GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2016-01-15
    Description: Helminth parasitic infections are a major global health and social burden. The host defence against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell-mediated immunity. Induction of type 2 cytokines, including interleukins (IL) IL-4 and IL-13, induce goblet cell hyperplasia with mucus production, ultimately resulting in worm expulsion. However, the mechanisms underlying the initiation of type 2 responses remain incompletely understood. Here we show that tuft cells, a rare epithelial cell type in the steady-state intestinal epithelium, are responsible for initiating type 2 responses to parasites by a cytokine-mediated cellular relay. Tuft cells have a Th2-related gene expression signature and we demonstrate that they undergo a rapid and extensive IL-4Ralpha-dependent amplification following infection with helminth parasites, owing to direct differentiation of epithelial crypt progenitor cells. We find that the Pou2f3 gene is essential for tuft cell specification. Pou2f3(-/-) mice lack intestinal tuft cells and have defective mucosal type 2 responses to helminth infection; goblet cell hyperplasia is abrogated and worm expulsion is compromised. Notably, IL-4Ralpha signalling is sufficient to induce expansion of the tuft cell lineage, and ectopic stimulation of this signalling cascade obviates the need for tuft cells in the epithelial cell remodelling of the intestine. Moreover, tuft cells secrete IL-25, thereby regulating type 2 immune responses. Our data reveal a novel function of intestinal epithelial tuft cells and demonstrate a cellular relay required for initiating mucosal type 2 immunity to helminth infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gerbe, Francois -- Sidot, Emmanuelle -- Smyth, Danielle J -- Ohmoto, Makoto -- Matsumoto, Ichiro -- Dardalhon, Valerie -- Cesses, Pierre -- Garnier, Laure -- Pouzolles, Marie -- Brulin, Benedicte -- Bruschi, Marco -- Harcus, Yvonne -- Zimmermann, Valerie S -- Taylor, Naomi -- Maizels, Rick M -- Jay, Philippe -- 106122/Wellcome Trust/United Kingdom -- P30DC011735/DC/NIDCD NIH HHS/ -- England -- Nature. 2016 Jan 14;529(7585):226-30. doi: 10.1038/nature16527.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS, UMR-5203, Institut de Genomique Fonctionnelle, F-34094 Montpellier, France. ; INSERM, U1191, F-34094 Montpellier, France. ; Universite de Montpellier, F-34000 Montpellier, France. ; Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, UK. ; Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA. ; Institut de Genetique Moleculaire de Montpellier, CNRS, UMR5535, F-34293 Montpellier, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26762460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Lineage ; Cell Proliferation ; Feedback, Physiological ; Female ; Goblet Cells/cytology/immunology ; Immunity, Mucosal/*immunology ; Interleukin-13/immunology ; Interleukin-17/immunology/metabolism ; Intestinal Mucosa/*cytology/*immunology/metabolism ; Male ; Mice ; Nippostrongylus/*immunology ; Octamer Transcription Factors/deficiency ; Parasites/*immunology ; Receptors, Interleukin-4/immunology ; Signal Transduction/immunology ; Stem Cells/cytology/immunology ; Strongylida Infections/immunology ; Th2 Cells/cytology/immunology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2012-01-17
    Description: The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active signal is its ectodomain, which is shed from cells after cleavage by an ADAM family metalloprotease, ADAM17 (TNFalpha-converting enzyme, TACE). We report that iRhom2 (RHBDF2), a proteolytically inactive member of the rhomboid family, is required for TNF release in mice. iRhom2 binds TACE and promotes its exit from the endoplasmic reticulum. The failure of TACE to exit the endoplasmic reticulum in the absence of iRhom2 prevents the furin-mediated maturation and trafficking of TACE to the cell surface, the site of TNF cleavage. Given the role of TNF in autoimmune and inflammatory diseases, iRhom2 may represent an attractive therapeutic target.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272371/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272371/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adrain, Colin -- Zettl, Markus -- Christova, Yonka -- Taylor, Neil -- Freeman, Matthew -- MC_U105178780/Medical Research Council/United Kingdom -- U.1051.01.009(78780)/Medical Research Council/United Kingdom -- U105178780/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 13;335(6065):225-8. doi: 10.1126/science.1214400.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22246777" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins/*metabolism ; Animals ; Carrier Proteins/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Enzyme Activation ; Furin/metabolism ; Humans ; Lipopolysaccharides/immunology ; Macrophages/metabolism ; Mice ; Mice, Knockout ; Protein Binding ; Protein Transport ; *Signal Transduction ; Tumor Necrosis Factor-alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2015-05-23
    Description: Human evolutionary scholars have long supposed that the earliest stone tools were made by the genus Homo and that this technological development was directly linked to climate change and the spread of savannah grasslands. New fieldwork in West Turkana, Kenya, has identified evidence of much earlier hominin technological behaviour. We report the discovery of Lomekwi 3, a 3.3-million-year-old archaeological site where in situ stone artefacts occur in spatiotemporal association with Pliocene hominin fossils in a wooded palaeoenvironment. The Lomekwi 3 knappers, with a developing understanding of stone's fracture properties, combined core reduction with battering activities. Given the implications of the Lomekwi 3 assemblage for models aiming to converge environmental change, hominin evolution and technological origins, we propose for it the name 'Lomekwian', which predates the Oldowan by 700,000 years and marks a new beginning to the known archaeological record.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harmand, Sonia -- Lewis, Jason E -- Feibel, Craig S -- Lepre, Christopher J -- Prat, Sandrine -- Lenoble, Arnaud -- Boes, Xavier -- Quinn, Rhonda L -- Brenet, Michel -- Arroyo, Adrian -- Taylor, Nicholas -- Clement, Sophie -- Daver, Guillaume -- Brugal, Jean-Philip -- Leakey, Louise -- Mortlock, Richard A -- Wright, James D -- Lokorodi, Sammy -- Kirwa, Christopher -- Kent, Dennis V -- Roche, Helene -- England -- Nature. 2015 May 21;521(7552):310-5. doi: 10.1038/nature14464.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA [2] CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France [3] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA [2] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [3] Department of Anthropology and Center for Human Evolutionary Studies, Rutgers University, New Brunswick, New Jersey 08901, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Anthropology and Center for Human Evolutionary Studies, Rutgers University, New Brunswick, New Jersey 08901, USA [3] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [3] Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] CNRS, UPR 2147, Dynamique de l'Evolution Humaine, 44 rue de l'Amiral Mouchez, 75014 Paris, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] CNRS, UMR 5199 PACEA, Universite de Bordeaux, 33615 Pessac, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [3] Department of Sociology, Anthropology and Social Work, Seton Hall University, South Orange, New Jersey 07079, USA. ; 1] CNRS, UMR 5199 PACEA, Universite de Bordeaux, 33615 Pessac, France [2] Inrap, Centre Mixte de Recherche Archeologique, Domaine de Campagne, 24620 Campagne, France. ; CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France. ; 1] CNRS, UMR 7055, Prehistoire et Technologie, Universite Paris Ouest Nanterre La Defense, 21 allee de l'Universite, 92023 Nanterre Cedex, France [2] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Inrap, 34-36 avenue Paul-Vaillant Couturier, 93120 La Courneuve, France. ; IPHEP, Institut de Paleoprimatologie, Paleontologie Humaine: Evolution et Paleoenvironnements, CNRS, UMR 7262, Universite de Poitiers, Bat. B35 - TSA 51106, 6 rue Michel Brunet, 86073 Poitiers Cedex 9, France. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] Aix-Marseille Universite, CNRS, MCC, UMR 7269, LAMPEA, 13094 Aix-en-Provence Cedex 2, France. ; Turkana Basin Institute, Stony Brook University, Stony Brook, New York 11794-4364, USA. ; Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA. ; West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya. ; 1] West Turkana Archaeological Project, P.O. Box 40658-00100, Ngara Rd, Nairobi, Kenya [2] National Museums of Kenya, Department of Earth Sciences, Archaeology Section, P.O. Box 40658-00100 Ngara Rd, Nairobi, Kenya. ; 1] Department of Earth and Planetary Sciences, Rutgers University, Piscataway, New Jersey 08854, USA [2] Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25993961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeology ; Biological Evolution ; Environment ; Fossils ; History, Ancient ; *Hominidae ; Kenya ; Paleontology ; Technology/history ; Time Factors ; *Tool Use Behavior
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...