In:
The Journal of Immunology, The American Association of Immunologists, Vol. 194, No. 1_Supplement ( 2015-05-01), p. 205.13-205.13
Abstract:
Intestinal epithelial cells which are exposed to microbes tightly restrict the influx of luminal antigens. They also contribute to establish the tolerogenic immune microenvironment through the induction of retinoic acid, TGF-β, and IL-25 production. However, intestinal contents are continuously introduced into Peyer’s patches through M cells which are specialized epithelial cells to take up the luminal antigens. Consequently, Peyer’s patches constitute specialized immune microenvironment. Although the mechanism for luminal antigen uptake into M cells is not clearly defined, many studies suggest the role of apical proteins of M cells as a mediator for antigen influx. Here, we report the expression of C5aR, TLR 1/2, ATP-gated P2X7 receptor (P2X7R), and formyl peptide receptor 2 (FPR-2) on apical area of M cells. In addition, we found that receptor itself and/or crosstalk among these receptors were able to regulate not only modulation of the Peyer’s patch microenvironment but also transcytosis of luminal antigens. Especially, when LL-37, one of ligands for P2X7R and FPR-2, was applied to oral mucosal vaccine model, it promoted the induction of antigen-specific immune response through M cell antigen-targeting and modulation of Peyer’s patch microenvironment. Collectively, we conclude that interaction between luminal antigens and apical receptors on M cells initiate the signaling for immune induction and that these receptors could be used as new targets for oral vaccine delivery.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.194.Supp.205.13
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2015
detail.hit.zdb_id:
1475085-5
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