and Reconstitution: Preparation of Transition Metal Derivatives.
,
4. Spectroscopic Features of Native and Reconstituted Metallothionein -- 5. Conformation of the Polypeptide Chain in Metallothionein -- 6. Coordination Geometry of Metal-Binding Sites in Metallothionein -- 7. Metal-Thiolate Clusters in Metallothionein -- 8. Stability of Metal-Protein Complexes in Metallothionein -- 9. Conclusion -- References -- Chapter 7 Interaction of Zinc with Erythrocytes -- 1. Introduction -- 2. Interaction of Zinc with Erythrocyte Membranes -- 3. Interaction of Zinc with Hemoglobin -- 4. Conclusion -- Abbreviations -- References -- Chapter 8 Zinc Absorption and Excretion in Relation to Nutrition -- 1. Introduction -- 2. Absorption -- 3. Excretion -- 4. Significance for Zinc Nutrition -- References -- Chapter 9 Nutritional Influence of Zinc on the Activity of Enzymes and Hormones -- 1. Introduction -- 2. Effects of Zinc on Metalloenzyme Activity -- 3. Effects of Zinc on Hormones -- References -- Chapter 10 Zinc Deficiency Syndrome During Parenteral Nutrition in Humans -- 1. Introduction -- 2. Metabolic Aspects of Zinc in Human Nutrition -- 3. Zinc Deficiency During Parenteral Nutrition -- 4. Case Reports -- References -- Author Index -- Subject Index.
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