ISSN:
1573-6903
Keywords:
Cholinergic neurons
;
neurotoxins
;
retrograde degeneration
;
nucleus basalis
;
Alzheimer's disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Multiple injections of 2 nmols of cyclised ethylcholine mustard aziridinium ion (ECMA), a putative cholinergic neurotoxin, were made (unilaterally) into the cortical terminal field of cholinergic neurons projecting from the nucleus basalis of Meynert (NBM) in the rat basal forebrain. After 30 days, choline acetyltransferase enzymatic activity, a marker for cholinergic function, was significantly lowered in both ipsilateral cortex and NBM, and cholinergic cell bodies in the latter reduced in cross-sectional area, a spectrum of effects characteristic of retrograde degeneration of this pathway. These results are discussed in the context of neurodegenerative diseases affecting cholinergic function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00971009
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