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  • Biochemistry  (1)
  • Immunosuppression and metalloproteinases  (1)
  • 1
    Book
    Book
    Prinzipien der Biochemie (1998)
    Heidelberg : Spektrum, Akad. Verl.
    Details Availability
    Keywords: Biochemistry ; Lehrbuch ; Biochemie ; Biochemie
    Description / Table of Contents: Klappentext: Mit dem "Lehninger" wuchs eine ganze Generation von Studenten auf. Seine außergewöhnliche Klarheit der Darstellung und die gute Lesbarkeit haben Maßstäbe gesetzt. Der Lehninger - der erfolgreiche Lehrbuchklassiker: Umfassend - durch die nahezu lückenlose Darstellung biochemischen Grundwissens Verständlich - durch die außergewöhnliche Klarheit der Sprache und die durchgehend vierfarbige Gestaltung Aktuell - durch vertiefende Exkurse aktueller Themen, in der deutschen Ausgabe nochmals erweitert.
    Type of Medium: Book
    Pages: XLVII, 1223 S. , zahlr. Ill., graph. Darst. , 28 cm
    Edition: 2. Aufl., Studienausg.
    ISBN: 3827403251
    Series Statement: Spektrum Lehrbuch
    Uniform Title: Principles of biochemistry 〈dt.〉
    URL: https://external.dandelon.com/download/attachments/dandelon/ids/DE00411079368ADF309AEC125775900449A81.pdf
    RVK:
    WD 4000
    RVK:
    WD 4010
    Language: German
    Note: Literaturangaben , Literaturangaben
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of immunosuppressive drugs on the release of metalloproteinases from human polymorphonuclear leukocytes (1991)
    Springer
    Transplant international 4 (1991), S. 26-30 
    Details
    ISSN: 1432-2277
    Keywords: Immunosuppression and metalloproteinases ; Metalloproteinases and immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concentration of the metalloproteinases type I collagenase and gelatinase was measured in isolated polymorphonuclear leukocytes (PMNLs) of renal transplant recipients treated either with cyclosporin A (CyA) and prednisolone (Pr) (n=8) or azathioprine (Aza) and Pr (n=8), and of healthy subjects (n=12). PMNLs of CyA- and Aza-treated transplant patients displayed markedly higher gelatinase content (2427±489 and 3284±357 ng/107 cells) than PMNLs of controls (528±83 ng/107 cells). There was also a higher content of type I collagenase in PMNLs (3374±292 ng/107 cells) of Aza-treated patients and significantly elevated levels in PMNLs of patients receiving CyA (3625±229 ng/107 cells) compared with healthy subjects (2878±151 ng/107 cells). In contrast, neutrophil lactoferrin content was lower in transplant patients. Thus, immunosuppressive drugs may reduce the release of leukocyte proteinases, which are known for their deleterious role in proteolytic tissue and matrix breakdown. In vitro, the effects of different immunosuppressive drugs on the release of lactoferrin, collagenase and gelatinase were investigated on FMLPNTL-stimulated PMNLs isolated from healthy subjects. CyA but not Aza or Pr caused inhibition of gelatinase, collagenase and lactoferrin release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335512
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