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  • Wiley  (31)
  • 1
    Online Resource
    Online Resource
    Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC
    Wiley ; 2023
    In:  Clinical and Translational Medicine Vol. 13, No. 11 ( 2023-11)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 13, No. 11 ( 2023-11)
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v13.11
    DOI: 10.1002/ctm2.1454
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2697013-2
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  • 2
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    Online Resource
    Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus ‐induced mastitis
    Wiley ; 2022
    In:  BioFactors Vol. 48, No. 1 ( 2022-01), p. 148-163
    Details
    In: BioFactors, Wiley, Vol. 48, No. 1 ( 2022-01), p. 148-163
    Abstract: Although the specific expression of long noncoding RNA (lncRNA) in mastitis tissue has been reported, few studies have involved the differential expression of lncRNA in mastitis exosomes (Exo) and its mechanism and function. We screened an lncRNA associated with FAS translational regulation (lnc‐AFTR) through exosomal RNA sequencing, and clarified its function and molecular mechanism. Lnc‐AFTR is markedly downregulated in Staphylococcus aureus ‐Exo and S. aureus ‐induced MAC‐T cell as well as mastitis tissue. Overexpression of lnc‐AFTR exosomes (oe‐AFTR‐Exo) significantly improves cell damage induced by S. aureus , including inhibiting apoptosis, promoting proliferation, and increasing the production of pro‐inflammatory cytokines (tumor necrosis factor‐α [TNF‐α] and interleukin‐1β [IL‐1β] ). Oe‐AFTR‐Exo also suppressed the activation of Caspase‐8, Caspase‐3, and JNK. Dual‐luciferase report analysis confirmed that lnc‐AFTR interacts with FAS mRNA directly to hinder translation process, but does not degrade FAS mRNA. Overexpression of lnc‐AFTR in MAC‐T cells obviously reduced S. aureus ‐induced apoptosis and inflammation. Knockdown of lnc‐AFTR significantly increased FAS and promoted the activation of Caspase‐8, Caspase‐3, and JNK caused by S. aureus . In summary, these results revealed the mechanism by which lnc‐AFTR directly bound FAS mRNA to prevent translation, and confirmed that the exosomal lnc‐AFTR exerted anti‐inflammatory and anti‐apoptotic effects by inhibiting the activation of TNF signaling pathway and mitogen‐activated protein kinases (MAPK) signaling pathway.
    Type of Medium: Online Resource
    ISSN: 0951-6433 , 1872-8081
    URL: Issue
    URL: Article
    DOI: 10.1002/biof.v48.1
    DOI: 10.1002/biof.1806
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2011592-1
    SSG: 12
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  • 3
    Online Resource
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    Determination of glycosylation degree for glycoconjugate vaccines using a solid‐phase extraction combined with liquid chromatography and tandem mass spectrometry method
    Wiley ; 2020
    In:  Journal of Separation Science Vol. 43, No. 14 ( 2020-07), p. 2880-2888
    Details
    In: Journal of Separation Science, Wiley, Vol. 43, No. 14 ( 2020-07), p. 2880-2888
    Abstract: In this study, a solid‐phase extraction with liquid chromatography and tandem mass spectrometry method was developed to determine the degree of glycosylation of glycosylation sites and the ratio of free carrier protein to total carrier protein for glycoconjugate vaccines. To remove and enrich the glycosylated peptides, a solid‐phase extraction method was developed, optimized, and hyphenated to liquid chromatography−tandem mass spectrometry. The developed solid‐phase extraction with liquid chromatography−tandem mass spectrometry method was shown to possess a wide linear dynamic range (0.03−100 μg/mL), a high sensitivity (0.03 μg/mL for CRM197), good interday and intra‐day precision (relative standard deviation of peak area  〈  3.3%), and good recoveries from vaccine matrix (90−105%). Finally, the method was utilized to determine the degree of glycosylation and free carrier protein to total carrier protein ratio for pneumococcal conjugate vaccines and meningococcal vaccines. For quality evaluation of glycoconjugate vaccines, the method could provide more information than the traditional size exclusion chromatography method. Fourteen and twelve reported glycosylation sites for CRM197‐ and tetanus toxin‐based vaccines can be detected, respectively.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v43.14
    DOI: 10.1002/jssc.202000075
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2047990-6
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  • 4
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    Online Resource
    Profile, treatment patterns, and influencing factors of anthracycline use in breast cancer patients in China: A nation‐wide multicenter study
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 19 ( 2021-10), p. 6744-6761
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 19 ( 2021-10), p. 6744-6761
    Abstract: Anthracycline‐based chemotherapy (ABC) is one of the standard therapies against breast cancer. However, few guidelines are currently available to optimize the use of ABC. Therefore, the present analysis aimed at determining the profile and treatment patterns of ABC and the association of clinicopathological characteristics with ABC selection. Methods We retrospectively analyzed the data of a nation‐wide multicenter epidemiological study, which collected the medical records of breast cancer patients receiving chemotherapy in different settings from seven geographic regions in China (NCT03047889). Results In total, 3393 patients were included, with 2917 treated with ABC. Among them, 553 (89.8%), 2165 (81.7%), and 814 (25.7%) were subjected to ABC as neoadjuvant, adjuvant, and advanced chemotherapy, respectively. The most frequently used regimens were anthracycline‐taxane‐based combinations for neo‐ and adjuvant chemotherapy, along with taxanes and oral fluorouracils for the palliative stages. In the overall cohort, patients aged 〈 40 or 40‐65 ( p 〈 0.001), in premenopause ( p 〈 0.001), without comorbidities ( p = 0.016), with invasive ductal carcinoma ( p = 0.001), high lymph node involvement ( p 〈 0.001), in the pTNM stage II, III, or IV versus stage I ( p 〈 0.001), subjected to mastectomy ( p 〈 0.001) or subjected to sentinel lymph node biopsy combined with axillary lymph node dissection ( p = 0.044), or with a decreased disease‐free survival ( p 〈 0.001) were more likely to be recommended to ABC. Conclusion Taken together, ABC remained the mainstay of breast cancer treatment, especially in neo and adjuvant therapy. ABC was mainly used as a combination therapy, and the correlation between influencing factors and ABC choice varied during different settings, indicating the preference and different perspectives of medication considered by medical oncologists regarding the use ABC in China.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.19
    DOI: 10.1002/cam4.4215
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 5
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    Online Resource
    Organic Additive Assisted Ordered Mesoporous Ni/Al 2 O 3 Catalyst for CO 2 Methanation
    Wiley ; 2020
    In:  ChemistrySelect Vol. 5, No. 16 ( 2020-04-30), p. 4913-4919
    Details
    In: ChemistrySelect, Wiley, Vol. 5, No. 16 ( 2020-04-30), p. 4913-4919
    Abstract: A trimethylbenzene (TMB) assisted ordered mesoporous Ni/Al 2 O 3 catalysts were prepared by a one‐pot evaporation‐induced self‐assembly (EISA) method for CO 2 methanation to solve the problems of high‐temperature sintering of Ni particle and poor low‐temperature activity of Ni‐based catalysts. For comparison, we also prepared the catalysts without TMB or with different amount of NiO loadings. These samples were characterized by nitrogen adsorption, X‐ray diffraction, H 2 temperature programmed reduction, scanning electron microscopy and transmission electron microscopy. The structure of the ordered mesoporous Ni/Al 2 O 3 catalyst was modified by TMB to obtain a high specific surface area and a smaller pore size, resulting in the smaller Ni particles size and the higher metal dispersion. These changes could increase the interaction between the Ni species and the support, which effectively solved the problem of high temperature Ni sintering and low temperature activity. The mesoporous TMB‐assisted ordered mesoporous Ni/Al 2 O 3 catalysts catalyst reached the maximum CO 2 conversion and CH 4 yield of 74.61 and 88.27 %, respectively at 425 °C, 0.1 MPa and a weight hourly space velocity of 60,000 mL g −1  h −1 . In addition, the catalyst showed excellent stability in 100 h‐lifetime test at high space velocity owing to the confinement of the ordered mesoporous structure as well as the modification of catalyst structure by TMB.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v5.16
    DOI: 10.1002/slct.202000765
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2844262-3
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  • 6
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    Online Resource
    Engineering the Defects and Microstructures in Ferroelectrics for Enhanced/Novel Properties: An Emerging Way to Cope with Energy Crisis and Environmental Pollution
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 13 ( 2022-05)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 13 ( 2022-05)
    Abstract: In the past century, ferroelectrics are well known in electroceramics and microelectronics for their unique ferroelectric, piezoelectric, pyroelectric, and photovoltaic effects. Nowadays, the advances in understanding and tuning of these properties have greatly promoted a broader application potential especially in energy and environmental fields, by harvesting solar, mechanical, and heat energies. For example, high piezoelectricity and high pyroelectricity can be designed by defect or microstructure engineering for piezo‐ and pyro‐catalyst, respectively. Moreover, highly piezoelectric and broadband (UV–Vis–NIR) light‐responsive ferroelectrics can be designed via defect engineering, giving rise to a new concept of photoferroelectrics for efficient photocatalysis, piezocatalysis, pyrocatalysis, and related cocatalysis. This article first summarizes the recent developments in ferroelectrics in terms of piezoelectricity, pyroelectricity, and photovoltaic effects based on defect and microstructure engineering. Then, the potential applications in energy generation (i.e., photovoltaic effect, H 2 generation, and self‐powered multisource energy harvesting and signal sensing) and environmental protection (i.e., photo‐piezo‐pyro‐ cocatalytic dye degradation and CO 2 reduction) are reviewed. Finally, the outlook and challenges are discussed. This article not only covers an overview of the state‐of‐art advances of ferroelectrics, but also prospects their applications in coping with energy crisis and environmental pollution.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.13
    DOI: 10.1002/advs.202105368
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 7
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    Online Resource
    Hydrogels with Reversible Heat‐Trained Toughness for Convenient Manufacture
    Wiley ; 2023
    In:  Advanced Materials Technologies Vol. 8, No. 5 ( 2023-03)
    Details
    In: Advanced Materials Technologies, Wiley, Vol. 8, No. 5 ( 2023-03)
    Abstract: Manufacturing hydrogels with programmable and reversible mechanical performance is pivotal for practical applications. In this work, a simple yet effective strategy is developed to fulfill this goal by training hydrogels with heat in different environments. The key point is to delicately tune the formation of the crystalline domains, thus reversibly switching the materials from liquid to solid, or from soft to rigid. For illustration, hydrogel precursors are taken with soluble semicrystalline polyvinyl alcohol and noncrystalline hydrophilic polymers. Upon training with heat in the air and reswelling in aqueous media, super stable and tough hydrogels are readily afforded with the crystalline domains serving as load‐bearing phases and physical crosslinks, which endows the gels with satisfactory processability. Various factors, such as training temperature and duration, can effectively regulate the training effect and endows the hydrogels with highly programmable mechanical performance. Upon experiencing another training process with heat in the water, the crystalline domains can be readily disrupted, which endows the materials with good recyclability. Combining these advantages, this strategy is well adaptable for various processing technologies for manufacturing hydrogels, and enables the gels with promising applications such as antifouling hydrogel coatings.
    Type of Medium: Online Resource
    ISSN: 2365-709X , 2365-709X
    URL: Issue
    URL: Article
    DOI: 10.1002/admt.v8.5
    DOI: 10.1002/admt.202201346
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2850995-X
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  • 8
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    Tethered Small‐Molecule Acceptors Simultaneously Enhance the Efficiency and Stability of Polymer Solar Cells
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 2 ( 2023-01)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 2 ( 2023-01)
    Abstract: For polymer solar cells (PSCs), the mixture of polymer donors and small‐molecule acceptors (SMAs) is fine‐tuned to realize a favorable kinetically trapped morphology and thus a commercially viable device efficiency. However, the thermodynamic relaxation of the mixed domains within the blend raises concerns related to the long‐term operational stability of the devices, especially in the record‐holding Y‐series SMAs. Here, a new class of dimeric Y6‐based SMAs tethered with differential flexible spacers is reported to regulate their aggregation and relaxation behavior. In their polymer blends with PM6, it is found that they favor an improved structural order relative to that of Y6 counterpart. Most importantly, the tethered SMAs show large glass transition temperatures to suppress the thermodynamic relaxation in mixed domains. For the high‐performing dimeric blend, an unprecedented open circuit voltage of 0.87 V is realized with a conversion efficiency of 17.85%, while those of regular Y6‐base devices only reach 0.84 V and 16.93%, respectively. Most importantly, the dimer‐based device possesses substantially reduced burn‐in efficiency loss, retaining more than 80% of the initial efficiency after operating at the maximum power point under continuous illumination for 700 h. The tethering approach provides a new direction to develop PSCs with high efficiency and excellent operating stability.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.2
    DOI: 10.1002/adma.202206563
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 9
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    Online Resource
    Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30
    Wiley ; 2016
    In:  Cancer Science Vol. 107, No. 4 ( 2016-04), p. 507-513
    Details
    In: Cancer Science, Wiley, Vol. 107, No. 4 ( 2016-04), p. 507-513
    Abstract: We previously found that a low dose of sorafenib had a prometastatic effect on hepatocellular carcinoma (HCC), which was caused by downregulation of TIP30 expression. More recently, metformin has been shown to have potential as a preventive and therapeutic agent for different cancers, including HCC. This study evaluated whether the combination of sorafenib and metformin is sufficient to revert the expression of TIP30, thereby simultaneously reducing lung metastasis and improving survival. Our data show that the combination of sorafenib and metformin inhibits proliferation and invasion in vitro , prolongs median survival, and reduces lung metastasis of HCC in vivo . This effect is closely associated with the upregulation of TIP30, partly through activating AMP‐activated protein kinase. Thioredoxin, a prometastasis factor, is negatively regulated by TIP30 and plays an essential role during the process of HCC metastasis. Overall, our results suggest that metformin might be a potent enhancer for the treatment of HCC by using sorafenib.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.2016.107.issue-4
    DOI: 10.1111/cas.12885
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 10
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    ZnO‐Doped In 2 O 3 Front Transparent Contact Enables 〉24.0% Silicon Heterojunction Solar Cells
    Wiley ; 2023
    In:  Energy Technology Vol. 11, No. 4 ( 2023-04)
    Details
    In: Energy Technology, Wiley, Vol. 11, No. 4 ( 2023-04)
    Abstract: Transparent conductive oxide (TCO) film acts as the window layer and carrier transport layer of silicon heterojunction (SHJ) solar cells. The optoelectrical and contact properties of TCO films, as well as the sputtering damage, limit the further efficiency improvement. Herein, the microstructure, morphology, and optoelectrical properties of sputtering‐prepared zinc‐doped indium oxide (IZO) are analyzed. The substrate temperature has a significant impact on the film growth and the cell performance. The IZO film is amorphous when substrate temperature is below 200 °C, while it seems the emergence of nanocrystals with the increased temperature, resulting in the highest conductivity (3070 S cm −1 ) and carrier mobility (47.9 cm 2  V −1  s −1 ). In addition, the low carrier concentration and surface potential of IZO promote less optical parasitic absorption and higher work function. The IZO films are applied as the contact layer of SHJ solar cells. An impressive efficiency of 24.02% on an M2‐sized wafer is achieved, indicating great potential for the mass production application after careful optimization.
    Type of Medium: Online Resource
    ISSN: 2194-4288 , 2194-4296
    URL: Issue
    URL: Article
    DOI: 10.1002/ente.v11.4
    DOI: 10.1002/ente.202201310
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2700412-0
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