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  • 1
    Electronic Resource
    Electronic Resource
    The origin of equine endometrial cups. III. Light and electron microscopic study of fully developed equine endometrial cups (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 177 (1973), S. 503-517 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Equine endometrial cups are localized endometrial outgrowths which develop in mares during early pregnancy and secrete pregnant mares serum gonadotrophin (PMSG).The principal cell-type found in endometrial cups is large, regular and epithelioid in appearance. These cup cells have one or two large euchromatic nuclei with dense, characteristic nucleoli. Their cytoplasm is filled with irregular profiles of endoplasmic reticulum containing pale flocculent material. Lipid droplets and a few mitochondria are also present. Golgi material is not prominent and the absence of membrane-bound secretory granules suggest that the Golgi apparatus does not package a secretory product. The plasmalemma is mostly smooth in outline but is modified in some places to form short microvilli or complex intercrescent folds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091770404
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  • 2
    Electronic Resource
    Electronic Resource
    The origin of equine endometrial cups. II. Invasion of the endometrium by trophoblast (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 177 (1973), S. 485-501 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Light and electron microscopic examination of tissues fixed in situ by perfusion of the gravid horn of the uteri of mares between 36 and 38 days of gestation revealed that the equine endometrial cups are composed of trophoblast cells which originate from the discrete annulate portion of the foetal membranes known as the chorionic girdle. This structure consists of closely opposed villous projections of elongated trophoblast cells and it becomes firmly attached to the endometrium around the thirty-sixth day of pregnancy. The specialized girdle cells invade and phagocytose the endometrial epithelium and then migrate through the basal lamina into the endometrial stroma where they develop into endometrial cup cells.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091770403
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  • 3
    Electronic Resource
    Electronic Resource
    Gross and histological variations along the length of the rat vas deferensResearch supported USPHS Grant HD-04290. (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 190 (1978), S. 795-809 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The gross morphology of the vas deferens of the rat and the changes that occur along its length are reported. It is shown that the organ can be divided into proximal, distal and terminal portions. Each portion is histologically unique and is situated in a different part of the body. The differences are discussed in relation to the function of the organ and their possible role in the consequences of vasectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091900403
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  • 4
    Electronic Resource
    Electronic Resource
    Editorial (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Advanced Materials for Optics and Electronics 2 (1993), S. 105-105 
    Details
    ISSN: 1057-9257
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/amo.860020302
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  • 5
    Electronic Resource
    Electronic Resource
    Characterization of ZnS grown by metal-organic chemical vapour deposition on GaAs(100) using t-butyl mercaptan and dimethylzinc (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Advanced Materials for Optics and Electronics 1 (1992), S. 43-46 
    Details
    ISSN: 1057-9257
    Keywords: Zinc sulphide ; MOCVD growth ; t-Butyl mercaptan ; Dimethylzinc ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: ZnS has been grown on GaAs(100) substrates by atmospheric pressure metal-organic chemical vapour deposition (MOCVD) using dimethylzinc (DMZn) and t-butyl mercaptan (t-BuSH). The effects of the reactant gas phase molar ratio and the growth temperature on the characteristics of the material grown have been investigated. The structural quality of the layer is demonstrated by X-ray rocking curve half-widths of less than 300 arcsec for the epilayers. There is little significant pre-reaction and the layers are of excellent surface morphology and layer uniformity.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/amo.860010108
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  • 6
    Electronic Resource
    Electronic Resource
    Observations on destruction of spermatozoa in the cauda epididymidis and proximal vas deferens of non-seasonal male mammalsSupported by USPHS Grant HD-04290. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 149 (1977), S. 93-109 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The electron microscope has been used to examine luminal spermatozoa from the cauda epididymidis and proximal vas deferens of rats, mice, hamsters and guinea pigs. Free in the lumen of all species are accumulations of a dense material within which are vesicles, granules and dense bodies, as well as spermatozoa. The spermatozoa are undergoing a process of degeneration as judged by a loss of plasma membrane from both heads and tails and further disruption of acrosomal membranes, mitochondrial sheaths and outer dense fibers. Disruption of spermatozoa also occurs outside these obvious dense masses when the luminal protein precipitated by the fixation procedure has contact with the spermatozoon. Intact spermatozoa are separated from luminal material by a clear “halo”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001490107
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  • 7
    Electronic Resource
    Electronic Resource
    Phagocytosis of spermatozoa in the terminal region and gland of the vas deferens of the ratResearch supported by USPHS Grant HD-04290. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 150 (1977), S. 247-267 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The existence of a discrete group of cells that are able to phagocytose spermatozoa is reported in the terminal vas deferens of the rat. In addition it is shown that phagocytosis of spermatozoa occurs in the gland of the vas deferens. The cytological mechanisms involved in the phagocytotic process are discussed, and the role that this activity may have on the removal of surplus spermatozoa is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001500204
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  • 8
    Electronic Resource
    Electronic Resource
    Morphology of the epithelium of the extratesticular rete testis, ductuli efferentes and ductus epididymidis of the adult male rabbitResearch supported by USPHS Grants HD-04290 (DWH) and HD-02344 (DWF), by the Ford Foundation (DWF) and by a Milton Fund grant from Harvard University (DWH). (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 156 (1979), S. 373-400 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The fine structure of the epithelium lining the extratesticular rete testis, ductuli efferentes and ductus epididymidis of the rabbit has been investigated. In the ductuli efferentes the epithelium is composed of two cell types, principal cells and ciliated cells. The latter cell type is distinguished from principal cells by the presence of cilia projecting into the lumen and the position of the nucleus in the apical half of the cell. Principal cells in this segment are characterized by micropinocytotic vesicles on the surface plasma membrane and a variety of small dense bodies scattered throughout the cytoplasm. In the ductus epididymidis basal cells replace ciliated cells as the second cell type, but differences between various segments of the epididymis are related to the fine structure of the principal cells. In the proximal caput epididymidis (Nicander's region 1) the principal cells are tall with long microvilli. They typically contain a small Golgi apparatus and a cluster of dense bodies adjacent to the nucleus. In the distal caput epididymidis (Nicander's regions 2-5) the apical cytoplasm of principal cells is filled with numerous micropinocytotic vesicles and large multivesicular bodies; these features are interpreted as signs of absorptive activity. The multivesicular bodies are absent from the cytoplasm of principal cells in the corpus epididymidis (Nicander's region 6) and, instead, numerous elements of smooth endoplasmic reticulum, a large Golgi apparatus, lipid droplets and dense bodies characterize principal cells in this segment. Towards the proximal cauda epididymidis (Nicander's region 7), the number of dense bodies (lysosomes) in the cytoplasm increases considerably. In the globose cauda (Nicander's region 8), the principal cells are reduced in height, and in addition to the features described in region 7, are characterized by a concentric array of rough endoplasmic reticulum in the basal cytoplasm. These observations are discussed in relation to the role of the epididymis in promoting the maturation and survival of spermatozoa.
    Additional Material: 28 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001560307
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  • 9
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    Psoriasis treatment and management - a systematic review of full economic evaluations (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-10-17
    Description: Psoriasis frequently requires lifetime control and current therapies vary significantly in price. High quality economic evaluations are necessary to determine if higher cost treatments are value for money. This review aims to: identify the cost-effectiveness of psoriasis care (whether more expensive interventions are associated with savings in health care and psoriasis management and/or improve patients’ health); assess the level of uncertainty and transferability of this evidence to policy and practice and; identify future research needs. Searches of electronic databases EMBASE, MEDLINE and NHS EED for full economic evaluations were conducted in January 2012 (updated April 2014). Included articles were screened, selected and critically appraised using pre-defined inclusion criteria and data extraction forms.1,355 articles were identified; 37 papers reporting 71 comparisons met the inclusion criteria. Treatments evaluated were systemic (n=45), topical (n=22), phototherapies (n=14) and combination (n=4). Despite a significant number of recent economic evaluations, the cost-effectiveness of all therapies remains unclear. This reflects diversity in settings, perspective and design. Economic evaluations were constrained by limited availability of high quality short and long term head-to-head comparisons of the effectiveness, safety and adherence of different interventions. This means the economic evidence is dominated by comparisons of interventions to placebo, with implicit comparisons of different therapies. There is a lack of evaluations of service model innovations to deliver complex packages of care for psoriasis. Primary and secondary integrated clinical and economic research is needed to address the limitations and to identify patient preferences and barriers/facilitators to treatment. This article is protected by copyright. All rights reserved.
    Print ISSN: 0007-0963
    Electronic ISSN: 1365-2133
    Topics: Medicine
    Published by Wiley-Blackwell
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