ISSN:
1432-072X
Keywords:
Methanobacterium
;
Methanosarcina barkeri
;
Methanospirillum hungatii
;
Cell wall
;
Pseudomurein
;
Sensitivity
;
Antibiotics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The sensitivity to inhibitors of various steps of murein synthesis was studied with six strains of methanogenic bacteria. Four of the strains belong to the genus Methanobacterium, which contains pseudomurein in its cell walls. This polymer-as well as murein-is not present in the two control organisms, Methanosarcina barkeri and Methanospirillum hungatii, which were found to be resistant to all inhibitors of murein synthesis. The four strains of Methanobacterium were resistant to the antibiotics fosfomycin, D-cycloserine, vancomycin, penicillin G and cephalosporin C, all of which inhibit the synthesis or function of the peptide subunits of murein. On the other hand, the four strains were susceptible to bacitracin, nisin, gardimycin and enduracidin. It is therefore assumed that the biosynthesis of murein and pseudomurein, respectively, may have some reactions of the so-called lipid cycle and the polymerization of the heteroglycan strands in common.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00406661
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