In:
European Journal of Haematology, Wiley, Vol. 99, No. 3 ( 2017-09), p. 249-254
Abstract:
The role of PAI ‐1 4G/5G polymorphism in venous thrombosis has been contradictory. PAI ‐1 4G/4G genotype is associated with elevated levels of PAI ‐1 resulting in a hypofibrinolytic state and a higher thrombotic risk. Objective In this study, the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism of PAI ‐1 gene in Indian patients with different types of venous thrombosis was investigated for its role in development of thrombosis. Method A total of 87 portal vein thrombosis ( PVT ), 71 Budd‐Chiari syndrome ( BCS ), 156 cerebral vein thrombosis ( CVT ), and 163 deep vein thrombosis ( DVT ) patients were studied alongside 251 healthy controls for the PAI ‐1 4G/5G polymorphism by allele‐specific PCR . Results Frequency of 4G/4G genotype was higher in all groups in comparison with controls. 4G/4G was associated with PVT risk ( OR =2.51, 95% CI =1.29‐4.96, P =.0075), BCS risk ( OR =5.98, 95% CI =2.68‐13.42, P 〈 .0001), and DVT risk ( OR =1.75, 95% CI =0.98‐3.02, P =.0225). This is the first case‐control study from India establishing PAI ‐1 4G/4G as a strong risk factor for abdominal thrombosis ( PVT and BCS ). Statistically significant association was not found between 4G/4G genotype and CVT risk. Conclusion PAI ‐1 4G/4G is a strong risk factor for venous thrombosis in Indian patients and should be included in laboratory testing panel of thrombophilia.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2017.99.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027114-1
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