In:
Colorectal Disease, Wiley, Vol. 24, No. 9 ( 2022-09), p. 1054-1062
Abstract:
The aim of this study was to investigate whether the application of nanofat containing stem cells improves continence in women who had previously undergone anal sphincteroplasty with unsatisfactory long‐term outcomes. Method This prospective pilot study included nine women with various degrees of anal incontinence who had previously undergone anal sphincteroplasty due to obstetric trauma. In all patients, the Wexner Incontinence Score ( WS ) and Faecal Incontinence Quality of Life Score ( FIQLS ), as well as anal manometry and endoanal ultrasound measurements, were performed before the procedure and during follow‐up. In all patients, liposuction was performed and 50 ml of raw lipoaspirate was obtained and processed using a NanoFat Kit device. Approximately 20 ml of the mechanically emulsified and filtrated fat was obtained and the anal sphincter complex was infiltrated with it. Patient follow‐up was conducted in person or via telephone 6 and 12 months after the procedure. Results The squeeze pressure was significantly increased 6 months after the procedure ( p = 0.01). The external anal sphincter measured at the 12 o'clock position was significantly thicker ( p = 0.04). A significant decrease in the WS was observed both 6 and 12 months after the procedure compared with baseline values ( p 〈 0.05 for both). Conclusion This study is the first to show that the application of nanofat as an injectable product improves continence in patients with unsatisfactory results after sphincteroplasty, suggesting it to be a promising and effective therapeutic tool. The procedure is safe and can be easily performed as an ambulatory procedure.
Type of Medium:
Online Resource
ISSN:
1462-8910
,
1463-1318
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2004820-8
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