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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 97 (1998), S. 502-506 
    ISSN: 1432-2242
    Keywords: Key words Additivity ; Diallel cross ; Dominance ; Epistasis ; Wheat ; Yellow rust
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Complete F1 and F2 diallel crosses were used to investigate the inheritance of yellow rust resistance among eight bread wheat lines, developed by CIMMYT for the East African Highlands, which showed a wide response to this disease. Both diallel sets were grown at a site with a high incidence of yellow rust, although for one season, during which the F1 diallel was grown, disease incidence was unusually low. Analyses disclosed the presence of additive, dominance and epistatic effects among those genes controlling rust resistance, with the former being the most important. At normal disease levels, excluding two arrays having resistant common parents removed non-allelic interactions from the F1 diallels. For all F2 diallels, and the remaining F1 diallel, omitting two arrays based on susceptible parents removed these interactions. Local selection of material from a broadly based germplasm appears to be a feasible method of developing adapted cultivars resistant to endemic diseases.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2242
    Keywords: Key words  Triticum aestivum ; Diallel cross ; Parent-offspring regression ; Realized heritability ; Yellow rust ; Yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Several methods are available for estimating heritability in disomic species, including parent-offspring regression, realized heritability, intraclass correlations of recombinant inbred lines, and diallel-cross analysis. Estimates were obtained by these various methods for a set of eight bread wheat (Triticum aestivum) lines adapted to the East African highlands, which had been intercrossed and selfed in a half-diallel arrangement to give F1, F2 and F3 generations, and F6 recombinant inbred lines. Significant genetic variation existed among parents and crosses for both grain yield and yellow rust resistance in all generations. Based on the heritability calculated from the analysis of F6 recombinant inbred lines, analysis of the F2 diallel crosses was recommended for determining the heritability of both characters in early segregating generations. The results also suggest that a form of tandem selection may be effective in developing locally adapted germplasm which combines high grain yield with yellow rust resistance.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 98 (1999), S. 305-309 
    ISSN: 1432-2242
    Keywords: Key words Bread wheat lines ; Coheritability ; Diallel cross ; Direct selection ; Indirect selection ; Yellow rust ; Yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Effectiveness of indirect selection for grain yield was investigated among eight bread wheat lines, selected in a stress environment in the East African Highlands, where they showed a wide response to yellow rust, the biotic factor causing the stress. The lines were intercrossed to give an 8×8F1 diallel, which was grown in this same environment for three consecutive growing seasons during 1994 and 1995. Half of the last trial was sprayed with fungicide. From the estimates of narrow-sense heritabilities for yield and yellow rust severity, and the genetic correlation between them, indirect selection for yield in the unsprayed plots, obtained by choosing the most resistant 5% of this material was, on average, 12% higher than selecting for yield itself. In the fungicide-treated plots, indirect selection was only 73% as efficient as direct selection. The implications of these results for selecting for yield in stress environments are discussed.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-9949
    Keywords: Etidronate ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diphosphonates reduce the rate of bone turnover. They have additional pharmacological properties improving adjuvant arthritis in rats and lowering ESR in this condition. We have evaluated etidronate disodium, a diphosphonate commonly prescribed in the United Kingdom for Paget's disease in patients with rheumatoid arthritis. Apart from an early improvement in articular index, perhaps reflecting anti-inflammatory activity, no significant change occurred in clinical variables or in laboratory indices of ‘secondline’ action at a dose of 5 mg/kg/day.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 7 (1988), S. 237-241 
    ISSN: 1434-9949
    Keywords: Keratoconjunctivitis Sicca ; Sjögren's Syndrome ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The prevalence of keratoconjunctivitis sicca (KCS) was studied in a randomly selected group of 104 patients with rheumatoid arthritis (RA). Symptoms of KCS were noted in 33 patients (31.7%) and they were studied further. After rose bengal staining, 22 of these patients were found to have KCS which was diagnosed by the presence of corneal or conjunctival desiccation. The overall prevalence of KCS was 21.2%. Although an abnormal Schirmer's test was noted in 21 of the 22 patients with KCS, only 8 patients had values of 5 mm or less while the remainder had a mild abnormality ranging from 6 to 15 mm. A reduced marginal tear film was noted in 15 patients (68.2%) with KCS and 13 patients (59%) had a reduced tear break-up time. The Schirmer's test alone is inadequate to make a definite diagnosis of KCS and it is essential to perform slit lamp examination to detect epithelial staining with rose bengal.
    Type of Medium: Electronic Resource
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