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  • 1
    Electronic Resource
    Electronic Resource
    Fructosamine in relation to maternofetal glucose and insulin homeostasis in gestational diabetes (1990)
    Springer
    Archives of gynecology and obstetrics 247 (1990), S. 173-185 
    Details
    ISSN: 1432-0711
    Keywords: Gestational diabetes ; Oral glucose tolerance test ; HbA1c ; Fructosamine ; Amniotic fluid insulin ; Screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The problem in screening for gestational diabetes is recognizing fetuses endangered by hyperinsulinism. 21.8% of patients with gestational diabetes (defined as a glucose peak exceeding 160 mg/dl after an oral glucose load of 1 g per kg body weight) develop fetal hyperinsulinism. Thus, is indicated by an elevated amniotic fluid insulin (AFI) concentration and requires insulin treatment. Since fetal hyperinsulinism can be neither predicted nor ruled out by single parameters of materal metabolism, every patient with gestational diabetes had to undergo amniocentesis for amniotic fluid analysis. In 110 gestational diabetics and 822 controls, fetal hyperinsulinism was predicted by the combination of the oGTT (≥160 mg/dl) and maternal serum fructosamine (≥2.6 mmol/l) with a sensitivity of 95.8% and a specificity of 91.8%. Thus, 73% of gestational diabetics need not undergo amniocentesis. With a sensitivity of 20.8%, the combination of the oGTT and HbA1c is not useful in identifying hyperinsulinemic fetuses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389542
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maternal serum fructosamine and maternofetal glucose and insulin homeostasis in normal pregnancy (1990)
    Springer
    Archives of gynecology and obstetrics 248 (1990), S. 1-11 
    Details
    ISSN: 1432-0711
    Keywords: Gestational diabetes ; Oral glucose tolerance test ; Fructosamine ; HbA1c ; Amniotic fluid insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Well-defined normal values are necessary to identify pregnancies complicated by gestational diabetes (GD) and thus further reduce perinatal morbidity and mortality from this condition. The present study defined the range for the oral glucose tolerance test (oGTT) in 2578 pregnancies. After exclusion of abnormal results 822 randomized patients were used to define normal values for fructosamine, HbA1c, insulin, glucose and C-peptide in the maternal serum; insulin, glucose and fructosamine in the amniotic fluid; and insulin, glucose, C-peptide and fructosamine in the cord blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389583
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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